SCI和EI收录∣中国化工学会会刊

Chin.J.Chem.Eng. ›› 2016, Vol. 24 ›› Issue (4): 513-520.DOI: 10.1016/j.cjche.2016.01.003

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Production of succinic acid in basket and mobile bed bioreactors-Comparative analysis of substrate mass transfer aspects

Anca-Irina Galaction1, Dan Cascaval2, Ramona-MihaelaMatran2, Alexandra Tucaliuc2   

  1. 1 "Grigore T. Popa" University of Medicine and Pharmacy of Iasi, Faculty of Medical Bioengineering, Dept. of Biomedical Science, M. Kogalniceanu 9-13, 700454 Iasi, Romania;
    2 "Gheorghe Asachi" Technical University of Iasi, Faculty of Chemical Engineering and Environmental Protection, Dept. of Biochemical Engineering, D. Mangeron 73, 700050 Iasi, Romania
  • Received:2015-02-03 Revised:2015-05-11 Online:2016-05-27 Published:2016-04-28
  • Contact: Dan Cascaval
  • Supported by:

    Supported by the Grant PN-II-PT-PCCA-2011-3.1-1268 authorized by The National Council for Scientific Research-Executive Unit for Financing Higher Education, Research, Development and Innovation (CNCS-UEFISCDI).

Production of succinic acid in basket and mobile bed bioreactors-Comparative analysis of substrate mass transfer aspects

Anca-Irina Galaction1, Dan Cascaval2, Ramona-MihaelaMatran2, Alexandra Tucaliuc2   

  1. 1 "Grigore T. Popa" University of Medicine and Pharmacy of Iasi, Faculty of Medical Bioengineering, Dept. of Biomedical Science, M. Kogalniceanu 9-13, 700454 Iasi, Romania;
    2 "Gheorghe Asachi" Technical University of Iasi, Faculty of Chemical Engineering and Environmental Protection, Dept. of Biochemical Engineering, D. Mangeron 73, 700050 Iasi, Romania
  • 通讯作者: Dan Cascaval
  • 基金资助:

    Supported by the Grant PN-II-PT-PCCA-2011-3.1-1268 authorized by The National Council for Scientific Research-Executive Unit for Financing Higher Education, Research, Development and Innovation (CNCS-UEFISCDI).

Abstract: The glucose mass transfer in the biosynthesis of succinic acid with immobilized Actinobacillus succinogenes cells has been comparatively analyzed for a bioreactor with mobile bed vs. a stationary basket bioreactor. The process has been considered to occur under substrate and product inhibitory effects. The results indicated that the bioreactor withmobile bed is more efficient for biocatalyst particles with a diameter over 3mm,while the basket bioreactor ismore efficient for smaller biocatalyst particles and basket bed thickness below 5mm. The performances of both configurations of immobilized A. succinogenes cell beds were found to be superior to the column packed bed bioreactor.

Key words: Mass transfer, Diffusion, Stirred vessel, Immobilized cells, Basket bioreactor, Succinic acid

摘要: The glucose mass transfer in the biosynthesis of succinic acid with immobilized Actinobacillus succinogenes cells has been comparatively analyzed for a bioreactor with mobile bed vs. a stationary basket bioreactor. The process has been considered to occur under substrate and product inhibitory effects. The results indicated that the bioreactor withmobile bed is more efficient for biocatalyst particles with a diameter over 3mm,while the basket bioreactor ismore efficient for smaller biocatalyst particles and basket bed thickness below 5mm. The performances of both configurations of immobilized A. succinogenes cell beds were found to be superior to the column packed bed bioreactor.

关键词: Mass transfer, Diffusion, Stirred vessel, Immobilized cells, Basket bioreactor, Succinic acid