Recent progress in the green synthesis of rare-earth doped upconversion nanophosphors for optical bioimaging from cells to animals

doi:10.1016/j.cjche.2018.03.005

Chin.J.Chem.Eng. ›› 2018, Vol. 26 ›› Issue (10): 2206-2218.DOI: 10.1016/j.cjche.2018.03.005

• Review • Previous Articles

Recent progress in the green synthesis of rare-earth doped upconversion nanophosphors for optical bioimaging from cells to animals

Yuan Pu^1,2, Jingning Leng^1,2, Dan Wang^1,2, Jiexin Wang^1,2, Neil R. Foster^2,3, Jianfeng Chen^1,2

1 Research Center of the Ministry of Education for High Gravity Engineering and Technology, Beijing University of Chemical Technology, Beijing 100029, China;
2 State Key Laboratory of Organic-Inorganic Composites, Beijing University of Chemical Technology, Beijing 100029, China;
3 Department of Chemical Engineering, Curtin University, Perth, WA 6845, Australia

Received:2018-01-10 Revised:2018-02-28 Online:2018-11-14 Published:2018-10-28
Contact: Dan Wang,E-mail address:wangdan@mail.buct.edu.cn
Supported by:
Supported by the National Key Research and Development Program of China (2016YFA0201701/2016YFA0201700), the Beijing Natural Science Foundation (2182051), the National Natural Science Foundation of China (21622601), the Fundamental Research Funds for the Central Universities of China (BUCTRC201601), and the "111" project of China (B14004).

Recent progress in the green synthesis of rare-earth doped upconversion nanophosphors for optical bioimaging from cells to animals

Yuan Pu^1,2, Jingning Leng^1,2, Dan Wang^1,2, Jiexin Wang^1,2, Neil R. Foster^2,3, Jianfeng Chen^1,2

1 Research Center of the Ministry of Education for High Gravity Engineering and Technology, Beijing University of Chemical Technology, Beijing 100029, China;
2 State Key Laboratory of Organic-Inorganic Composites, Beijing University of Chemical Technology, Beijing 100029, China;
3 Department of Chemical Engineering, Curtin University, Perth, WA 6845, Australia

通讯作者: Dan Wang,E-mail address:wangdan@mail.buct.edu.cn
基金资助:
Supported by the National Key Research and Development Program of China (2016YFA0201701/2016YFA0201700), the Beijing Natural Science Foundation (2182051), the National Natural Science Foundation of China (21622601), the Fundamental Research Funds for the Central Universities of China (BUCTRC201601), and the "111" project of China (B14004).

Abstract

Abstract: Rare-earth doped upconversion nanophosphors (UCNPs), which convert low energy near-infrared (NIR) photons into high energy photons such as ultraviolet, visible light and NIR light, have found various applications in optical bioimaging. In this review article, we summarize recent advances in the synthesis and applications of UCNPs achieved by us and other groups in the past few years. The approaches for the synthesis of UCNPs are presented, with an emphasis on the role of green chemistry in the advancement of this field, followed by a focused overview on their latest applications in optical bioimaging from subcellular structures through cells to living animals. Challenges and opportunities for the use of UCNPs in biomedical diagnosis and therapy are discussed.

Key words: Green synthesis, Upconversion luminescence, Nanomaterials, Biomedical engineering, Imaging

摘要： Rare-earth doped upconversion nanophosphors (UCNPs), which convert low energy near-infrared (NIR) photons into high energy photons such as ultraviolet, visible light and NIR light, have found various applications in optical bioimaging. In this review article, we summarize recent advances in the synthesis and applications of UCNPs achieved by us and other groups in the past few years. The approaches for the synthesis of UCNPs are presented, with an emphasis on the role of green chemistry in the advancement of this field, followed by a focused overview on their latest applications in optical bioimaging from subcellular structures through cells to living animals. Challenges and opportunities for the use of UCNPs in biomedical diagnosis and therapy are discussed.

关键词: Green synthesis, Upconversion luminescence, Nanomaterials, Biomedical engineering, Imaging

Yuan Pu, Jingning Leng, Dan Wang, Jiexin Wang, Neil R. Foster, Jianfeng Chen. Recent progress in the green synthesis of rare-earth doped upconversion nanophosphors for optical bioimaging from cells to animals[J]. Chin.J.Chem.Eng., 2018, 26(10): 2206-2218.

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Recent progress in the green synthesis of rare-earth doped upconversion nanophosphors for optical bioimaging from cells to animals

Recent progress in the green synthesis of rare-earth doped upconversion nanophosphors for optical bioimaging from cells to animals

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