Diffusion Coefficients of L-Arginine in Non-Newtonian Fluid

Abstract

Abstract: L-Arginine is an important component of amino acid injection.Its diffusion in body fluid and blood is of key importance to understand drug diffusion and drug release.As a fundamental demand for study and being a considerably valuable reference for application,in this study,the diffusion coefficients of L-arginine in polyacrylamide(PAM) aqueous solution used as non-Newtonian fluid similar to blood and body fluid were measured using a holographic interferometer.The effects of interaction among molecules and solution concentration on diffusion were analyzed and discussed,respectively.Based on the obstruction-scaling model,a novel modified model was presented for predicting diffusivity of solute in non-Newtonian fluid.Good agreement was achieved between the calculated value and the experimental data.

Key words: L-arginine, diffusion coefficient, holographic interferometer, non-Newtonian fluid, obstruction-scaling model

摘要： L-Arginine is an important component of amino acid injection.Its diffusion in body fluid and blood is of key importance to understand drug diffusion and drug release.As a fundamental demand for study and being a considerably valuable reference for application,in this study,the diffusion coefficients of L-arginine in polyacrylamide(PAM) aqueous solution used as non-Newtonian fluid similar to blood and body fluid were measured using a holographic interferometer.The effects of interaction among molecules and solution concentration on diffusion were analyzed and discussed,respectively.Based on the obstruction-scaling model,a novel modified model was presented for predicting diffusivity of solute in non-Newtonian fluid.Good agreement was achieved between the calculated value and the experimental data.

关键词: L-arginine, diffusion coefficient, holographic interferometer, non-Newtonian fluid, obstruction-scaling model

ZHU Chunying, MA Youguang, JI Xiyan. Diffusion Coefficients of L-Arginine in Non-Newtonian Fluid[J]. , 2008, 16(6): 856-860.

朱春英, 马友光, 季喜燕. Diffusion Coefficients of L-Arginine in Non-Newtonian Fluid[J]. , 2008, 16(6): 856-860.

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