Photochemical microfluidic synthesis of vitamin D3 by improved light sources with photoluminescent substrates

doi:10.1016/j.cjche.2020.07.016

Chinese Journal of Chemical Engineering ›› 2021, Vol. 29 ›› Issue (1): 204-211.DOI: 10.1016/j.cjche.2020.07.016

• Catalysis, Kinetics and Reaction Engineering • Previous Articles Next Articles

Photochemical microfluidic synthesis of vitamin D₃ by improved light sources with photoluminescent substrates

Wenhao Niu, Yuanzhi Zheng, Ying Li, Le Du, Wei Liu

The State Key Laboratory of Chemical Resource Engineering, Beijing Key Laboratory of Membrane Science and Technology, Beijing University of Chemical Technology, Beijing 100029, China

Received:2020-03-15 Revised:2020-07-02 Online:2021-04-02 Published:2021-01-28
Contact: Le Du, Wei Liu
Supported by:
We gratefully acknowledge the support of the National Natural Science Foundation of China (21978008, 21606008), the State Key Laboratory of Chemical Engineering (SKL-ChE-17A02), the Fundamental Research Funds for the Central Universities (JD2017).

Photochemical microfluidic synthesis of vitamin D₃ by improved light sources with photoluminescent substrates

Wenhao Niu, Yuanzhi Zheng, Ying Li, Le Du, Wei Liu

The State Key Laboratory of Chemical Resource Engineering, Beijing Key Laboratory of Membrane Science and Technology, Beijing University of Chemical Technology, Beijing 100029, China

通讯作者: Le Du, Wei Liu
基金资助:
We gratefully acknowledge the support of the National Natural Science Foundation of China (21978008, 21606008), the State Key Laboratory of Chemical Engineering (SKL-ChE-17A02), the Fundamental Research Funds for the Central Universities (JD2017).

Abstract

Abstract: This study presents a novel technique for the controllable preparation of photoluminescent substrates to enhance the photochemical microfluidic synthesis of vitamin D₃. The dip-coating method to prepare the substrates was experimentally optimized, and the corresponding emission behaviors were systematically investigated. The substrates were successfully used to enhance the ultraviolet B (UVB) emission of a low-power light source (e.g., an 8 W lamp), whose UVB emission intensity was increased by approximately 11 times. By virtue of the novel light source, the productivity of a single set of photochemical microreactor with a 12-meter-long channel (0.6 mm i.d.) was increased to 1.83 kg·a^-1, which was 42% higher than that of a 100 W lamp, and no cooling devices were used. The method is simple and has great potential to replace traditional medium-pressure mercury lamps for UVB-irradiated photochemical reactions.

Key words: Microfluidics, Photochemistry, Composites, UVB emission, Vitamin D₃

摘要： This study presents a novel technique for the controllable preparation of photoluminescent substrates to enhance the photochemical microfluidic synthesis of vitamin D₃. The dip-coating method to prepare the substrates was experimentally optimized, and the corresponding emission behaviors were systematically investigated. The substrates were successfully used to enhance the ultraviolet B (UVB) emission of a low-power light source (e.g., an 8 W lamp), whose UVB emission intensity was increased by approximately 11 times. By virtue of the novel light source, the productivity of a single set of photochemical microreactor with a 12-meter-long channel (0.6 mm i.d.) was increased to 1.83 kg·a^-1, which was 42% higher than that of a 100 W lamp, and no cooling devices were used. The method is simple and has great potential to replace traditional medium-pressure mercury lamps for UVB-irradiated photochemical reactions.

关键词: Microfluidics, Photochemistry, Composites, UVB emission, Vitamin D₃

Wenhao Niu, Yuanzhi Zheng, Ying Li, Le Du, Wei Liu. Photochemical microfluidic synthesis of vitamin D₃ by improved light sources with photoluminescent substrates[J]. Chinese Journal of Chemical Engineering, 2021, 29(1): 204-211.

Wenhao Niu, Yuanzhi Zheng, Ying Li, Le Du, Wei Liu. Photochemical microfluidic synthesis of vitamin D₃ by improved light sources with photoluminescent substrates[J]. 中国化学工程学报, 2021, 29(1): 204-211.

