Pickering emulsion transport in skeletal muscle tissue: A dissipative particle dynamics simulation approach

doi:10.1016/j.cjche.2024.01.002

Chinese Journal of Chemical Engineering ›› 2024, Vol. 68 ›› Issue (4): 65-75.DOI: 10.1016/j.cjche.2024.01.002

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Pickering emulsion transport in skeletal muscle tissue: A dissipative particle dynamics simulation approach

Xuwei Liu^1,2, Wei Chen^1,4,5, Yufei Xia^3,4,5, Guanghui Ma^3,4,5, Reiji Noda², Wei Ge^1,2,4,5

1. State Key Laboratory of Mesoscience and Engineering, Institute of Process Engineering, Chinese Academy of Sciences, Beijing 100190, China;
2. Division of Environmental Engineering Science, Graduate School of Science and Technology, Gunma University, 1-5-1 Tenjin-cho, Kiryu, Gunma 376-8515, Japan;
3. State Key Laboratory of Biochemical Engineering, Institute of Process Engineering, Chinese Academy of Sciences, Beijing 100190, China;
4. School of Chemical Engineering, University of Chinese Academy of Sciences, Beijing 100049, China;
5. Innovation Academy for Green Manufacture, Chinese Academy of Sciences, Beijing 100190, China

Received:2023-11-07 Revised:2024-01-02 Online:2024-06-28 Published:2024-04-28
Contact: Wei Chen,E-mail address:chenwei@ipe.ac.cn;Yufei Xia,E-mail address:yfxia@ipe.ac.cn
Supported by:
This study is financially supported by the National Natural Science Foundation of China (22373104 and 22293024) and the Science Fund for Creative Research Groups of the National Natural Science Foundation of China (21821005). This study is also supported by the National Key Research and Development Program of China (2021YFE020527). Yufei Xia is grateful for the support by the Distinguished Young Scholars of the National Natural Science Foundation of China (T2222022). We also acknowledge the computational resources provided by upgraded Mole-8.5E supercomputing system developed by Institute of Process Engineering, Chinese Academy of Sciences.

Pickering emulsion transport in skeletal muscle tissue: A dissipative particle dynamics simulation approach

Xuwei Liu^1,2, Wei Chen^1,4,5, Yufei Xia^3,4,5, Guanghui Ma^3,4,5, Reiji Noda², Wei Ge^1,2,4,5

1. State Key Laboratory of Mesoscience and Engineering, Institute of Process Engineering, Chinese Academy of Sciences, Beijing 100190, China;
2. Division of Environmental Engineering Science, Graduate School of Science and Technology, Gunma University, 1-5-1 Tenjin-cho, Kiryu, Gunma 376-8515, Japan;
3. State Key Laboratory of Biochemical Engineering, Institute of Process Engineering, Chinese Academy of Sciences, Beijing 100190, China;
4. School of Chemical Engineering, University of Chinese Academy of Sciences, Beijing 100049, China;
5. Innovation Academy for Green Manufacture, Chinese Academy of Sciences, Beijing 100190, China

通讯作者: Wei Chen,E-mail address:chenwei@ipe.ac.cn;Yufei Xia,E-mail address:yfxia@ipe.ac.cn
基金资助:
This study is financially supported by the National Natural Science Foundation of China (22373104 and 22293024) and the Science Fund for Creative Research Groups of the National Natural Science Foundation of China (21821005). This study is also supported by the National Key Research and Development Program of China (2021YFE020527). Yufei Xia is grateful for the support by the Distinguished Young Scholars of the National Natural Science Foundation of China (T2222022). We also acknowledge the computational resources provided by upgraded Mole-8.5E supercomputing system developed by Institute of Process Engineering, Chinese Academy of Sciences.

Abstract

Abstract: Lymph node targeting is a commonly used strategy for particulate vaccines, particularly for Pickering emulsions. However, extensive research on the internal delivery mechanisms of these emulsions, especially the complex intercellular interactions of deformable Pickering emulsions, has been surprisingly sparse. This gap in knowledge holds significant potential for enhancing vaccine efficacy. This study aims to address this by summarizing the process of lymph-node-targeting transport and introducing a dissipative particle dynamics simulation method to evaluate the dynamic processes within cell tissue. The transport of Pickering emulsions in skeletal muscle tissue is specifically investigated as a case study. Various factors impacting the transport process are explored, including local cellular tissue environmental factors and the properties of the Pickering emulsion itself. The simulation results primarily demonstrate that an increase in radial repulsive interaction between emulsion particles can decrease the transport efficiency. Additionally, larger intercellular gaps also diminish the transport efficiency of emulsion droplet particles due to the increased motion complexity within the intricate transport space compared to a single channel. This study sheds light on the nuanced interplay between engineered and biological systems influencing the transport dynamics of Pickering emulsions. Such insights hold valuable potential for optimizing transport processes in practical biomedical applications such as drug delivery. Importantly, the desired transport efficiency varies depending on the specific application. For instance, while a more rapid transport might be crucial for lymph-node-targeted drug delivery, certain applications requiring a slower release of active components could benefit from the reduced transport efficiency observed with increased particle repulsion or larger intercellular gaps.

Key words: Pickering emulsion, Skeletal muscular cells, Transport phenomena, Dissipative particle dynamics, Drug delivery

摘要： Lymph node targeting is a commonly used strategy for particulate vaccines, particularly for Pickering emulsions. However, extensive research on the internal delivery mechanisms of these emulsions, especially the complex intercellular interactions of deformable Pickering emulsions, has been surprisingly sparse. This gap in knowledge holds significant potential for enhancing vaccine efficacy. This study aims to address this by summarizing the process of lymph-node-targeting transport and introducing a dissipative particle dynamics simulation method to evaluate the dynamic processes within cell tissue. The transport of Pickering emulsions in skeletal muscle tissue is specifically investigated as a case study. Various factors impacting the transport process are explored, including local cellular tissue environmental factors and the properties of the Pickering emulsion itself. The simulation results primarily demonstrate that an increase in radial repulsive interaction between emulsion particles can decrease the transport efficiency. Additionally, larger intercellular gaps also diminish the transport efficiency of emulsion droplet particles due to the increased motion complexity within the intricate transport space compared to a single channel. This study sheds light on the nuanced interplay between engineered and biological systems influencing the transport dynamics of Pickering emulsions. Such insights hold valuable potential for optimizing transport processes in practical biomedical applications such as drug delivery. Importantly, the desired transport efficiency varies depending on the specific application. For instance, while a more rapid transport might be crucial for lymph-node-targeted drug delivery, certain applications requiring a slower release of active components could benefit from the reduced transport efficiency observed with increased particle repulsion or larger intercellular gaps.

关键词: Pickering emulsion, Skeletal muscular cells, Transport phenomena, Dissipative particle dynamics, Drug delivery

Xuwei Liu, Wei Chen, Yufei Xia, Guanghui Ma, Reiji Noda, Wei Ge. Pickering emulsion transport in skeletal muscle tissue: A dissipative particle dynamics simulation approach[J]. Chinese Journal of Chemical Engineering, 2024, 68(4): 65-75.

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Pickering emulsion transport in skeletal muscle tissue: A dissipative particle dynamics simulation approach

Pickering emulsion transport in skeletal muscle tissue: A dissipative particle dynamics simulation approach

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