Effect of carboxymethyl cellulose on dissolution kinetics of carboxymethyl cellulose-sodium carbonate two-component tablet

doi:10.1016/j.cjche.2017.01.013

Abstract

Abstract: Sodium carbonate and carboxymethyl cellulose powders are compressed into two-component tablets with three mass ratios, 97%:3%, 95%:5% and 93%:7%. The dissolution tests for two-component tablets and reference pure sodium carbonate tablets are carried out at various temperatures. The dissolution process of each tablet is measured by electrical conductivity tracking method and the concentration of dissolved sodium carbonate is quantified with calibrated conductivity-concentration converting equation of sodium carbonate. The quantified dissolution data is fitted with both surface reaction model and diffusion layer model and the results clearly show that surface reaction model is suggested as the appropriate dissolution model for all measured tablets. Therefore, it is determined that carboxymethyl cellulose is a stable element to remain the dissolution mechanism of tablet unchanged. The dissolution rate constant quantified with surface reaction model presents that carboxymethyl cellulose-sodium carbonate two-component tablets obtain significant higher dissolution rate constant than pure sodium carbonate tablet and higher proportion of carboxymethyl cellulose leads to apparent higher dissolution rate constant. The results prove for the usage of carboxymethyl cellulose in most practical applications at a relative low-level, the effect of carboxymethyl cellulose is effective and positive for two-component tablet to enhance the dissolution process and improve dissolution rate constant and this effect is speculated coming from its dynamic physical transforming process in water including dilation and conglutination.

Key words: Carboxymethyl cellulose, Sodium carbonate, Electrical conductivity, Temperature, Surface reaction model, Dissolution rate constant

摘要： Sodium carbonate and carboxymethyl cellulose powders are compressed into two-component tablets with three mass ratios, 97%:3%, 95%:5% and 93%:7%. The dissolution tests for two-component tablets and reference pure sodium carbonate tablets are carried out at various temperatures. The dissolution process of each tablet is measured by electrical conductivity tracking method and the concentration of dissolved sodium carbonate is quantified with calibrated conductivity-concentration converting equation of sodium carbonate. The quantified dissolution data is fitted with both surface reaction model and diffusion layer model and the results clearly show that surface reaction model is suggested as the appropriate dissolution model for all measured tablets. Therefore, it is determined that carboxymethyl cellulose is a stable element to remain the dissolution mechanism of tablet unchanged. The dissolution rate constant quantified with surface reaction model presents that carboxymethyl cellulose-sodium carbonate two-component tablets obtain significant higher dissolution rate constant than pure sodium carbonate tablet and higher proportion of carboxymethyl cellulose leads to apparent higher dissolution rate constant. The results prove for the usage of carboxymethyl cellulose in most practical applications at a relative low-level, the effect of carboxymethyl cellulose is effective and positive for two-component tablet to enhance the dissolution process and improve dissolution rate constant and this effect is speculated coming from its dynamic physical transforming process in water including dilation and conglutination.

关键词: Carboxymethyl cellulose, Sodium carbonate, Electrical conductivity, Temperature, Surface reaction model, Dissolution rate constant

Changdong Li, Carlos Amador, Yulong Ding. Effect of carboxymethyl cellulose on dissolution kinetics of carboxymethyl cellulose-sodium carbonate two-component tablet[J]. , 2017, 25(10): 1545-1550.

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