Effect of different additives on the phase separation behavior and thermodynamics of p-tert-alkylphenoxy poly (oxyethylene) ether in absence and presence of drug

doi:10.1016/j.cjche.2017.10.011

Abstract

Abstract: Cloud point (CP) determinations of 4-(1,1,3,3-tetramethylbutyl)phenyl-polyethylene glycol (TX-100 (nonionic surfactant)) was carried out in aqueous as well as in the attendance of drug (ceftriaxone sodium trihydrate (CFT))/(CFT + different inorganic salts) and discussed thoroughly. Nonionic surfactants are employed extensively in different formulations. In aqueous solution, the values of CP of TX-100 are obtained to increase by means of enhancing of their concentration in the solution. The CP values of TX-100 solutions were found to decrease in the presence of drug and their values decrease more with rising concentrations of the drug. The values of CP of CFT and TX-100 mixtures were found to further decrease in the attendance of inorganic salts in comparison to their absence. The effect of different sodium salts in decreasing CP values of TX-100 was achieved in the following order:NaCO₃ > Na₂SO₄ > NaCl. However, in the case of potassium and ammonium salts, the decreasing order obtained is K₂SO₄ > KCO₃ > KCl and (NH₄)₂SO₄ > Na₂CO₃ > NH₄Cl respectively. Various thermodynamic parameters for example standard free energy (ΔG_c^Θ), standard enthalpy (ΔH_c^Θ) as well as standard entropy (ΔS_c^Θ) changes of phase separation were also evaluated and discussed in detail on the basis of their behavior.

Key words: Cloud point, TX-100, Ceftriaxone sodium trihydrate, Inorganic salts, Thermodynamic parameters

摘要： Cloud point (CP) determinations of 4-(1,1,3,3-tetramethylbutyl)phenyl-polyethylene glycol (TX-100 (nonionic surfactant)) was carried out in aqueous as well as in the attendance of drug (ceftriaxone sodium trihydrate (CFT))/(CFT + different inorganic salts) and discussed thoroughly. Nonionic surfactants are employed extensively in different formulations. In aqueous solution, the values of CP of TX-100 are obtained to increase by means of enhancing of their concentration in the solution. The CP values of TX-100 solutions were found to decrease in the presence of drug and their values decrease more with rising concentrations of the drug. The values of CP of CFT and TX-100 mixtures were found to further decrease in the attendance of inorganic salts in comparison to their absence. The effect of different sodium salts in decreasing CP values of TX-100 was achieved in the following order:NaCO₃ > Na₂SO₄ > NaCl. However, in the case of potassium and ammonium salts, the decreasing order obtained is K₂SO₄ > KCO₃ > KCl and (NH₄)₂SO₄ > Na₂CO₃ > NH₄Cl respectively. Various thermodynamic parameters for example standard free energy (ΔG_c^Θ), standard enthalpy (ΔH_c^Θ) as well as standard entropy (ΔS_c^Θ) changes of phase separation were also evaluated and discussed in detail on the basis of their behavior.

关键词: Cloud point, TX-100, Ceftriaxone sodium trihydrate, Inorganic salts, Thermodynamic parameters

Marzia Rahman, Md. Anamul Hoque, Mohammed Abdullah Khan, Malik Abdul Rub, Abdullah M. Asiri. Effect of different additives on the phase separation behavior and thermodynamics of p-tert-alkylphenoxy poly (oxyethylene) ether in absence and presence of drug[J]. Chin.J.Chem.Eng., 2018, 26(5): 1110-1118.

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