Chinese Journal of Chemical Engineering ›› 2020, Vol. 28 ›› Issue (2): 598-602.doi: 10.1016/j.cjche.2019.01.029

• Materials and Product Engineering • Previous Articles     Next Articles

Preparation and characterization of the n-HA/PVA/CS porous composite hydrogel

Wei Liang, Zhongkuan Luo, Li Zhou   

  1. College of Chemistry and Environmental Engineering, Shenzhen University, Shenzhen 518055, China
  • Received:2017-12-26 Revised:2019-01-13 Online:2020-02-28 Published:2020-05-21
  • Contact: Li Zhou
  • Supported by:
    Supported by the Key Technology R&D Program of Shenzhen Municipal (JSGG20120614164013545) and Basic Research Program of Shenzhen Municipal (JCYJ20130329102614715).

Abstract: In this paper, a new method combines chemical/physical crosslinking, and emulsification-foaming porogenic was adopted to prepare n-hydroxyapatite (n-HA)/polyvinyl alcohol (PVA)/chitosan (CS) porous composite hydrogel using artificial cornea scaffold materials. The fabricate conditions, including the type and amount of emulsification-foaming porogen, mixing time and speed etc. were researched. The results showed the optimal condition that the alkylphenol polyoxyethylene ether (OP) acted as emulsification-foaming porogen, with the ratio of WPVA/WOP as 3.75, and mixing 15 min with a stirring speed of 800 r·min-1. Additionally, the fabricated composite hydrogel scaffold materials possessed interconnected internal holes, a moisture content of above 65%, and tensile strength of above 6 MPa. In vitro cytotoxicity and acute systemic toxicity assay confirmed that the scaffolds did not show any cytotoxicity. The as-prepared hydrogel could be a promising candidate for artificial cornea scaffold material.

Key words: Porous composite hydrogel, Chemical/physical crosslinking, Emulsification-foaming porogen, Polyvinyl alcohol, Biocompatibility, Artificial cornea scaffold