References

[1] Y. Su, V. Hessel, T. Noel, A compact photomicroreactor design for kinetic studies of gas-liquid photocatalytic transformations, AIChE J. 61(2015) 2215-2227.
[2] X.M. Gao, J. Fei, Y.Y. Shang, F. Fu, Desulfurization of liquid hydrocarbon fuels via Cu₂O catalyzed photo-oxidation coupled with liquid-liquid extraction, Chin. J. Chem. Eng. 26(2018) 1508-1512.
[3] W.H. Lei, Q.X. Zhou, G.Y. Jiang, B.W. Zhang, X.S. Wang, Photodynamic inactivation of Escherichia coli by Ru(Ⅱ) complexes, Photochem. Photobiol. Sci. 10(2011) 887-890.
[4] D. Ziegenbalg, B. Wriedt, G. Kreisel, D. Kralisch, Investigation of photon fluxes within microstructured photoreactors revealing great optimization potentials, Chem. Eng. Technol. 39(2016) 123-134.
[5] D. Heggo, S. Ookawara, Multiphase photocatalytic microreactors, Chem. Eng. Sci. 169(2017) 67-77.
[6] J.P. Knowles, L.D. Elliott, K.I. Booker-Milburn, Flow photochemistry:old light through new windows, Beilstein J. Org. Chem. 8(2012) 2025-2052.
[7] W.H. Xu, Y.H. Su, Y. Song, M.J. Shang, L. Zha, Q.H. Lu, Process analysis on preparation of cyclobutanetetracarboxylic dianhydride in a photomicroreactor within gas-liquid Taylor flow, Ind. Eng. Chem. Res. 57(2018) 2476-2485.
[8] A.A. Donaldson, Z. Zisheng, Coupled transport phenomena in corrugated photocatalytic reactors, Chin. J. Chem. Eng. 19(2011) 763-772.
[9] L. Rogers, K.F. Jensen, Continuous manufacturing-the green chemistry promise? Green Chem. 21(2019) 3481-3498.
[10] W. Wang, R. Xie, X.J. Ju, Z. Liu, L.Y. Chu, Progress on control of meso-scale structures for droplet-template syntheses of particle materials, Prog. Chem. 30(2018) 44-50.
[11] Y.C. Lu, S. Zhu, K. Wang, G.S. Luo, Simulation of the mixing process in a straight tube with sudden changed cross-section, Chin. J. Chem. Eng. 24(2016) 711-718.
[12] X. Mao, G.C. Rutledge, T.A. Hatton, Polyvinylferrocene for noncovalent dispersion and redox-controlled precipitation of carbon nanotubes in nonaqueous media, Langmuir 29(2013) 9626-9634.
[13] C.B. Ye, G.W. Chen, Y. Quan, Process characteristics of CO₂ absorption by aqueous monoethanola mine in a microchannel reactor, Chin. J. Chem. Eng. 20(2012) 111-119.
[14] F.J. Wang, J.P. Huang, J.H. Xu, Continuous-flow synthesis of the azo pigment yellow 14 using a three-stream micromixing process, Org. Process. Res. Dev. 23(2019) 2637-2646.
[15] J.W. Kim, A. Fernandez-Nieves, N. Dan, A.S. Utada, M. Marquez, D.A. Weitz, Colloidal assembly route for responsive colloidosomes with tunable permeability, Nano Lett. 7(2007) 2876-2880.
[16] J.S. Sui, J.Y. Yan, D. Liu, K. Wang, G.S. Luo, Continuous synthesis of nanocrystals via flow chemistry technology, Small 16(15) (2019) 1902828.
[17] F. Politano, G. Oksdath-Mansilla, Light on the horizon:current research and future perspectives in flow photochemistry, Org. Process. Res. Dev. 22(2018) 1045-1062.
