Preparation of bowl-shaped polydopamine surface imprinted polymer composite adsorbent for specific separation of 2′-deoxyadenosine

doi:10.1016/j.cjche.2023.01.009

Chinese Journal of Chemical Engineering ›› 2023, Vol. 60 ›› Issue (8): 69-79.DOI: 10.1016/j.cjche.2023.01.009

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Preparation of bowl-shaped polydopamine surface imprinted polymer composite adsorbent for specific separation of 2′-deoxyadenosine

Pan Wang, Mengdei Zhou, Zhuangxin Wei, Lu Liu, Tao Cheng, Xiaohua Tian, Jianming Pan

School of Chemistry and Chemical Engineering, Jiangsu University, Zhenjiang 212013, China

Received:2022-09-03 Revised:2023-01-13 Online:2023-10-28 Published:2023-08-28
Contact: Jianming Pan,E-mail:pjm@ujs.edu.cn
Supported by:
This work was financially supported by the National Natural Science Foundation of China (22078132 and 22108103), Open Funding Project of the National Key Laboratory of Biochemical Engineering (2021KF-02), China Postdoctoral Science Foundation (2021M691301), Jiangsu Agricultural Independent Innovation Fund Project (CX(21)3079) and Graduate Research Innovation Program of Jiangsu Province (KYCX20-3040), China Postdoctoral Science Foundation (2021M691301).

Preparation of bowl-shaped polydopamine surface imprinted polymer composite adsorbent for specific separation of 2′-deoxyadenosine

Pan Wang, Mengdei Zhou, Zhuangxin Wei, Lu Liu, Tao Cheng, Xiaohua Tian, Jianming Pan

School of Chemistry and Chemical Engineering, Jiangsu University, Zhenjiang 212013, China

通讯作者: Jianming Pan,E-mail:pjm@ujs.edu.cn
基金资助:
This work was financially supported by the National Natural Science Foundation of China (22078132 and 22108103), Open Funding Project of the National Key Laboratory of Biochemical Engineering (2021KF-02), China Postdoctoral Science Foundation (2021M691301), Jiangsu Agricultural Independent Innovation Fund Project (CX(21)3079) and Graduate Research Innovation Program of Jiangsu Province (KYCX20-3040), China Postdoctoral Science Foundation (2021M691301).

Abstract

Abstract: Molecularly imprinted polymers (MIPs) have great potential as adsorbents for selective adsorption and separation of nucleoside compounds, but effectively enhancing the affinity of recognition sites by adjusting the forces between template molecules and functional monomers remains an important challenge. In this work, a surface imprinting strategy was used to construct bowl-shaped molecularly imprinted composite sorbents (BHPN@MIPs) based on polydopamine (PDA) particles and have achieved selective separation and purification of 2'-deoxyadenosine (dA). Where by the base complementary pairing interaction of the combined template molecule dA and the pyrimidine functional monomer can enhance the pre-assembly force, and the hydrophilic bowl-shaped PDA can provide a larger storage space contact efficiency of dA in the test solution, causing the site utilization much higher and improving the kinetic adsorption performance. The equilibrium adsorption time and maximum adsorption capacity of 60 min and 328.45 μmol·g^-1 were observed by static adsorption experiments, and the selectivity experimental results showed an imprinting factor IF of 1.30. After four adsorption-desorption cycles, the initial adsorption equilibrium adsorption capacity of BHPN@MIPs still retained 91.14%. By evaluating the selective adsorption of dA in spiked human serum solutions, BHPN@MIPs can be used to selectively enrich and analyze target dA in complex biological samples.

Key words: Molecularly imprinted polymers (MIPs), Bowl-shaped, Base complementary pairing interaction, Selective separation 2′-deoxyadenosine (dA)

摘要： Molecularly imprinted polymers (MIPs) have great potential as adsorbents for selective adsorption and separation of nucleoside compounds, but effectively enhancing the affinity of recognition sites by adjusting the forces between template molecules and functional monomers remains an important challenge. In this work, a surface imprinting strategy was used to construct bowl-shaped molecularly imprinted composite sorbents (BHPN@MIPs) based on polydopamine (PDA) particles and have achieved selective separation and purification of 2'-deoxyadenosine (dA). Where by the base complementary pairing interaction of the combined template molecule dA and the pyrimidine functional monomer can enhance the pre-assembly force, and the hydrophilic bowl-shaped PDA can provide a larger storage space contact efficiency of dA in the test solution, causing the site utilization much higher and improving the kinetic adsorption performance. The equilibrium adsorption time and maximum adsorption capacity of 60 min and 328.45 μmol·g^-1 were observed by static adsorption experiments, and the selectivity experimental results showed an imprinting factor IF of 1.30. After four adsorption-desorption cycles, the initial adsorption equilibrium adsorption capacity of BHPN@MIPs still retained 91.14%. By evaluating the selective adsorption of dA in spiked human serum solutions, BHPN@MIPs can be used to selectively enrich and analyze target dA in complex biological samples.

关键词: Molecularly imprinted polymers (MIPs), Bowl-shaped, Base complementary pairing interaction, Selective separation 2′-deoxyadenosine (dA)

Pan Wang, Mengdei Zhou, Zhuangxin Wei, Lu Liu, Tao Cheng, Xiaohua Tian, Jianming Pan. Preparation of bowl-shaped polydopamine surface imprinted polymer composite adsorbent for specific separation of 2′-deoxyadenosine[J]. Chinese Journal of Chemical Engineering, 2023, 60(8): 69-79.

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Preparation of bowl-shaped polydopamine surface imprinted polymer composite adsorbent for specific separation of 2′-deoxyadenosine

Preparation of bowl-shaped polydopamine surface imprinted polymer composite adsorbent for specific separation of 2′-deoxyadenosine

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