Recent advances in amino acid-metal coordinated nanomaterials for biomedical applications

doi:10.1016/j.cjche.2021.03.013

Abstract

Abstract: Metal and amino acid (AA), as two kinds of entities, have been widely involved in biomaterials and nanomedicines. Recently, the marriage of them has developed new nanoformulations, amino acid-metal coordinated nanomaterials (AMCNs), which show great biomedical application potential in cancer therapy, antibacterial applications, biomedical imaging, etc. With the respective characteristics of metal and AA with rich biological and chemical properties, AMCNs can not only act as drug carriers with specific tumor targeting ability, but also realize synergistic therapy and imaging-guided therapy. Although the design and synthesis of amino acid-metal coordinated nanomaterials have been in-depth investigated, there are few systematic reviews on their biomedical application. In this review, we give a comprehensive summary of recent progresses in the design, fabrication, and biomedical applications of AMCNs. We also propose the future outlooks and challenges in aforementioned field. We expect that this review would contribute some inspiration for future research and development for amino acid metal coordinated nanomaterials.

Key words: Amino acids, Metal, Coordination chemistry, Cancer therapy, Antibacterial applications, Imaging

摘要： Metal and amino acid (AA), as two kinds of entities, have been widely involved in biomaterials and nanomedicines. Recently, the marriage of them has developed new nanoformulations, amino acid-metal coordinated nanomaterials (AMCNs), which show great biomedical application potential in cancer therapy, antibacterial applications, biomedical imaging, etc. With the respective characteristics of metal and AA with rich biological and chemical properties, AMCNs can not only act as drug carriers with specific tumor targeting ability, but also realize synergistic therapy and imaging-guided therapy. Although the design and synthesis of amino acid-metal coordinated nanomaterials have been in-depth investigated, there are few systematic reviews on their biomedical application. In this review, we give a comprehensive summary of recent progresses in the design, fabrication, and biomedical applications of AMCNs. We also propose the future outlooks and challenges in aforementioned field. We expect that this review would contribute some inspiration for future research and development for amino acid metal coordinated nanomaterials.

关键词: Amino acids, Metal, Coordination chemistry, Cancer therapy, Antibacterial applications, Imaging

Shaobo Wang, Yunchao Zhao, Zeyu Zhang, Yalong Zhang, Linlin Li. Recent advances in amino acid-metal coordinated nanomaterials for biomedical applications[J]. Chinese Journal of Chemical Engineering, 2021, 38(10): 30-42.

Shaobo Wang, Yunchao Zhao, Zeyu Zhang, Yalong Zhang, Linlin Li. Recent advances in amino acid-metal coordinated nanomaterials for biomedical applications[J]. 中国化学工程学报, 2021, 38(10): 30-42.

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