Determination of Paclitaxel Solubility in Carbon Dioxide Using Quartz Crystal Microbalance

Abstract

Abstract: A quartz crystal microbalance (QCM) is used to determine the phase equilibrium of paclitaxel-carbon dioxide system in the pressure range of 0-11 MPa and at temperatures of 35℃,40℃ and 45℃.The experimental results indicated that gaseous CO₂ could be absorbed poorly into paclitaxel.The swelling of paclitaxel film in CO₂ was observed before paclitaxel dissolved into supercritical carbon dioxide (ScCO₂) with the increase of pressure.It was found that ScCO₂ was not a good solvent for paclitaxel.The mole fraction of paclitaxel in ScCO₂ was in the range of (4.5×10^-9)-(7.8×10^-9) under all our experimental conditions.Therefore,a much higher pressure than the CO₂ supercritical point and/or a cosolvent must be used in any processes wherever paclitaxel dissolution in ScCO₂ is required.

Key words: paclitaxel, carbon dioxide, phase behavior, quartz crystal microbalance

摘要： A quartz crystal microbalance (QCM) is used to determine the phase equilibrium of paclitaxel-carbon dioxide system in the pressure range of 0-11 MPa and at temperatures of 35℃,40℃ and 45℃.The experimental results indicated that gaseous CO₂ could be absorbed poorly into paclitaxel.The swelling of paclitaxel film in CO₂ was observed before paclitaxel dissolved into supercritical carbon dioxide (ScCO₂) with the increase of pressure.It was found that ScCO₂ was not a good solvent for paclitaxel.The mole fraction of paclitaxel in ScCO₂ was in the range of (4.5×10^-9)-(7.8×10^-9) under all our experimental conditions.Therefore,a much higher pressure than the CO₂ supercritical point and/or a cosolvent must be used in any processes wherever paclitaxel dissolution in ScCO₂ is required.

关键词: paclitaxel, carbon dioxide, phase behavior, quartz crystal microbalance

JIAO Zhen, CHEN Zhiming, WU Youting, MA Shaoling. Determination of Paclitaxel Solubility in Carbon Dioxide Using Quartz Crystal Microbalance[J]. , 2011, 19(2): 227-231.

焦真, 陈志明, 吴有庭, 马少玲. Determination of Paclitaxel Solubility in Carbon Dioxide Using Quartz Crystal Microbalance[J]. , 2011, 19(2): 227-231.

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