SCI和EI收录∣中国化工学会会刊

Chinese Journal of Chemical Engineering ›› 2019, Vol. 27 ›› Issue (8): 1895-1903.DOI: 10.1016/j.cjche.2018.10.022

• Chemical Engineering Thermodynamics • Previous Articles     Next Articles

Interaction of cetyltrimethylammonium bromide with cefixime trihydrate drug at different temperatures and compositions: Effect of different electrolytes

Marzia Rahman1, Md. Anamul Hoque1, Malik Abdul Rub2,3, Mohammed Abdullah Khan1   

  1. 1 Department of Chemistry, Jahangirnagar University, Savar, Dhaka 1342, Bangladesh;
    2 Chemistry Department, Faculty of Science, King Abdulaziz University, Jeddah 21589, Saudi Arabia;
    3 Center of Excellence for Advanced Materials Research, King Abdulaziz University, Jeddah 21589, Saudi Arabia
  • Received:2018-09-09 Revised:2018-10-18 Online:2019-11-16 Published:2019-08-28
  • Contact: Md. Anamul Hoque

Interaction of cetyltrimethylammonium bromide with cefixime trihydrate drug at different temperatures and compositions: Effect of different electrolytes

Marzia Rahman1, Md. Anamul Hoque1, Malik Abdul Rub2,3, Mohammed Abdullah Khan1   

  1. 1 Department of Chemistry, Jahangirnagar University, Savar, Dhaka 1342, Bangladesh;
    2 Chemistry Department, Faculty of Science, King Abdulaziz University, Jeddah 21589, Saudi Arabia;
    3 Center of Excellence for Advanced Materials Research, King Abdulaziz University, Jeddah 21589, Saudi Arabia
  • 通讯作者: Md. Anamul Hoque

Abstract: Herein, conductivity measurements have been carried out to explore the interaction between cetyltrimethylammonium bromide (CTAB, a cationic surfactant) and antibiotic drug (cefixime trihydrate (CMT)) in water and also in occurrence of inorganic salts (NaCl, Na2SO4 and Na3PO4) over the temperature range of 303.15-323.15 K with an interval of 5 K. In all cases, two critical micelle concentrations (c*) were achieved for the CMT-surfactant system. Addition of CMT drug to CTAB solution decreases the values of c* which indicates the interaction between CMT and CTAB. Both values of c* for CMT-CTAB mixture in the presence of salts are lower in magnitude compared to the aqueous medium which indicates that micellization of the CMT-CTAB mixed system is favorable in salt solution. The values of △Gm0 were obtained to be negative indicating the spontaneity of the micellization process and the extent of spontaneity further increases by means of rising temperature. The obtained outcomes from the △Hm0 and △Sm0 values disclose that the interactions between CMT and CTAB are mostly electrostatic along with hydrophobic in nature. The thermodynamic parameters of transfer and enthalpy-entropy compensation phenomenon were also determined and discussed in detail.

Key words: Cefixime trihydrate, CTAB, Critical micelle concentration, Compensation temperature, Free energy of transfer

摘要: Herein, conductivity measurements have been carried out to explore the interaction between cetyltrimethylammonium bromide (CTAB, a cationic surfactant) and antibiotic drug (cefixime trihydrate (CMT)) in water and also in occurrence of inorganic salts (NaCl, Na2SO4 and Na3PO4) over the temperature range of 303.15-323.15 K with an interval of 5 K. In all cases, two critical micelle concentrations (c*) were achieved for the CMT-surfactant system. Addition of CMT drug to CTAB solution decreases the values of c* which indicates the interaction between CMT and CTAB. Both values of c* for CMT-CTAB mixture in the presence of salts are lower in magnitude compared to the aqueous medium which indicates that micellization of the CMT-CTAB mixed system is favorable in salt solution. The values of △Gm0 were obtained to be negative indicating the spontaneity of the micellization process and the extent of spontaneity further increases by means of rising temperature. The obtained outcomes from the △Hm0 and △Sm0 values disclose that the interactions between CMT and CTAB are mostly electrostatic along with hydrophobic in nature. The thermodynamic parameters of transfer and enthalpy-entropy compensation phenomenon were also determined and discussed in detail.

关键词: Cefixime trihydrate, CTAB, Critical micelle concentration, Compensation temperature, Free energy of transfer