[18] B. Wang, T. Qiu, B.Z. Chen, Photochemical process modeling and analysis of ozone generation, Chin. J. Chem. Eng. 22(2014) 721-729.
[19] D. Cambie, C. Bottecchia, N.J.W. Straathof, V. Hessel, T. Noel, Applications of continuous-flow photochemistry in organic synthesis, material science, and water treatment, Chem. Rev. 116(2016) 10276-10341.
[20] M. Sender, D. Ziegenbalg, Light sources for photochemical processes-estimation of technological potentials, Chem. Ing. Tech. 89(2017) 1159-1173.
[21] O. Shvydkiv, A. Yavorskyy, K. Nolan, A. Youssef, E. Riguet, N. Hoffmann, M. Oelgemoeller, Photosensitized addition of isopropanol to furanones in a 365 nm UV-LED microchip, Photochem. Photobiol. Sci. 9(2010) 1601-1603.
[22] J.S. Zhang, K. Wang, A.R. Teixeira, K.F. Jensen, G.S. Luo, Design and scaling up of microchemical systems:a review, Annu. Rev. Chem. Biomol. 8(2017) 285-305.
[23] H.S. Santana, J.L. Silva, D.S. Tortola, O.P. Taranto, Transesterification of sunflower oil in microchannels with circular obstructions, Chin. J. Chem. Eng. 26(2018) 852-863.
[24] L.D. Elliott, M. Berry, B. Harji, D. Klauber, J. Leonard, K.I. Booker-Milburn, A smallfootprint, high-capacity flow reactor for UV photochemical synthesis on the kilogram scale, Org. Process. Res. Dev. 20(2016) 1806-1811.
[25] K. Poscharny, D.C. Fabry, S. Heddrich, E. Sugiono, M.A. Liauw, M. Rueping, Machine assisted reaction optimization:a self-optimizing reactor system for continuousflow photochemical reactions, Tetrahedron 74(2018) 3171-3175.
[26] M.P. Ghosh, S. Mandal, S. Mukherjee, Correlations between microstructural and magnetic properties of Gd³⁺-doped spinel ferrite nanoparticles, Eur. Phys. J. Plus. 135(2020) 41.
[27] M. Laube, D. den Engelsen, T. Jansen, G. Fern, P. Harris, T. Ireland, J. Silver, T. Juestel, On the photo-and cathodoluminescence of LaB₃O₆:Gd, Bi, Y₃Al₅O₁₂:Pr, Y₃Al₅O₁₂:Gd, Lu₃Al₅O₁₂:Pr, and Lu₃Al₅O₁₂:Gd, ECS J. Solid State SC. 7(2018) R206-R214.
[28] L. Du, Y.J. Wang, Z.Q. Ren, C. Shen, G.S. Luo, Preparation of Au nanocolloids by in situ dispersion and their applications in surface-enhanced Raman scattering (SERS) films, Ind. Eng. Chem. Res. 55(2016) 6783-6791.
[29] L. Du, Y.J. Wang, J.H. Xu, C. Shen, G.S. Luo, In situ dispersion of non-aqueous Fe₃O₄ nanocolloids by microdroplet coalescence and their use in the preparation of magnetic composite particles, Soft Matter 12(2016) 5180-5187.
[30] M. Escriba-Gelonch, T. Noel, V. Hessel, Microflow high-p,T intensification of vitamin D₃ synthesis using an ultraviolet lamp, Org. Process. Res. Dev. 22(2018) 147-155.
[31] Z.F. Mu, Y.H. Hu, L. Chen, X.J. Wang, R. Chen, T. Wang, Y.R. Fu, J.X. Xu, Synthesis of Bi³⁺ and Gd³⁺ doped ZnB₂O₄ for evaluation as potential materials in luminescent display applications, Displays 35(2014) 147-151.

