Green synthesis of multifunctional carbon dots for anti-cancer and anti-fungal applications

doi:10.1016/j.cjche.2021.03.008

Chinese Journal of Chemical Engineering ›› 2021, Vol. 37 ›› Issue (9): 97-104.DOI: 10.1016/j.cjche.2021.03.008

• Biotechnology and Bioengineering • Previous Articles Next Articles

Green synthesis of multifunctional carbon dots for anti-cancer and anti-fungal applications

Shaojing Zhao¹, Li Huang¹, Yong Xie², Bin Wang², Feng Wang³, Minhuan Lan¹

1. Hunan Provincial Key Laboratory of Micro & Nano Materials Interface Science, College of Chemistry and Chemical Engineering, Central South University, Changsha 410083, China;
2. State Key Laboratory of the Discovery and Development of Novel Pesticide, Shenyang Sinochem Agrochemicals R&D Co., Ltd., Shenyang 110021, China;
3. Key Laboratory of Materials Chemistry for Energy Conversion and Storage of Ministry of Education, Hubei Key Laboratory of Material Chemistry and Service Failure, School of Chemistry and Chemical Engineering, Huazhong University of Science and Technology, Wuhan 430074, China

Received:2020-10-02 Revised:2021-02-10 Online:2021-11-02 Published:2021-09-28
Contact: Yong Xie, Minhuan Lan
Supported by:
This work was supported by the National Natural Science Foundation of China (61805287), Natural Science Foundation of Hunan Province, China (2018JJ3632 and 2019JJ50824), Fundamental Research Funds for State Key Laboratory of the Discovery and Development of Novel Pesticide, Shenyang Sinochem Agrochemicals Research and Development Co., Ltd. (2018NYRD02).

Green synthesis of multifunctional carbon dots for anti-cancer and anti-fungal applications

Shaojing Zhao¹, Li Huang¹, Yong Xie², Bin Wang², Feng Wang³, Minhuan Lan¹

1. Hunan Provincial Key Laboratory of Micro & Nano Materials Interface Science, College of Chemistry and Chemical Engineering, Central South University, Changsha 410083, China;
2. State Key Laboratory of the Discovery and Development of Novel Pesticide, Shenyang Sinochem Agrochemicals R&D Co., Ltd., Shenyang 110021, China;
3. Key Laboratory of Materials Chemistry for Energy Conversion and Storage of Ministry of Education, Hubei Key Laboratory of Material Chemistry and Service Failure, School of Chemistry and Chemical Engineering, Huazhong University of Science and Technology, Wuhan 430074, China

通讯作者: Yong Xie, Minhuan Lan
基金资助:
This work was supported by the National Natural Science Foundation of China (61805287), Natural Science Foundation of Hunan Province, China (2018JJ3632 and 2019JJ50824), Fundamental Research Funds for State Key Laboratory of the Discovery and Development of Novel Pesticide, Shenyang Sinochem Agrochemicals Research and Development Co., Ltd. (2018NYRD02).

Abstract

Abstract: Carbon dots (CDs) have become popular nanomaterials in biomedical and agricultural fields. Herein we synthesized multifunctional CDs which showed anti-cancer and anti-fungal activities. The low cytotoxicity, stable fluorescence and high photothermal conversion efficiency enable the CDs with imaging-guided photothermal therapy. The CDs also exhibited intrinsic anti-fungal activity even at a low concentration, i.e., 40 mg·L^-1 of CDs induced 20% mortality in cucumber downy mildew. Moreover, the large π-conjugated nanostructure and the richness of amino and hydroxyl groups make them a powerful delivery platform for flumorph (a fungicide) with a high loading efficiency of 47.18%. Meanwhile, the heat converted from the light can accelerate the release of flumorph from CDs, and thus efficiently kill fungus.

Key words: Carbon dots, Photothermal therapy, Anti-fungus, Delivery, Pesticide

摘要： Carbon dots (CDs) have become popular nanomaterials in biomedical and agricultural fields. Herein we synthesized multifunctional CDs which showed anti-cancer and anti-fungal activities. The low cytotoxicity, stable fluorescence and high photothermal conversion efficiency enable the CDs with imaging-guided photothermal therapy. The CDs also exhibited intrinsic anti-fungal activity even at a low concentration, i.e., 40 mg·L^-1 of CDs induced 20% mortality in cucumber downy mildew. Moreover, the large π-conjugated nanostructure and the richness of amino and hydroxyl groups make them a powerful delivery platform for flumorph (a fungicide) with a high loading efficiency of 47.18%. Meanwhile, the heat converted from the light can accelerate the release of flumorph from CDs, and thus efficiently kill fungus.

关键词: Carbon dots, Photothermal therapy, Anti-fungus, Delivery, Pesticide

Shaojing Zhao, Li Huang, Yong Xie, Bin Wang, Feng Wang, Minhuan Lan. Green synthesis of multifunctional carbon dots for anti-cancer and anti-fungal applications[J]. Chinese Journal of Chemical Engineering, 2021, 37(9): 97-104.

Shaojing Zhao, Li Huang, Yong Xie, Bin Wang, Feng Wang, Minhuan Lan. Green synthesis of multifunctional carbon dots for anti-cancer and anti-fungal applications[J]. 中国化学工程学报, 2021, 37(9): 97-104.

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Green synthesis of multifunctional carbon dots for anti-cancer and anti-fungal applications

Green synthesis of multifunctional carbon dots for anti-cancer and anti-fungal applications

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