Abstract: A new process for the direct chlorination of 2-chloro-5-methylpyridine to yield 2-chloro-5
-chloromethylpyridine in an airlift loop reactor (ALR) has been studied. Five main reaction
conditions including TR,na/ns, cp, Qg and dD/dR were optimized. The average molar yield and
purity of 2-chloro-5-chloromethylpyridine obtained were 79% and 98.5% respectively under
the optimum operating conditions. Finally, the efficiency for the preparation of 2-chloro-
5-chloromethylpyridine with ALR and stirred tank reactor (STR) respectively was compared.

Key words: 2-chloro-5-chloromethylpyridine, 2-chloro-5-methylpyridine, direct chlorination, airlift loop reactor

摘要： A new process for the direct chlorination of 2-chloro-5-methylpyridine to yield 2-chloro-5
-chloromethylpyridine in an airlift loop reactor (ALR) has been studied. Five main reaction
conditions including TR,na/ns, cp, Qg and dD/dR were optimized. The average molar yield and
purity of 2-chloro-5-chloromethylpyridine obtained were 79% and 98.5% respectively under
the optimum operating conditions. Finally, the efficiency for the preparation of 2-chloro-
5-chloromethylpyridine with ALR and stirred tank reactor (STR) respectively was compared.

关键词: 2-chloro-5-chloromethylpyridine;2-chloro-5-methylpyridine;direct chlorination;airlift loop reactor