Hollow mesoporous polyaniline nanoparticles with high drug payload and robust photothermal capability for cancer combination therapy

doi:10.1016/j.cjche.2021.03.011

Chinese Journal of Chemical Engineering ›› 2021, Vol. 38 ›› Issue (10): 221-228.DOI: 10.1016/j.cjche.2021.03.011

• Biotechnology and Bioengineering • Previous Articles Next Articles

Hollow mesoporous polyaniline nanoparticles with high drug payload and robust photothermal capability for cancer combination therapy

Yinfeng Zhang¹, Fang Fang², Yongjie Chen³, Min Li², Li Li¹, Wenyue Li⁴, Jinfeng Zhang²

1. International Medical Center, Beijing Friendship Hospital, Capital Medical University, Beijing, 100050, China;
2. Key Laboratory of Molecular Medicine and Biotherapy, School of Life Sciences, Beijing Institute of Technology, Beijing 100081, China;
3. College of Pharmacy, Chongqing Medical University, Chongqing 400016, China;
4. School of Electrical, Computer and Energy Engineering, Arizona State University, Tempe, Arizona, USA

Received:2020-12-23 Revised:2021-03-19 Online:2021-12-02 Published:2021-10-28
Contact: Wenyue Li, Jinfeng Zhang
Supported by:
We would like to acknowledge financial support by the National Natural Science Foundation of China (32001010 and 21701018), Beijing Natural Science Foundation (2214078), Beijing Institute of Technology Research Fund Program for Young Scholars, and The Young Elite Scientist Sponsorship Program of Beijing Association for Science and Technology (2021-2023). J. Zhang would also like to thank Biological & Medical Engineering Core Facilities (Beijing Institute of Technology) for providing advanced equipment.

Hollow mesoporous polyaniline nanoparticles with high drug payload and robust photothermal capability for cancer combination therapy

Yinfeng Zhang¹, Fang Fang², Yongjie Chen³, Min Li², Li Li¹, Wenyue Li⁴, Jinfeng Zhang²

1. International Medical Center, Beijing Friendship Hospital, Capital Medical University, Beijing, 100050, China;
2. Key Laboratory of Molecular Medicine and Biotherapy, School of Life Sciences, Beijing Institute of Technology, Beijing 100081, China;
3. College of Pharmacy, Chongqing Medical University, Chongqing 400016, China;
4. School of Electrical, Computer and Energy Engineering, Arizona State University, Tempe, Arizona, USA

通讯作者: Wenyue Li, Jinfeng Zhang
基金资助:
We would like to acknowledge financial support by the National Natural Science Foundation of China (32001010 and 21701018), Beijing Natural Science Foundation (2214078), Beijing Institute of Technology Research Fund Program for Young Scholars, and The Young Elite Scientist Sponsorship Program of Beijing Association for Science and Technology (2021-2023). J. Zhang would also like to thank Biological & Medical Engineering Core Facilities (Beijing Institute of Technology) for providing advanced equipment.

Abstract

Abstract: In recent years, synergistic chemo-photothermal therapy has revealed promising potential in treatments against various kinds of cancer. However, the development of superb photothermal agents with high drug loading capacity is still highly required. In this work, a hollow mesoporous polyaniline nanoparticle (HPANI NP) has been developed for encapsulating chemotherapeutic drug doxorubicin (DOX) with an remarkable drug loading content as high as 37.5%. Additional PEG modification endowed the drug-loaded HPANI NPs with improved water-dispersibility and bioavailability. Such PEG-HPANI-DOX NPs exhibited strong NIR absorbance and robust photothermal conversion capacity, exhibiting highly efficient synergistic cancer treatment. More interestingly, the responsively released DOX molecules could emit strong red fluorescence, which could be employed to monitor the cellular endocytosis and drug release profile of PEG-HPANI-DOX NPs. Finally, the as-fabricated NPs showed good biocompatibility and low toxicity, serving as a promising nanoagent for highly efficient drug delivery and cancer combination therapy.

Key words: Hollow mesoporous polyaniline nanoparticles, Drug delivery, Nanocarriers, Chemo-photothermal therapy, Cancer combination therapy

摘要： In recent years, synergistic chemo-photothermal therapy has revealed promising potential in treatments against various kinds of cancer. However, the development of superb photothermal agents with high drug loading capacity is still highly required. In this work, a hollow mesoporous polyaniline nanoparticle (HPANI NP) has been developed for encapsulating chemotherapeutic drug doxorubicin (DOX) with an remarkable drug loading content as high as 37.5%. Additional PEG modification endowed the drug-loaded HPANI NPs with improved water-dispersibility and bioavailability. Such PEG-HPANI-DOX NPs exhibited strong NIR absorbance and robust photothermal conversion capacity, exhibiting highly efficient synergistic cancer treatment. More interestingly, the responsively released DOX molecules could emit strong red fluorescence, which could be employed to monitor the cellular endocytosis and drug release profile of PEG-HPANI-DOX NPs. Finally, the as-fabricated NPs showed good biocompatibility and low toxicity, serving as a promising nanoagent for highly efficient drug delivery and cancer combination therapy.

关键词: Hollow mesoporous polyaniline nanoparticles, Drug delivery, Nanocarriers, Chemo-photothermal therapy, Cancer combination therapy

Yinfeng Zhang, Fang Fang, Yongjie Chen, Min Li, Li Li, Wenyue Li, Jinfeng Zhang. Hollow mesoporous polyaniline nanoparticles with high drug payload and robust photothermal capability for cancer combination therapy[J]. Chinese Journal of Chemical Engineering, 2021, 38(10): 221-228.

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Hollow mesoporous polyaniline nanoparticles with high drug payload and robust photothermal capability for cancer combination therapy

Hollow mesoporous polyaniline nanoparticles with high drug payload and robust photothermal capability for cancer combination therapy

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