Simulation and analysis of multi-stage centrifugal fractional extraction process of 4-nitrobenzene glycine enantiomers

doi:10.1016/j.cjche.2015.08.015

Chin.J.Chem.Eng. ›› 2015, Vol. 23 ›› Issue (11): 1774-1781.DOI: 10.1016/j.cjche.2015.08.015

• SEPARATION SCIENCE AND ENGINEERING • Previous Articles Next Articles

Simulation and analysis of multi-stage centrifugal fractional extraction process of 4-nitrobenzene glycine enantiomers

Ping Wen¹, Kewen Tang², Jicheng Zhou¹, Panliang Zhang²

1 Department of Chemical Engineering, Xiang Tan University, Xiangtan 411105, China;
2 Department of Chemistry and Chemical Engineering, Hunan Institute of Science and Technology, Yueyang 414006, China

Received:2014-01-15 Revised:2014-06-17 Online:2015-12-18 Published:2015-11-28
Contact: Jicheng Zhou, Panliang Zhang
Supported by:
Supported by the National Natural Science Foundation of China (21176062), the Natural Science Foundation of Hunan Province (12JJ2007), Scientific Research Fund of Hunan Provincial Education Department (12B053), Science and Technology Planning Project of Hunan Province (2012GK3107) and Aid Program for Science and Technology Innovative Research Team in Higher Educational Institutions of Hunan Province.

Simulation and analysis of multi-stage centrifugal fractional extraction process of 4-nitrobenzene glycine enantiomers

Ping Wen¹, Kewen Tang², Jicheng Zhou¹, Panliang Zhang²

1 Department of Chemical Engineering, Xiang Tan University, Xiangtan 411105, China;
2 Department of Chemistry and Chemical Engineering, Hunan Institute of Science and Technology, Yueyang 414006, China

通讯作者: Jicheng Zhou, Panliang Zhang
基金资助:
Supported by the National Natural Science Foundation of China (21176062), the Natural Science Foundation of Hunan Province (12JJ2007), Scientific Research Fund of Hunan Provincial Education Department (12B053), Science and Technology Planning Project of Hunan Province (2012GK3107) and Aid Program for Science and Technology Innovative Research Team in Higher Educational Institutions of Hunan Province.

Abstract

Abstract: Based on the interfacial ligand exchangemodel and the law of conservation ofmass, themulti-stage enantioselective liquid-liquid extraction model has been established to analyze and discuss on multi-stage centrifugal fractional extraction process of 4-nitrobenzene glycine (PGL) enantiomers. The influence of phase ratio, extractant concentration, and PF₆^- concentration on the concentrations of enantiomers in the extract and raffinate was investigated by experiment and simulation. A good agreement between model and experiment was obtained. On this basis, the influence ofmany parameters such as location of stage, concentration levels, extractant excess, and number of stages on the symmetric separation performance was simulated. The optimal location of feed stage is the middle of fractional extraction equipment. The feed flow must satisfy a restricted relationship on flow ratios and the liquid throughout of centrifugal device. For desired purity specification, the required flow ratios decrease with extractant concentration and increase with PF₆^- concentration.When the number of stages is 18 stages at extractant excess of 1.0 or 14 stages at extractant excess of 2.0, the eeeq (equal enantiomeric excess) can reach to 99%.

Key words: Fractional extraction, Multistage model, Interfacial ligand exchange, Chiral separation

摘要： Based on the interfacial ligand exchangemodel and the law of conservation ofmass, themulti-stage enantioselective liquid-liquid extraction model has been established to analyze and discuss on multi-stage centrifugal fractional extraction process of 4-nitrobenzene glycine (PGL) enantiomers. The influence of phase ratio, extractant concentration, and PF₆^- concentration on the concentrations of enantiomers in the extract and raffinate was investigated by experiment and simulation. A good agreement between model and experiment was obtained. On this basis, the influence ofmany parameters such as location of stage, concentration levels, extractant excess, and number of stages on the symmetric separation performance was simulated. The optimal location of feed stage is the middle of fractional extraction equipment. The feed flow must satisfy a restricted relationship on flow ratios and the liquid throughout of centrifugal device. For desired purity specification, the required flow ratios decrease with extractant concentration and increase with PF₆^- concentration.When the number of stages is 18 stages at extractant excess of 1.0 or 14 stages at extractant excess of 2.0, the eeeq (equal enantiomeric excess) can reach to 99%.

关键词: Fractional extraction, Multistage model, Interfacial ligand exchange, Chiral separation

Ping Wen, Kewen Tang, Jicheng Zhou, Panliang Zhang. Simulation and analysis of multi-stage centrifugal fractional extraction process of 4-nitrobenzene glycine enantiomers[J]. Chin.J.Chem.Eng., 2015, 23(11): 1774-1781.

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Simulation and analysis of multi-stage centrifugal fractional extraction process of 4-nitrobenzene glycine enantiomers

Simulation and analysis of multi-stage centrifugal fractional extraction process of 4-nitrobenzene glycine enantiomers

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