%0 Journal Article %A Marzia Rahman %A Md. Anamul Hoque %A Malik Abdul Rub %A Mohammed Abdullah Khan %T Interaction of cetyltrimethylammonium bromide with cefixime trihydrate drug at different temperatures and compositions: Effect of different electrolytes %D 2019 %R 10.1016/j.cjche.2018.10.022 %J Chinese Journal of Chemical Engineering %P 1895-1903 %V 27 %N 8 %X Herein, conductivity measurements have been carried out to explore the interaction between cetyltrimethylammonium bromide (CTAB, a cationic surfactant) and antibiotic drug (cefixime trihydrate (CMT)) in water and also in occurrence of inorganic salts (NaCl, Na2SO4 and Na3PO4) over the temperature range of 303.15-323.15 K with an interval of 5 K. In all cases, two critical micelle concentrations (c*) were achieved for the CMT-surfactant system. Addition of CMT drug to CTAB solution decreases the values of c* which indicates the interaction between CMT and CTAB. Both values of c* for CMT-CTAB mixture in the presence of salts are lower in magnitude compared to the aqueous medium which indicates that micellization of the CMT-CTAB mixed system is favorable in salt solution. The values of △Gm0 were obtained to be negative indicating the spontaneity of the micellization process and the extent of spontaneity further increases by means of rising temperature. The obtained outcomes from the △Hm0 and △Sm0 values disclose that the interactions between CMT and CTAB are mostly electrostatic along with hydrophobic in nature. The thermodynamic parameters of transfer and enthalpy-entropy compensation phenomenon were also determined and discussed in detail. %U https://cjche.cip.com.cn/EN/10.1016/j.cjche.2018.10.022