Continuous synthesis of N, N-dicyanoethylaniline in microreactors: Reaction kinetics and process intensification

doi:10.1016/j.cjche.2024.06.001

Chinese Journal of Chemical Engineering ›› 2024, Vol. 72 ›› Issue (8): 95-105.DOI: 10.1016/j.cjche.2024.06.001

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Continuous synthesis of N, N-dicyanoethylaniline in microreactors: Reaction kinetics and process intensification

Pengcheng Lu¹, Yaoyao Li¹, Jianjun Zhang², Yuchao Zhao¹, Qingqiang Wang¹, Ying Chen¹, Nan Jin¹, Xiugang Yu³

1 Shandong Provincial Key Laboratory of Chemical Engineering and Process, College of Chemistry and Chemical Engineering, Yantai University, Yantai 264005, China;
2 Shandong ANOKY Chemical Technology Research Co., Ltd., Yantai 265601, China;
3 Yantai Guobang Chemical Machinery Technology Co., Ltd., Yantai 264000, China

Received:2024-02-23 Revised:2024-06-05 Online:2024-10-17 Published:2024-08-28
Contact: Yuchao Zhao,E-mail:yczhao@ytu.edu.cn;Nan Jin,E-mail:nanjin@ytu.edu.cn
Supported by:
We gratefully acknowledge the financial supports from National Natural Science Foundation of China (22378344, 22208278), Natural Science Foundation of Shandong Province (ZR2023MB120, ZR2023QB152) and Youth Innovation Team Plan of Shandong Province (2022KJ270).

Continuous synthesis of N, N-dicyanoethylaniline in microreactors: Reaction kinetics and process intensification

Pengcheng Lu¹, Yaoyao Li¹, Jianjun Zhang², Yuchao Zhao¹, Qingqiang Wang¹, Ying Chen¹, Nan Jin¹, Xiugang Yu³

1 Shandong Provincial Key Laboratory of Chemical Engineering and Process, College of Chemistry and Chemical Engineering, Yantai University, Yantai 264005, China;
2 Shandong ANOKY Chemical Technology Research Co., Ltd., Yantai 265601, China;
3 Yantai Guobang Chemical Machinery Technology Co., Ltd., Yantai 264000, China

通讯作者: Yuchao Zhao,E-mail:yczhao@ytu.edu.cn;Nan Jin,E-mail:nanjin@ytu.edu.cn
基金资助:
We gratefully acknowledge the financial supports from National Natural Science Foundation of China (22378344, 22208278), Natural Science Foundation of Shandong Province (ZR2023MB120, ZR2023QB152) and Youth Innovation Team Plan of Shandong Province (2022KJ270).

Abstract

Abstract: Cyanoethylation of phenylamine is one of the important steps for the production of dicyanoethyl-based disperse dyes. However, the exothermic nature of this reaction and the inherent instability of intermittent dynamic operation pose challenges in achieving both high safety and reaction efficiency. In this study, a continuous cyanoethylation of phenylamine for synthesizing N, N-dicyanoethylaniline in a microreactor system has been developed. By optimizing the reaction conditions, the reaction time was significantly reduced from over 2 h in batch operation to approximately 14 min in the microreactor, while high conversion and selectivity were maintained. Based on the reaction network constructed, the reaction kinetics was established, and the kinetic parameters were then determined. These findings provide valuable insights into a controllable cyanoethylation reaction, which would be helpful for the design of efficient processes and optimization of reactors.

Key words: Cyanoethylation, Microreactor, Kinetics, N, N-dicyanoethylaniline, Optimization, Safety

摘要： Cyanoethylation of phenylamine is one of the important steps for the production of dicyanoethyl-based disperse dyes. However, the exothermic nature of this reaction and the inherent instability of intermittent dynamic operation pose challenges in achieving both high safety and reaction efficiency. In this study, a continuous cyanoethylation of phenylamine for synthesizing N, N-dicyanoethylaniline in a microreactor system has been developed. By optimizing the reaction conditions, the reaction time was significantly reduced from over 2 h in batch operation to approximately 14 min in the microreactor, while high conversion and selectivity were maintained. Based on the reaction network constructed, the reaction kinetics was established, and the kinetic parameters were then determined. These findings provide valuable insights into a controllable cyanoethylation reaction, which would be helpful for the design of efficient processes and optimization of reactors.

关键词: Cyanoethylation, Microreactor, Kinetics, N, N-dicyanoethylaniline, Optimization, Safety

Pengcheng Lu, Yaoyao Li, Jianjun Zhang, Yuchao Zhao, Qingqiang Wang, Ying Chen, Nan Jin, Xiugang Yu. Continuous synthesis of N, N-dicyanoethylaniline in microreactors: Reaction kinetics and process intensification[J]. Chinese Journal of Chemical Engineering, 2024, 72(8): 95-105.

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Continuous synthesis of N, N-dicyanoethylaniline in microreactors: Reaction kinetics and process intensification

Continuous synthesis of N, N-dicyanoethylaniline in microreactors: Reaction kinetics and process intensification

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