The facile method developed for preparing polyvinylidene fluoride plasma separation membrane via macromolecular interaction

doi:10.1016/j.cjche.2022.07.021

Chinese Journal of Chemical Engineering ›› 2022, Vol. 49 ›› Issue (9): 140-149.DOI: 10.1016/j.cjche.2022.07.021

• Special Column: Membranes for Life Science • Previous Articles Next Articles

The facile method developed for preparing polyvinylidene fluoride plasma separation membrane via macromolecular interaction

Juanjuan Liu^1,2, Xiaolong Lu^2,4, Guiming Shu¹, Ke Li³, Shuyun Zheng², Xiao Kong², Tao Li¹, Jun Yang⁵

1. Tianjin Key Laboratory of Extracorporeal Life Support for Critical Diseases, Tianjin Artificial Cell Engineering Technology Research Center, Institute of Hepatobiliary Disease, The Third Central Hospital Affiliated to Nankai University, Tianjin Third Central Hospital, Tianjin 300170, China;
2. State Key Laboratory of Separation Membrane and Membrane Processes, School of Material Science and Engineering, Institute of Biological and Chemical Engineering, Tiangong University, Tianjin 300387, China;
3. Clinical Laboratory, Tianjin Children's Hospital, Tianjin 300074, China;
4. State Key Laboratory of Membrane Materials and Membrane Applications, Tianjin Motimo Membrane Tech. Co., Ltd, Tianjin 300457, China;
5. The Key Laboratory of Bioactive Materials, College of Life Science, Nankai University, Tianjin 300000, China

Received:2022-02-10 Revised:2022-07-21 Online:2022-10-19
Contact: Xiaolong Lu,E-mail:13920286131@163.com;Tao Li,E-mail:13802091974@163.com
Supported by:
The authors gratefully acknowledge the National Natural Science Foundation of China (21776216), Tianjin Key Laboratory Project (16PTSYJC00210), Program for Innovative Research Team in University of Tianjin (TD13-5044), Science and technology support project of Tianjin (20YFZCSY00310, 21ZXGWSY00040), State Key Laboratory of Separation Membranes and Membrane Processes (Tiangong University), Youth Science Foundation of Tianjin (21JCQNJC00100), Tianjin Health Science and Technology Project (TJWJ2021MS014).

The facile method developed for preparing polyvinylidene fluoride plasma separation membrane via macromolecular interaction

Juanjuan Liu^1,2, Xiaolong Lu^2,4, Guiming Shu¹, Ke Li³, Shuyun Zheng², Xiao Kong², Tao Li¹, Jun Yang⁵

1. Tianjin Key Laboratory of Extracorporeal Life Support for Critical Diseases, Tianjin Artificial Cell Engineering Technology Research Center, Institute of Hepatobiliary Disease, The Third Central Hospital Affiliated to Nankai University, Tianjin Third Central Hospital, Tianjin 300170, China;
2. State Key Laboratory of Separation Membrane and Membrane Processes, School of Material Science and Engineering, Institute of Biological and Chemical Engineering, Tiangong University, Tianjin 300387, China;
3. Clinical Laboratory, Tianjin Children's Hospital, Tianjin 300074, China;
4. State Key Laboratory of Membrane Materials and Membrane Applications, Tianjin Motimo Membrane Tech. Co., Ltd, Tianjin 300457, China;
5. The Key Laboratory of Bioactive Materials, College of Life Science, Nankai University, Tianjin 300000, China

通讯作者: Xiaolong Lu,E-mail:13920286131@163.com;Tao Li,E-mail:13802091974@163.com
基金资助:
The authors gratefully acknowledge the National Natural Science Foundation of China (21776216), Tianjin Key Laboratory Project (16PTSYJC00210), Program for Innovative Research Team in University of Tianjin (TD13-5044), Science and technology support project of Tianjin (20YFZCSY00310, 21ZXGWSY00040), State Key Laboratory of Separation Membranes and Membrane Processes (Tiangong University), Youth Science Foundation of Tianjin (21JCQNJC00100), Tianjin Health Science and Technology Project (TJWJ2021MS014).

Abstract

Abstract: The design of membrane pore is critical for membrane preparation. Polyvinylidene fluoride (PVDF) membrane exhibits outstanding properties in the water-treatment field. However, it is a huge challenge to prepare PVDF macro-pore plasma separation membrane by non-solvent induced phase separation (NIPS). Herein, a facile strategy is proposed to prepare PVDF macro-pore plasma separation membrane via macromolecular interaction. ATR-FTIR and ¹H NMR showed that the intermolecular interaction existed between polyethylene oxide (PEO) and polyvinylpyrrolidone (PVP). It could significantly affect the PVDF macro-pore membrane structure. The maximum pore of the PVDF membrane could be effectively adjusted from small-pore/medium-pore to macro-pore by changing the molecular weight of PEO. The PVDF macro-pore membrane was obtained successfully when PEO-200 k existed with PVP. It exhibited higher plasma separation properties than the currently used plasma separation membrane. Moreover, it had excellent hemocompatibility due to the similar plasma effect, hemolysis, prothrombin time, blood effect and complement C_3a effect with the current utilized plasma separation membrane, implying its great potential application. The proposed facile strategy in this work provides a new method to prepare PVDF macro-pore plasma separation membrane by NIPS.

Key words: Membranes, Macro-pore plasma separation membrane, Hemocompatibility, Purification, Biomedical engineering

摘要： The design of membrane pore is critical for membrane preparation. Polyvinylidene fluoride (PVDF) membrane exhibits outstanding properties in the water-treatment field. However, it is a huge challenge to prepare PVDF macro-pore plasma separation membrane by non-solvent induced phase separation (NIPS). Herein, a facile strategy is proposed to prepare PVDF macro-pore plasma separation membrane via macromolecular interaction. ATR-FTIR and ¹H NMR showed that the intermolecular interaction existed between polyethylene oxide (PEO) and polyvinylpyrrolidone (PVP). It could significantly affect the PVDF macro-pore membrane structure. The maximum pore of the PVDF membrane could be effectively adjusted from small-pore/medium-pore to macro-pore by changing the molecular weight of PEO. The PVDF macro-pore membrane was obtained successfully when PEO-200 k existed with PVP. It exhibited higher plasma separation properties than the currently used plasma separation membrane. Moreover, it had excellent hemocompatibility due to the similar plasma effect, hemolysis, prothrombin time, blood effect and complement C_3a effect with the current utilized plasma separation membrane, implying its great potential application. The proposed facile strategy in this work provides a new method to prepare PVDF macro-pore plasma separation membrane by NIPS.

关键词: Membranes, Macro-pore plasma separation membrane, Hemocompatibility, Purification, Biomedical engineering

Juanjuan Liu, Xiaolong Lu, Guiming Shu, Ke Li, Shuyun Zheng, Xiao Kong, Tao Li, Jun Yang. The facile method developed for preparing polyvinylidene fluoride plasma separation membrane via macromolecular interaction[J]. Chinese Journal of Chemical Engineering, 2022, 49(9): 140-149.

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The facile method developed for preparing polyvinylidene fluoride plasma separation membrane via macromolecular interaction

The facile method developed for preparing polyvinylidene fluoride plasma separation membrane via macromolecular interaction

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