Current advances in distillation processes for fermentative acetone-butanol-ethanol purification

doi:10.1016/j.cjche.2024.08.014

Chinese Journal of Chemical Engineering ›› 2025, Vol. 79 ›› Issue (3): 91-108.DOI: 10.1016/j.cjche.2024.08.014

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Current advances in distillation processes for fermentative acetone-butanol-ethanol purification

Xuedan Hou¹, Pengfei Zhao¹, Xiaohui Lin¹, Yunxing Gao², Huidong Chen^3,4, Di Cai³, Peiyong Qin⁵

1. School of Biomedical and Pharmaceutical Science, Guangdong University of Technology, Guangzhou 510006, China;
2. Beijing Key Lab of Bioprocess, College of Life Science and Technology, Beijing University of Chemical Technology, Beijing 100029, China;
3. National Energy R&D Center for Biorefinery, Beijing University of Chemical Technology, Beijing 100029, China;
4. High-Tech Research Institute, Beijing University of Chemical Technology, Beijing 100029, China;
5. College of Life Science and Technology, Beijing University of Chemical Technology, Beijing 100029, China

Received:2024-05-30 Revised:2024-07-14 Accepted:2024-08-04 Online:2025-01-10 Published:2025-03-28
Supported by:
This work was funded by the National Natural Science Foundation of China (22078018), and the Natural Science Foundation of Beijing (2222016).

Current advances in distillation processes for fermentative acetone-butanol-ethanol purification

Xuedan Hou¹, Pengfei Zhao¹, Xiaohui Lin¹, Yunxing Gao², Huidong Chen^3,4, Di Cai³, Peiyong Qin⁵

1. School of Biomedical and Pharmaceutical Science, Guangdong University of Technology, Guangzhou 510006, China;
2. Beijing Key Lab of Bioprocess, College of Life Science and Technology, Beijing University of Chemical Technology, Beijing 100029, China;
3. National Energy R&D Center for Biorefinery, Beijing University of Chemical Technology, Beijing 100029, China;
4. High-Tech Research Institute, Beijing University of Chemical Technology, Beijing 100029, China;
5. College of Life Science and Technology, Beijing University of Chemical Technology, Beijing 100029, China

通讯作者: Huidong Chen,E-mail:chenhdbuct@163.com;Di Cai,E-mail:caidibuct@163.com;Peiyong Qin,E-mail:qinpeiyong@tsinghua.org.cn
基金资助:
This work was funded by the National Natural Science Foundation of China (22078018), and the Natural Science Foundation of Beijing (2222016).

Abstract

Abstract: Acetone-butanol-ethanol (ABE) fermentation is a primary strategy for producing bio-based n-butanol from abundant renewable biomass. In the typical ABE production chain, distillation is an essential unit for high purity A-B-E productions, but has long been criticized by the energy-inefficient processes due to the extremely low solvents concentration received in the upstream fermentation system. Over the past decades, efforts have been dedicated to developing eco-efficient ABE distillation processes aimed at reducing both energy costs and capital investments. In this review, a comprehensive overview on ABE distillation systems is provided from physico-chemical properties in feed and thermodynamics to the process constructions and applications. The recent trends in distillation sequence construction that fitting with the rapid developed upstream in situ product recovery (ISPR) systems are emphasized. Furthermore, towards developing a more efficient ABE distillation system, the review takes a broad overview of the intensification strategies for ABE distillation. Along with systematic introduction of the key examples, the future directions for ABE distillation techniques development are also discussed towards a sustainable and low-carbon emission biorefineries.

Key words: n-Butanol, ABE fermentation, In situ product recovery, Distillation, Process intensification

摘要： Acetone-butanol-ethanol (ABE) fermentation is a primary strategy for producing bio-based n-butanol from abundant renewable biomass. In the typical ABE production chain, distillation is an essential unit for high purity A-B-E productions, but has long been criticized by the energy-inefficient processes due to the extremely low solvents concentration received in the upstream fermentation system. Over the past decades, efforts have been dedicated to developing eco-efficient ABE distillation processes aimed at reducing both energy costs and capital investments. In this review, a comprehensive overview on ABE distillation systems is provided from physico-chemical properties in feed and thermodynamics to the process constructions and applications. The recent trends in distillation sequence construction that fitting with the rapid developed upstream in situ product recovery (ISPR) systems are emphasized. Furthermore, towards developing a more efficient ABE distillation system, the review takes a broad overview of the intensification strategies for ABE distillation. Along with systematic introduction of the key examples, the future directions for ABE distillation techniques development are also discussed towards a sustainable and low-carbon emission biorefineries.

关键词: n-Butanol, ABE fermentation, In situ product recovery, Distillation, Process intensification

Xuedan Hou, Pengfei Zhao, Xiaohui Lin, Yunxing Gao, Huidong Chen, Di Cai, Peiyong Qin. Current advances in distillation processes for fermentative acetone-butanol-ethanol purification[J]. Chinese Journal of Chemical Engineering, 2025, 79(3): 91-108.

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Current advances in distillation processes for fermentative acetone-butanol-ethanol purification

Current advances in distillation processes for fermentative acetone-butanol-ethanol purification

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