A NEW PROCESS FOR THE EXTRACTION OF PENICILLIN G FROM THE FILTRATE OF FERMENTATION BROTH WITH TBP IN BUTYL ACETATE

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A NEW PROCESS FOR THE EXTRACTION OF PENICILLIN G FROM THE FILTRATE OF FERMENTATION BROTH WITH TBP IN BUTYL ACETATE

YANG Zhifa¹; YU Shuqiu¹; CHEN Jiayong¹; LIU Shouxin²; ZHOU Chongwei²

¹ Institute of Chemical Metallurgy, Academia Sinica, Beijing, 100080

² North China Pharmaceutical Corporation, Shijiazhuang, 050015, Hebei

Received:1991-03-16 Revised:1991-07-16 Online:1992-06-28 Published:1992-06-28
Contact: YANG Zhifa

A NEW PROCESS FOR THE EXTRACTION OF PENICILLIN G FROM THE FILTRATE OF FERMENTATION BROTH WITH TBP IN BUTYL ACETATE

杨智发¹; 于淑秋¹; 陈宋镛¹; 刘守信²; 周重慰²

¹ Institute of Chemical Metallurgy, Academia Sinica, Beijing, 100080

² North China Pharmaceutical Corporation, Shijiazhuang, 050015, Hebei

通讯作者: 杨智发

Abstract

Abstract: The mixture of neutral phosphorus esters and butyl acetate (BA) can be used, as the extractant for the extraction of penicillin G. The extraction equilibrium pH can be increased to pH3—4 due to the stronger extraction capability of the solvent mixture, instead of pH1.8—2.2 with butyl acetate as solvent. The experimental results indicate that the total recovery of penicillin G can reach 96.6% with the new extraction process, which is 5—6% higher than that obtained with the traditional process using BA as solvent at pH1.8—2.2.

Key words: solvent extraction, penicillin G, TBP, butyl acetate

摘要： The mixture of neutral phosphorus esters and butyl acetate (BA) can be used, as the extractant for the extraction of penicillin G. The extraction equilibrium pH can be increased to pH3—4 due to the stronger extraction capability of the solvent mixture, instead of pH1.8—2.2 with butyl acetate as solvent. The experimental results indicate that the total recovery of penicillin G can reach 96.6% with the new extraction process, which is 5—6% higher than that obtained with the traditional process using BA as solvent at pH1.8—2.2.

关键词: solvent extraction;penicillin G;TBP;butyl acetate

YANG Zhifa, YU Shuqiu, CHEN Jiayong, LIU Shouxin, ZHOU Chongwei. A NEW PROCESS FOR THE EXTRACTION OF PENICILLIN G FROM THE FILTRATE OF FERMENTATION BROTH WITH TBP IN BUTYL ACETATE
[J]. , DOI: .

杨智发, 于淑秋, 陈宋镛, 刘守信, 周重慰. A NEW PROCESS FOR THE EXTRACTION OF PENICILLIN G FROM THE FILTRATE OF FERMENTATION BROTH WITH TBP IN BUTYL ACETATE
[J]. , DOI: .

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A NEW PROCESS FOR THE EXTRACTION OF PENICILLIN G FROM THE FILTRATE OF FERMENTATION BROTH WITH TBP IN BUTYL ACETATE

A NEW PROCESS FOR THE EXTRACTION OF PENICILLIN G FROM THE FILTRATE OF FERMENTATION BROTH WITH TBP IN BUTYL ACETATE

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