Modeling of degradation kinetics of Salvianolic acid B at different temperatures and pH values

doi:10.1016/j.cjche.2016.06.005

›› 2017, Vol. 25 ›› Issue (1): 68-73.DOI: 10.1016/j.cjche.2016.06.005

• Catalysis, Kinetics and Reaction Engineering • Previous Articles Next Articles

Modeling of degradation kinetics of Salvianolic acid B at different temperatures and pH values

Xingchu Gong, Shichao Huang, Jianyang Pan, Haibin Qu

Pharmaceutical Informatics Institute, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, China

Received:2016-03-01 Revised:2016-06-08 Online:2017-02-15 Published:2017-01-28
Supported by:
Supported by the National Natural Science Foundation of China (No.81273992) and the Public Service Technology Research and Social Development Project of Science Technology Department of Zhejiang Province of China (2015C33128).

Modeling of degradation kinetics of Salvianolic acid B at different temperatures and pH values

Xingchu Gong, Shichao Huang, Jianyang Pan, Haibin Qu

Pharmaceutical Informatics Institute, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, China

通讯作者: Haibin Qu,E-mail address:quhb@zju.edu.cn
基金资助:
Supported by the National Natural Science Foundation of China (No.81273992) and the Public Service Technology Research and Social Development Project of Science Technology Department of Zhejiang Province of China (2015C33128).

Abstract

Abstract: In this work, the effects of degradation time, temperature, and pH value on the degradation of Salvianolic acid B in aqueous solution were determined. Higher pH values, higher extraction temperature, and longer extraction time led to more degradation of Salvianolic acid B. Danshensu concentration increased as Salvianolic acid B degraded. A mechanism model was developed considering the degradation of Salvianolic acid E and lithospermic acid, which were two degradation products of Salvianolic acid B. The reverse reactions of Salvianolic acid B degradation were also considered. Degradation kinetic constants were calibrated. The degradation kinetics of Salvianolic acid B, lithospermic acid, and Danshensu in a Salvia miltiorrhiza extract aqueous solution were predicted using the mechanism model. The predicted concentrations agreed well with the experimental results. This model was developed using degradation data obtained from simple composition systems, but it can be applied in a complex botanical mixture with high prediction accuracy.

Key words: Danshen, Modeling, Hydrolysis, Salvianolic acid B

摘要： In this work, the effects of degradation time, temperature, and pH value on the degradation of Salvianolic acid B in aqueous solution were determined. Higher pH values, higher extraction temperature, and longer extraction time led to more degradation of Salvianolic acid B. Danshensu concentration increased as Salvianolic acid B degraded. A mechanism model was developed considering the degradation of Salvianolic acid E and lithospermic acid, which were two degradation products of Salvianolic acid B. The reverse reactions of Salvianolic acid B degradation were also considered. Degradation kinetic constants were calibrated. The degradation kinetics of Salvianolic acid B, lithospermic acid, and Danshensu in a Salvia miltiorrhiza extract aqueous solution were predicted using the mechanism model. The predicted concentrations agreed well with the experimental results. This model was developed using degradation data obtained from simple composition systems, but it can be applied in a complex botanical mixture with high prediction accuracy.

关键词: Danshen, Modeling, Hydrolysis, Salvianolic acid B

Xingchu Gong, Shichao Huang, Jianyang Pan, Haibin Qu. Modeling of degradation kinetics of Salvianolic acid B at different temperatures and pH values[J]. , 2017, 25(1): 68-73.

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Modeling of degradation kinetics of Salvianolic acid B at different temperatures and pH values

Modeling of degradation kinetics of Salvianolic acid B at different temperatures and pH values

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