Abstract: 4-Bromo-3-methylanisole is mainly used to synthesize black fluorane dye (2-anilino-3-methyl-6- dibutylaminofluorane, ODB-2), which is one of the most important heat and pressure-sensitive dyes in the manufacture of thermal papers. Compared to the industrial heterogeneous batch process, a continuous homogeneous bromination technology in a modular microreaction system has been developed, and 4-bromo-3-methylanisole has been successfully prepared through high-selective mono-bromination of 3-methylanisole with Br₂ solution in CHCl₃. In optimal conditions, the content of bis-brominated byproducts can be controlled less than 0.5%, which is superior to the industrial standard with 99.5% 3-methylanisole conversion at very short residence time and mild reaction temperature.

Key words: 4-bromo-3-methylanisole, bromination, continuous synthesis, modular microreaction system, mixing enhancement

摘要： 4-Bromo-3-methylanisole is mainly used to synthesize black fluorane dye (2-anilino-3-methyl-6- dibutylaminofluorane, ODB-2), which is one of the most important heat and pressure-sensitive dyes in the manufacture of thermal papers. Compared to the industrial heterogeneous batch process, a continuous homogeneous bromination technology in a modular microreaction system has been developed, and 4-bromo-3-methylanisole has been successfully prepared through high-selective mono-bromination of 3-methylanisole with Br₂ solution in CHCl₃. In optimal conditions, the content of bis-brominated byproducts can be controlled less than 0.5%, which is superior to the industrial standard with 99.5% 3-methylanisole conversion at very short residence time and mild reaction temperature.

关键词: 4-bromo-3-methylanisole, bromination, continuous synthesis, modular microreaction system, mixing enhancement