Modified DIX model for ion-exchange equilibrium of L-phenylalanine on a strong cation-exchange resin

doi:10.1016/j.cjche.2016.07.009

›› 2016, Vol. 24 ›› Issue (10): 1386-1391.DOI: 10.1016/j.cjche.2016.07.009

• Separation Science and Engineering • Previous Articles Next Articles

Modified DIX model for ion-exchange equilibrium of L-phenylalanine on a strong cation-exchange resin

Jinglan Wu^1,2,3, Pengfei Jiao^1,2,3, Wei Zhuang^1,2,3, Jingwei Zhou^1,2,3, Hanjie Ying^1,2,3,4

1 College of Biotechnology and Pharmaceutical Engineering, Nanjing Tech University, Nanjing 211816, China;
2 National Engineering Technique Research Center for Biotechnology, Nanjing 211816, China;
3 Jiangsu National Synergetic Innovation Center for Advanced Material, Nanjing 210009, China;
4 State Key Laboratory of Materials-Oriented Chemical Engineering, Nanjing 210009, China

Received:2015-11-16 Revised:2016-05-19 Online:2016-11-19 Published:2016-10-28
Supported by:
Supported by the Program for Changjiang Scholars and Innovative Research Team in University (No. IRT1066), National Natural Science Foundation of China (No. 21306086), and Applied Basic Research Programs of Science and Technology Commission Foundation of Jiangsu Province (No. BK20151452).

Modified DIX model for ion-exchange equilibrium of L-phenylalanine on a strong cation-exchange resin

Jinglan Wu^1,2,3, Pengfei Jiao^1,2,3, Wei Zhuang^1,2,3, Jingwei Zhou^1,2,3, Hanjie Ying^1,2,3,4

1 College of Biotechnology and Pharmaceutical Engineering, Nanjing Tech University, Nanjing 211816, China;
2 National Engineering Technique Research Center for Biotechnology, Nanjing 211816, China;
3 Jiangsu National Synergetic Innovation Center for Advanced Material, Nanjing 210009, China;
4 State Key Laboratory of Materials-Oriented Chemical Engineering, Nanjing 210009, China

通讯作者: Hanjie Ying,E-mail address:yinghanjie@njtech.edu.cn.
基金资助:
Supported by the Program for Changjiang Scholars and Innovative Research Team in University (No. IRT1066), National Natural Science Foundation of China (No. 21306086), and Applied Basic Research Programs of Science and Technology Commission Foundation of Jiangsu Province (No. BK20151452).

Abstract

Abstract: L-phenylalanine, one of the nine essential amino acids for the human body, is extensively used as an ingredient in food, pharmaceutical and nutrition industries. A suitable equilibrium model is required for purification of L-phenylalanine based on ion-exchange chromatography. In this work, the equilibrium uptake of L-phenylalanine on a strong acid-cation exchanger SH11 was investigated experimentally and theoretically. A modified Donnan ion-exchange (DIX)model,which takes the activity into account, was established to predict the uptake of L-phenylalanine at various solution pH values. The model parameters including selectivity andmean activity coefficient in the resin phase are presented. The modified DIXmodel is in good agreementwith the experimental data. The optimum operating pH value of 2.0, with the highest L-phenylalanine uptake on the resin, is predicted by themodel. This basic information combined with the general mass transfer model will lay the foundation for the prediction of dynamic behavior of fixed bed separation process.

Key words: Ion-exchange equilibrium, L-phenylalanine, Mathematical modeling, Chromatography, Mean ionic activity coefficient

摘要： L-phenylalanine, one of the nine essential amino acids for the human body, is extensively used as an ingredient in food, pharmaceutical and nutrition industries. A suitable equilibrium model is required for purification of L-phenylalanine based on ion-exchange chromatography. In this work, the equilibrium uptake of L-phenylalanine on a strong acid-cation exchanger SH11 was investigated experimentally and theoretically. A modified Donnan ion-exchange (DIX)model,which takes the activity into account, was established to predict the uptake of L-phenylalanine at various solution pH values. The model parameters including selectivity andmean activity coefficient in the resin phase are presented. The modified DIXmodel is in good agreementwith the experimental data. The optimum operating pH value of 2.0, with the highest L-phenylalanine uptake on the resin, is predicted by themodel. This basic information combined with the general mass transfer model will lay the foundation for the prediction of dynamic behavior of fixed bed separation process.

关键词: Ion-exchange equilibrium, L-phenylalanine, Mathematical modeling, Chromatography, Mean ionic activity coefficient

Jinglan Wu, Pengfei Jiao, Wei Zhuang, Jingwei Zhou, Hanjie Ying. Modified DIX model for ion-exchange equilibrium of L-phenylalanine on a strong cation-exchange resin[J]. , 2016, 24(10): 1386-1391.

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Modified DIX model for ion-exchange equilibrium of L-phenylalanine on a strong cation-exchange resin

Modified DIX model for ion-exchange equilibrium of L-phenylalanine on a strong cation-exchange resin

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