Photochemical microfluidic synthesis of vitamin D₃ by improved light sources with photoluminescent substrates

Photochemical microfluidic synthesis of vitamin D₃ by improved light sources with photoluminescent substrates

PDF (PC)

Knowledge

Abstract

Cite this article

share this article

References

Related Articles 15

Recommended Articles

Metrics

Comments

[1]	Yingli Li, Zhishuncheng Li, Guangfei Qu, Rui Li, Shuaiyu Liang, Junhong Zhou, Wei Ji, Huiming Tang. Mechanism, behaviour and application of iron nitrate modified carbon nanotube composites for the adsorption of arsenic in aqueous solutions [J]. Chinese Journal of Chemical Engineering, 2023, 60(8): 26-36.
[2]	Masoumeh Sheikh Hosseini Lori, Mohammad Delnavaz, Hoda Khoshvaght. Synthesizing and characterizing the magnetic EDTA/chitosan/CeZnO nanocomposite for simultaneous treating of chromium and phenol in an aqueous solution [J]. Chinese Journal of Chemical Engineering, 2023, 58(6): 76-88.
[3]	Yafei Su, Xuke Zhang, Hui Li, Donglai Peng, Yatao Zhang. In-situ incorporation of halloysite nanotubes with 2D zeolitic imidazolate framework-L based membrane for dye/salt separation [J]. Chinese Journal of Chemical Engineering, 2023, 58(6): 103-111.
[4]	Shanghong Ma, Haitao Zhang, Jianbo Qu, Xiuzhong Zhu, Qingfei Hu, Jianyong Wang, Peng Ye, Futao Sai, Shiwei Chen. Preparation of waterborne polyurethane/β-cyclodextrin composite nanosponge by ion condensation method and its application in removing of dyes from wastewater [J]. Chinese Journal of Chemical Engineering, 2023, 58(6): 124-136.
[5]	Jianhui Zhou, Xin Lai, Jianfeng Hu, Haijie Qi, Shan Liu, Zhengguo Zhang. Design of a graphene oxide@melamine foam/polyaniline@erythritol composite phase change material for thermal energy storage [J]. Chinese Journal of Chemical Engineering, 2023, 58(6): 282-290.
[6]	Chao Yang, Zhelin Su, Yeshuang Wang, Huiling Fan, Meisheng Liang, Zhaohui Chen. Insight into the effect of gel drying temperature on the structure and desulfurization performance of ZnO/SiO₂ adsorbents [J]. Chinese Journal of Chemical Engineering, 2023, 56(4): 233-241.
[7]	Qingyue Han, Suqing Wang, Wenhan Kong, Bing Ji, Haihui Wang. Composite polymer electrolyte reinforced by graphitic carbon nitride nanosheets for room-temperature all-solid-state lithium batteries [J]. Chinese Journal of Chemical Engineering, 2023, 54(2): 257-263.
[8]	Jiacheng Chen, Jincheng Wang, Shuhong Li, Kailing Xiang, Shiqiang Song. Pyridine terminated polyurethane dendrimer/chlorinated butyl rubber nanocomposites with excellent mechanical and damping properties [J]. Chinese Journal of Chemical Engineering, 2023, 53(1): 211-221.
[9]	Qingming Ma, Jianhong Xu. Green microfluidics in microchemical engineering for carbon neutrality [J]. Chinese Journal of Chemical Engineering, 2023, 53(1): 332-345.
[10]	Yingmeng Zhang, Luting Liu, Qingwei Deng, Wanlin Wu, Yongliang Li, Xiangzhong Ren, Peixin Zhang, Lingna Sun. Hybrid CuO-Co₃O₄ nanosphere/RGO sandwiched composites as anode materials for lithium-ion batteries [J]. Chinese Journal of Chemical Engineering, 2022, 47(7): 185-192.
[11]	Jipeng Dong, Fei Wang, Guanghui Chen, Shougui Wang, Cailin Ji, Fei Gao. Fabrication of nickel oxide functionalized zeolite USY composite as a promising adsorbent for CO₂ capture [J]. Chinese Journal of Chemical Engineering, 2022, 46(6): 207-213.
[12]	Iman Farirzadeh, Majid Riahi Samani, Davood Toghraie. Lead removal from aqueous medium using fruit peels and polyaniline composites in aqueous and non-aqueous solvents in the presence of polyethylene glycol [J]. Chinese Journal of Chemical Engineering, 2022, 44(4): 253-259.
[13]	Chen Gu, Wenqiang Weng, Cong Lu, Peng Tan, Yao Jiang, Qiang Zhang, Xiaoqin Liu, Linbing Sun. Decorating MXene with tiny ZIF-8 nanoparticles: An effective approach to construct composites for water pollutant removal [J]. Chinese Journal of Chemical Engineering, 2022, 42(2): 42-48.
[14]	Fang Yang, Wei Zhao, Guiren Wang. Electrokinetic mixing of two fluids with equivalent conductivity [J]. Chinese Journal of Chemical Engineering, 2022, 42(2): 256-260.
[15]	Keya Tang, Jincheng Wang. Chlorinated butyl rubber/two-step modified montmorillonite nanocomposites: Mechanical and damping properties [J]. Chinese Journal of Chemical Engineering, 2022, 42(2): 437-449.