Interaction of antipsychotic drug with novel surfactants: Micellization and binding studies

doi:10.1016/j.cjche.2017.09.009

Abstract

Abstract: The interaction of cationic gemini surfactants (alkanediyl-α,ω-bis(alkyl dimethylammonium bromide)) with an antipsychotic drug (chlorpromazine hydrochloride (CPZ)) has been investigated. Various micellar and interfacial parameters have been deliberated by surface tension measurement to report the nature of interactions between drug and novel surfactant mixtures. The behavior of mixed systems, their compositions and activities of components have been analyzed in the light of Rubingh's theory. The results indicate synergism in the binary mixtures. The binding study between CPZ and surfactants has been done by spectroscopic techniques such as UV-visible and fluorescence. The results are discussed in the light of the use of gemini surfactants as promising drug delivery agents for phenothiazine drugs, and hence, improve their bioavailability.

Key words: Gemini surfactants, Antipsychotic drug, Chlorpromazine hydrochloride, Mixed micellization

摘要： The interaction of cationic gemini surfactants (alkanediyl-α,ω-bis(alkyl dimethylammonium bromide)) with an antipsychotic drug (chlorpromazine hydrochloride (CPZ)) has been investigated. Various micellar and interfacial parameters have been deliberated by surface tension measurement to report the nature of interactions between drug and novel surfactant mixtures. The behavior of mixed systems, their compositions and activities of components have been analyzed in the light of Rubingh's theory. The results indicate synergism in the binary mixtures. The binding study between CPZ and surfactants has been done by spectroscopic techniques such as UV-visible and fluorescence. The results are discussed in the light of the use of gemini surfactants as promising drug delivery agents for phenothiazine drugs, and hence, improve their bioavailability.

关键词: Gemini surfactants, Antipsychotic drug, Chlorpromazine hydrochloride, Mixed micellization

Naved Azum, Malik Abdul Rub, Abdullah M. Asiri. Interaction of antipsychotic drug with novel surfactants: Micellization and binding studies[J]. Chin.J.Chem.Eng., 2018, 26(3): 566-573.

Naved Azum, Malik Abdul Rub, Abdullah M. Asiri. Interaction of antipsychotic drug with novel surfactants: Micellization and binding studies[J]. Chinese Journal of Chemical Engineering, 2018, 26(3): 566-573.

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