Facile Preparation of Danazol Nanoparticles by High-Gravity Anti-solvent Precipitation(HGAP) Method

›› 2009, Vol. 17 ›› Issue (2): 318-323.

• PRODUCT ENGINEERING AND CHEMICAL TECHNOLOGY • Previous Articles Next Articles

Facile Preparation of Danazol Nanoparticles by High-Gravity Anti-solvent Precipitation(HGAP) Method

ZHAO Hong¹, WANG Jiexin¹, ZHANG Haixia¹, SHEN Zhigang^1,2, Jimmy Yun², CHEN Jianfeng¹

1. Sin-China Nano Technology Center, Key Lab for Nanomaterials, Ministry of Education, Beijing University of Chemical Technology, Beijing 10029, China;
2. Nanomaterials Technology Pte. Ltd., Singapore

Received:2008-09-03 Revised:2008-11-11 Online:2009-04-28 Published:2009-04-28
Supported by:
Supported by the National High Technology Research and Development Program of China (2006AA030202);the Talent Training Program of Beijing (2007B022)

Facile Preparation of Danazol Nanoparticles by High-Gravity Anti-solvent Precipitation(HGAP) Method

赵宏¹, 王洁欣¹, 张海霞¹, 沈志刚^1,2, 甄崇礼², 陈建峰¹

1. Sin-China Nano Technology Center, Key Lab for Nanomaterials, Ministry of Education, Beijing University of Chemical Technology, Beijing 10029, China;
2. Nanomaterials Technology Pte. Ltd., Singapore

通讯作者: CHEN Jianfeng,E-mail:chenjf@mail.buct.edu.cn
基金资助:
Supported by the National High Technology Research and Development Program of China (2006AA030202);the Talent Training Program of Beijing (2007B022)

Abstract

Abstract: The nanoparticles of the hydrophobic drug of danazol with narrow size distribution are facilely prepared by controlled high-gravity anti-solvent precipitation(HGAP) process.Intensified micromixing and uniform nucleation environment are created by the high-gravity equipment(rotating packed bed) in carrying out the anti-solvent precipitation process to produce nanoparticles.The average particle size decreases from 55 μm of the raw danazol to 190 nm of the nanoparticles.The Brunauer-Emmett-Teller(BET) surface area sharply increases from 0.66 m²·g^-1 to 15.08 m²·g^-1.Accordingly,the dissolution rate is greatly improved.The molecular state,chemical composition,and crystal form of the danazol nanoparticles remains unchanged after processing according to Fourier transform infrared(FTIR) and X-ray diffraction(XRD).The high recovery ratio and continuous production capacity are highly appreciated in industry.Therefore,the HGAP method might offer a general and facile platform for mass production of hydrophobic pharmaceutical danazol particles in nanometer range.

Key words: high-gravity antisolvent precipitation,rotating packed bed, danazol,nanoparticles,dissolution rate

摘要： The nanoparticles of the hydrophobic drug of danazol with narrow size distribution are facilely prepared by controlled high-gravity anti-solvent precipitation(HGAP) process.Intensified micromixing and uniform nucleation environment are created by the high-gravity equipment(rotating packed bed) in carrying out the anti-solvent precipitation process to produce nanoparticles.The average particle size decreases from 55 μm of the raw danazol to 190 nm of the nanoparticles.The Brunauer-Emmett-Teller(BET) surface area sharply increases from 0.66 m²·g^-1 to 15.08 m²·g^-1.Accordingly,the dissolution rate is greatly improved.The molecular state,chemical composition,and crystal form of the danazol nanoparticles remains unchanged after processing according to Fourier transform infrared(FTIR) and X-ray diffraction(XRD).The high recovery ratio and continuous production capacity are highly appreciated in industry.Therefore,the HGAP method might offer a general and facile platform for mass production of hydrophobic pharmaceutical danazol particles in nanometer range.

关键词: high-gravity antisolvent precipitation,rotating packed bed, danazol,nanoparticles,dissolution rate

ZHAO Hong, WANG Jiexin, ZHANG Haixia, SHEN Zhigang, Jimmy Yun, CHEN Jianfeng. Facile Preparation of Danazol Nanoparticles by High-Gravity Anti-solvent Precipitation(HGAP) Method[J]. , 2009, 17(2): 318-323.

赵宏, 王洁欣, 张海霞, 沈志刚, 甄崇礼, 陈建峰. Facile Preparation of Danazol Nanoparticles by High-Gravity Anti-solvent Precipitation(HGAP) Method[J]. , 2009, 17(2): 318-323.

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Facile Preparation of Danazol Nanoparticles by High-Gravity Anti-solvent Precipitation(HGAP) Method

Facile Preparation of Danazol Nanoparticles by High-Gravity Anti-solvent Precipitation(HGAP) Method

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