Measurement and correlation of solubility of meropenem trihydrate in binary (water + acetone/tetrahydrofuran) solvent mixtures

doi:10.1016/j.cjche.2017.05.002

›› 2017, Vol. 25 ›› Issue (10): 1461-1466.DOI: 10.1016/j.cjche.2017.05.002

• Chemical Engineering Thermodynamics • Previous Articles Next Articles

Measurement and correlation of solubility of meropenem trihydrate in binary (water + acetone/tetrahydrofuran) solvent mixtures

Lina Zhou^1,2, Shichao Du^1,2, Ting Wang^1,2, Songgu Wu^1,2, Zhiqiang Guo³, Zhao Wang^1,2, Ling Zhou^1,2

1 School of Chemical Engineering and Technology, State Key Laboratory of Chemical Engineering, Tianjin University, Tianjin 300072, China;
2 The Co-Innovation Center of Chemistry and Chemical Engineering of Tianjin, Tianjin 300072, China;
3 Tianjin Pharmaceuticals Research Institute Co. Ltd, Tianjin 300000, China

Received:2016-08-30 Revised:2017-05-16 Online:2017-06-29 Published:2017-10-28
Supported by:
Supported by Tianjin Municipal Natural Science Foundation (16JCYBJC19500) and China Ministry of Science and Major National Scientific Instrument Development Project (2016YFF0102503).

Measurement and correlation of solubility of meropenem trihydrate in binary (water + acetone/tetrahydrofuran) solvent mixtures

Lina Zhou^1,2, Shichao Du^1,2, Ting Wang^1,2, Songgu Wu^1,2, Zhiqiang Guo³, Zhao Wang^1,2, Ling Zhou^1,2

1 School of Chemical Engineering and Technology, State Key Laboratory of Chemical Engineering, Tianjin University, Tianjin 300072, China;
2 The Co-Innovation Center of Chemistry and Chemical Engineering of Tianjin, Tianjin 300072, China;
3 Tianjin Pharmaceuticals Research Institute Co. Ltd, Tianjin 300000, China

通讯作者: Ling Zhou,E-mail address:zhouling@tju.edu.cn
基金资助:
Supported by Tianjin Municipal Natural Science Foundation (16JCYBJC19500) and China Ministry of Science and Major National Scientific Instrument Development Project (2016YFF0102503).

Abstract

Abstract: The solubility of meropenem trihydrate in water + acetone mixtures and water + tetrahydrofuran mixtures were determined from T=(278.15 to 303.15) K by static method under atmospheric pressure. Effects of solvent composition and temperature on solubility of meropenem trihydrate were discussed. To extend the applicability of the solubility data, experimental solubility data in two kinds of binary solvent mixtures were correlated by the Apelblat equation and NIBS/Redlich-Kister model. It was found that the two models could satisfactorily correlate the experimental data and the Apelblat equation could give better correlation results.

Key words: Solubility, Meropenem trihydrate, Thermodynamics

摘要： The solubility of meropenem trihydrate in water + acetone mixtures and water + tetrahydrofuran mixtures were determined from T=(278.15 to 303.15) K by static method under atmospheric pressure. Effects of solvent composition and temperature on solubility of meropenem trihydrate were discussed. To extend the applicability of the solubility data, experimental solubility data in two kinds of binary solvent mixtures were correlated by the Apelblat equation and NIBS/Redlich-Kister model. It was found that the two models could satisfactorily correlate the experimental data and the Apelblat equation could give better correlation results.

关键词: Solubility, Meropenem trihydrate, Thermodynamics

Lina Zhou, Shichao Du, Ting Wang, Songgu Wu, Zhiqiang Guo, Zhao Wang, Ling Zhou. Measurement and correlation of solubility of meropenem trihydrate in binary (water + acetone/tetrahydrofuran) solvent mixtures[J]. , 2017, 25(10): 1461-1466.

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Measurement and correlation of solubility of meropenem trihydrate in binary (water + acetone/tetrahydrofuran) solvent mixtures

Measurement and correlation of solubility of meropenem trihydrate in binary (water + acetone/tetrahydrofuran) solvent mixtures

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