SCI和EI收录∣中国化工学会会刊

›› 2009, Vol. 17 ›› Issue (2): 344-349.

• RESEARCH NOTES • Previous Articles     Next Articles

Carotenoids Particle Formation by Supercritical Fluid Technologies

QUAN Can1, Johan Carlfors2, Charlotta Turner3   

  1. 1. Division of Chemistry, National Institute of Metrology, Beijing 100013, China;
    2. Department of Pharmaceutics, Faculty of Pharmacy, Uppsala University, Uppsala, SE75123, Sweden;
    3. Department of Analytical Chemistry, Uppsala University, Uppsala, SE75124, Sweden
  • Received:2008-04-14 Revised:2009-02-17 Online:2009-04-28 Published:2009-04-28
  • Supported by:
    Supported partially by the China Ministry of Science and Technology for the China's Agenda 21 Strategic Research (MOST,2008IM021900);the General Administration of Quality Supervision Inspection and Quarantine of the People's Republic of China for the 4th Food Safety Research (AQSIQ 2008:ASPAQ0809)

Carotenoids Particle Formation by Supercritical Fluid Technologies

全灿1, Johan Carlfors2, Charlotta Turner3   

  1. 1. Division of Chemistry, National Institute of Metrology, Beijing 100013, China;
    2. Department of Pharmaceutics, Faculty of Pharmacy, Uppsala University, Uppsala, SE75123, Sweden;
    3. Department of Analytical Chemistry, Uppsala University, Uppsala, SE75124, Sweden
  • 通讯作者: Charlotta Turner,E-mail:charlotta.turner@kemi.uu.se
  • 基金资助:
    Supported partially by the China Ministry of Science and Technology for the China's Agenda 21 Strategic Research (MOST,2008IM021900);the General Administration of Quality Supervision Inspection and Quarantine of the People's Republic of China for the 4th Food Safety Research (AQSIQ 2008:ASPAQ0809)

Abstract: Based on the solubility in supercritical CO2,two strategies in which CO2 plays different roles are used to make quercetine and astaxanthin particles by supercritical fluid technologies.The experimental results showed that micronized quercetine particles with mean particle size of 1.0-1.5 μm can be made via solution enhanced dispersion by supercritical fluids(SEDS) process,in which CO2 worked as turbulent anti-solvent;while for astaxanthin,micronized particles with mean particle size of 0.3-0.8 μm were also made successfully by rapid expansion supercritical solution(RESS) process.

Key words: quercetine, astaxanthin, rapid expansion of supercritical solution, solution enhanced dispersion by supercritical fluids, particle formation

摘要: Based on the solubility in supercritical CO2,two strategies in which CO2 plays different roles are used to make quercetine and astaxanthin particles by supercritical fluid technologies.The experimental results showed that micronized quercetine particles with mean particle size of 1.0-1.5 μm can be made via solution enhanced dispersion by supercritical fluids(SEDS) process,in which CO2 worked as turbulent anti-solvent;while for astaxanthin,micronized particles with mean particle size of 0.3-0.8 μm were also made successfully by rapid expansion supercritical solution(RESS) process.

关键词: quercetine, astaxanthin, rapid expansion of supercritical solution, solution enhanced dispersion by supercritical fluids, particle formation