Impact of oxygen supply on production of terpenoids by microorganisms: State of the art

doi:10.1016/j.cjche.2020.12.006

Chinese Journal of Chemical Engineering ›› 2021, Vol. 29 ›› Issue (2): 46-53.DOI: 10.1016/j.cjche.2020.12.006

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Impact of oxygen supply on production of terpenoids by microorganisms: State of the art

Ting-Ting Liu¹, Han Xiao¹, Jian-Hui Xiao², Jian-Jiang Zhong¹

1 State Key Laboratory of Microbial Metabolism, Joint International Research Laboratory of Metabolic and Developmental Sciences, Laboratory of Molecular Biochemical Engineering and Advanced Fermentation Technology, Department of Bioengineering, School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, Shanghai 200240, China;
2 Zunyi Municipal Key Laboratory of Medicinal Biotechnology, Center for Translational Medicine, Affiliated Hospital of Zunyi Medical University, Zunyi 563003, China

Received:2020-09-26 Revised:2020-12-03 Online:2021-05-15 Published:2021-02-28
Contact: Jian-Hui Xiao, Jian-Jiang Zhong
Supported by:
This work was supported by the National Key R&D Program of China (Nos. 2019YFA0904800 and 2018YFA0901900) and the National Natural Science Foundation of China (No. 31770037). The authors also appreciate Prof. Yan Sun for his kind invitation to this special issue.

Impact of oxygen supply on production of terpenoids by microorganisms: State of the art

Ting-Ting Liu¹, Han Xiao¹, Jian-Hui Xiao², Jian-Jiang Zhong¹

1 State Key Laboratory of Microbial Metabolism, Joint International Research Laboratory of Metabolic and Developmental Sciences, Laboratory of Molecular Biochemical Engineering and Advanced Fermentation Technology, Department of Bioengineering, School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, Shanghai 200240, China;
2 Zunyi Municipal Key Laboratory of Medicinal Biotechnology, Center for Translational Medicine, Affiliated Hospital of Zunyi Medical University, Zunyi 563003, China

通讯作者: Jian-Hui Xiao, Jian-Jiang Zhong
基金资助:
This work was supported by the National Key R&D Program of China (Nos. 2019YFA0904800 and 2018YFA0901900) and the National Natural Science Foundation of China (No. 31770037). The authors also appreciate Prof. Yan Sun for his kind invitation to this special issue.

Abstract

Abstract: Terpenoids are a class of high value-added natural products with a variety of biological functions. Genetically engineered microorganisms, such as those of Escherichia coli and Saccharomyces cerevisiae, have merits in producing plant or fungus-derived terpenoids, due to their mature genetic manipulation, simple nutrient demand and fast growth. Oxygen, as a key environmental factor, is particularly important to microbial metabolism and growth, and suitable oxygen supply is viewed as a prerequisite for realizing highly efficient production of terpenoids by engineered microorganisms. In this article, the role of oxygen in regulating terpenoid bioproduction is overviewed from the viewpoints of cellular carbon metabolism, energy metabolism and terpenoid anabolism. Strategies on adjusting oxygen availability to microorganisms, including genetic modification of cellular metabolism related with oxygen utilization, are summarized and discussed, to provide helpful information for further improvement of terpenoid biosynthesis by microbes.

Key words: Terpenoid, Microorganisms, Oxygen supply, Chassis modification

摘要： Terpenoids are a class of high value-added natural products with a variety of biological functions. Genetically engineered microorganisms, such as those of Escherichia coli and Saccharomyces cerevisiae, have merits in producing plant or fungus-derived terpenoids, due to their mature genetic manipulation, simple nutrient demand and fast growth. Oxygen, as a key environmental factor, is particularly important to microbial metabolism and growth, and suitable oxygen supply is viewed as a prerequisite for realizing highly efficient production of terpenoids by engineered microorganisms. In this article, the role of oxygen in regulating terpenoid bioproduction is overviewed from the viewpoints of cellular carbon metabolism, energy metabolism and terpenoid anabolism. Strategies on adjusting oxygen availability to microorganisms, including genetic modification of cellular metabolism related with oxygen utilization, are summarized and discussed, to provide helpful information for further improvement of terpenoid biosynthesis by microbes.

关键词: Terpenoid, Microorganisms, Oxygen supply, Chassis modification

Ting-Ting Liu, Han Xiao, Jian-Hui Xiao, Jian-Jiang Zhong. Impact of oxygen supply on production of terpenoids by microorganisms: State of the art[J]. Chinese Journal of Chemical Engineering, 2021, 29(2): 46-53.

Ting-Ting Liu, Han Xiao, Jian-Hui Xiao, Jian-Jiang Zhong. Impact of oxygen supply on production of terpenoids by microorganisms: State of the art[J]. 中国化学工程学报, 2021, 29(2): 46-53.

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Impact of oxygen supply on production of terpenoids by microorganisms: State of the art

Impact of oxygen supply on production of terpenoids by microorganisms: State of the art

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