SCI和EI收录∣中国化工学会会刊

›› 2012, Vol. 20 ›› Issue (3): 551-559.

• Festschrift in Honor of Professor Gordon McKay on occasion of his retirement • Previous Articles     Next Articles

Issues in Freeze Drying of Aqueous Solutions

WANG Wei1,3, CHEN Mo1,2, CHEN Guohua3   

  1. 1. College of Life Science, Dalian Nationalities University, Dalian 116600, China;
    2. Department of Chemical Engineering, Dalian University of Technology, Dalian 116024, China;
    3. Department of Chemical and Biomolecular Engineering, the Hong Kong University of Science and Technology, Hong Kong, China
  • Received:2012-03-01 Revised:2012-04-27 Online:2012-08-17 Published:2012-06-28
  • Supported by:
    Supported by the National Natural Science Foundation of China(21076042);Research Grants Council of Hong Kong SAR (RGC 600704)

Issues in Freeze Drying of Aqueous Solutions

王维1,3, 陈墨1,2, 陈国华3   

  1. 1. College of Life Science, Dalian Nationalities University, Dalian 116600, China;
    2. Department of Chemical Engineering, Dalian University of Technology, Dalian 116024, China;
    3. Department of Chemical and Biomolecular Engineering, the Hong Kong University of Science and Technology, Hong Kong, China
  • 通讯作者: CHEN Guohua, E-mail: kechengh@ust.hk
  • 基金资助:
    Supported by the National Natural Science Foundation of China(21076042);Research Grants Council of Hong Kong SAR (RGC 600704)

Abstract: Freeze drying or lyophilization of aqueous solutions is widely used in pharmaceutical industry.The increased importance of the process is gaining a worldwide interest of research.A growing body of literature has demonstrated that the scientific approach can result in improved product quality with minimum trial and error empiricism.Formulation and process development need a systematical understanding of the physical chemistry of freezing and freeze drying,material science and mechanisms of heat and mass transfer.This paper presents an overview on freeze drying of aqueous solutions based on publications in the past few decades.The important issues of the process are analyzed.

Key words: desorption, eutectic formation, excipient, glass transition, sublimation, supercooling

摘要: Freeze drying or lyophilization of aqueous solutions is widely used in pharmaceutical industry.The increased importance of the process is gaining a worldwide interest of research.A growing body of literature has demonstrated that the scientific approach can result in improved product quality with minimum trial and error empiricism.Formulation and process development need a systematical understanding of the physical chemistry of freezing and freeze drying,material science and mechanisms of heat and mass transfer.This paper presents an overview on freeze drying of aqueous solutions based on publications in the past few decades.The important issues of the process are analyzed.

关键词: desorption, eutectic formation, excipient, glass transition, sublimation, supercooling