SCI和EI收录∣中国化工学会会刊

中国化学工程学报 ›› 2021, Vol. 38 ›› Issue (10): 286-293.DOI: 10.1016/j.cjche.2021.05.021

• Materials and Product Engineering • 上一篇    

Rational design and synthesis of upconversion luminescence-based optomagnetic multifunctional nanorattles for drug delivery

Xuhua Liang1,2, Yanyan Zhao1,2, Min Cheng1,2, Fei Zhang3   

  1. 1. College of Biology Pharmacy and Food Engineering, Shangluo University, Shangluo 726000, China;
    2. Shaanxi Qinling Industrial Technology Research Institute of Special Biological Resources, Shangluo 726000, China;
    3. Shaanxi Tasly Plants Pharmaceutical Co., Ltd, Shangluo 726000, China
  • 收稿日期:2021-02-03 修回日期:2021-05-08 出版日期:2021-10-28 发布日期:2021-12-02
  • 通讯作者: Xuhua Liang
  • 基金资助:
    This work was supported by the Key Research and Development Plan of Shaanxi Province (2020GY-313), the Specialized Research Fund of Education Department of Shaanxi Province (19JK0255), the Specialized Scientific Research Fund Projects of Academician Shengyong Zhang (18YSZX001), and the Science and Technology Innovation Team of Shangluo University (20SCX02).

Rational design and synthesis of upconversion luminescence-based optomagnetic multifunctional nanorattles for drug delivery

Xuhua Liang1,2, Yanyan Zhao1,2, Min Cheng1,2, Fei Zhang3   

  1. 1. College of Biology Pharmacy and Food Engineering, Shangluo University, Shangluo 726000, China;
    2. Shaanxi Qinling Industrial Technology Research Institute of Special Biological Resources, Shangluo 726000, China;
    3. Shaanxi Tasly Plants Pharmaceutical Co., Ltd, Shangluo 726000, China
  • Received:2021-02-03 Revised:2021-05-08 Online:2021-10-28 Published:2021-12-02
  • Contact: Xuhua Liang
  • Supported by:
    This work was supported by the Key Research and Development Plan of Shaanxi Province (2020GY-313), the Specialized Research Fund of Education Department of Shaanxi Province (19JK0255), the Specialized Scientific Research Fund Projects of Academician Shengyong Zhang (18YSZX001), and the Science and Technology Innovation Team of Shangluo University (20SCX02).

摘要: Optomagnetic multifunctional composite based on upconversion luminescence nanomaterial is regarded as a promising strategy for bioimaging, disease diagnosis and targeted delivery of drugs. To explore a mesoporous nanostructure with excellent water dispersibility and high drug-loading capacity, a novel nanorattle-structured Fe3O4@SiO2@NaYF4:Yb,Er magnetic upconversion nanorattle (MUCNR) was successfully designed by using Fe3O4 as core and NaYF4:Yb,Er nanocrystals as shell. The microstructures and crystal phase of the as-prepared MUCNRs were evaluated by transmission electron microscopy, X-ray powder diffraction and N2 adsorption/desorption isotherms. The Kirkendall effect was adapted to explain the formation mechanism of the MUCNRs. The loading content and encapsulation efficiency of doxorubicin hydrochloride (DOX) could reach as high as 18.2% and 60.7%, respectively. Moreover, the DOX loading MUCNR (DOX-MUCNR) system showed excellent sustained drug release and strong pH-dependent performance, which was conducive to drug release at the slightly acidic microenvironment of tumor. Microcalorimetry was used to quantify the interactions between the carrier structure and drug release rate directly. The heat release rates in the heat-flow diagrams are basically consistent with the DOX release rate, thereby showing that microcalorimetry assay not only provides a unique thermodynamic explanation for the structure-activity relationship of Fe3O4@SiO2@NaYF4:Yb,Er MUCNRs but also provides powerful guidance to avoid the blind selection or design of drug carriers. Therefore, our work firmly provided a comprehensive perspective for using Fe3O4@SiO2@NaYF4:Yb,Er MUCNRs as a remarkable magnetic targeted drug carrier.

关键词: Optomagnetic nanocomposite, Nanorattle, Upconversion luminescence, Iron oxide, Drug delivery

Abstract: Optomagnetic multifunctional composite based on upconversion luminescence nanomaterial is regarded as a promising strategy for bioimaging, disease diagnosis and targeted delivery of drugs. To explore a mesoporous nanostructure with excellent water dispersibility and high drug-loading capacity, a novel nanorattle-structured Fe3O4@SiO2@NaYF4:Yb,Er magnetic upconversion nanorattle (MUCNR) was successfully designed by using Fe3O4 as core and NaYF4:Yb,Er nanocrystals as shell. The microstructures and crystal phase of the as-prepared MUCNRs were evaluated by transmission electron microscopy, X-ray powder diffraction and N2 adsorption/desorption isotherms. The Kirkendall effect was adapted to explain the formation mechanism of the MUCNRs. The loading content and encapsulation efficiency of doxorubicin hydrochloride (DOX) could reach as high as 18.2% and 60.7%, respectively. Moreover, the DOX loading MUCNR (DOX-MUCNR) system showed excellent sustained drug release and strong pH-dependent performance, which was conducive to drug release at the slightly acidic microenvironment of tumor. Microcalorimetry was used to quantify the interactions between the carrier structure and drug release rate directly. The heat release rates in the heat-flow diagrams are basically consistent with the DOX release rate, thereby showing that microcalorimetry assay not only provides a unique thermodynamic explanation for the structure-activity relationship of Fe3O4@SiO2@NaYF4:Yb,Er MUCNRs but also provides powerful guidance to avoid the blind selection or design of drug carriers. Therefore, our work firmly provided a comprehensive perspective for using Fe3O4@SiO2@NaYF4:Yb,Er MUCNRs as a remarkable magnetic targeted drug carrier.

Key words: Optomagnetic nanocomposite, Nanorattle, Upconversion luminescence, Iron oxide, Drug delivery