SCI和EI收录∣中国化工学会会刊

Chinese Journal of Chemical Engineering ›› 2022, Vol. 41 ›› Issue (1): 6-21.DOI: 10.1016/j.cjche.2021.08.017

• Review • Previous Articles     Next Articles

Green biomanufacturing promoted by automatic retrobiosynthesis planning and computational enzyme design

Ziheng Cui, Shiding Zhang, Shengyu Zhang, Biqiang Chen, Yushan Zhu, Tianwei Tan   

  1. National Energy R&D Center for Biorefinery, College of Life Science and Technology, Beijing University of Chemical Technology, Beijing 100029, China
  • Received:2021-07-06 Revised:2021-08-15 Online:2022-02-25 Published:2022-01-28
  • Contact: Yushan Zhu,E-mail address:zhuys@mail.buct.edu.cn;Tianwei Tan,E-mail address:twtan@mail.buct.edu.cn
  • Supported by:
    We gratefully acknowledge the support from the National Natural Science Foundation of China (U1663227, 21861132017, 21811530003, 21878170).

Green biomanufacturing promoted by automatic retrobiosynthesis planning and computational enzyme design

Ziheng Cui, Shiding Zhang, Shengyu Zhang, Biqiang Chen, Yushan Zhu, Tianwei Tan   

  1. National Energy R&D Center for Biorefinery, College of Life Science and Technology, Beijing University of Chemical Technology, Beijing 100029, China
  • 通讯作者: Yushan Zhu,E-mail address:zhuys@mail.buct.edu.cn;Tianwei Tan,E-mail address:twtan@mail.buct.edu.cn
  • 基金资助:
    We gratefully acknowledge the support from the National Natural Science Foundation of China (U1663227, 21861132017, 21811530003, 21878170).

Abstract: Biomanufacturing, which uses renewable resources as raw materials and uses biological processes to produce energy and chemicals, has long been regarded as a production model that replaces the unsustainable fossil economy. The construction of non-natural and efficient biosynthesis routes of chemicals is an important goal of green biomanufacturing. Traditional methods that rely on experience are difficult to support the realization of this goal. However, with the rapid development of information technology, the intelligence of biomanufacturing has brought hope to achieve this goal. Retrobiosynthesis and computational enzyme design, as two of the main technologies in intelligent biomanufacturing, have developed rapidly in recent years and have made great achievements and some representative works have demonstrated the great value that the integration of the two fields may bring. To achieve the final integration of the two fields, it is necessary to examine the information, methods and tools from a bird’s-eye view, and to find a feasible idea and solution for establishing a connection point. For this purpose, this article briefly reviewed the main ideas, methods and tools of the two fields, and put forward views on how to achieve the integration of the two fields.

Key words: Biomanufacturing, Retrobiosynthesis, Computational enzyme design, Biobased chemicals

摘要: Biomanufacturing, which uses renewable resources as raw materials and uses biological processes to produce energy and chemicals, has long been regarded as a production model that replaces the unsustainable fossil economy. The construction of non-natural and efficient biosynthesis routes of chemicals is an important goal of green biomanufacturing. Traditional methods that rely on experience are difficult to support the realization of this goal. However, with the rapid development of information technology, the intelligence of biomanufacturing has brought hope to achieve this goal. Retrobiosynthesis and computational enzyme design, as two of the main technologies in intelligent biomanufacturing, have developed rapidly in recent years and have made great achievements and some representative works have demonstrated the great value that the integration of the two fields may bring. To achieve the final integration of the two fields, it is necessary to examine the information, methods and tools from a bird’s-eye view, and to find a feasible idea and solution for establishing a connection point. For this purpose, this article briefly reviewed the main ideas, methods and tools of the two fields, and put forward views on how to achieve the integration of the two fields.

关键词: Biomanufacturing, Retrobiosynthesis, Computational enzyme design, Biobased chemicals