Polymorphism of D-mannitol: Crystal structure and the crystal growth mechanism

doi:10.1016/j.cjche.2016.09.002

Abstract

Abstract: The polymorphismof D-Mannitol (mannitol) is reviewed in this paper. It was found that the structure of the stable form is consistent in most literatures, but different authors have given different information about the twometastable forms. Therefore the commonly used nomenclature of mannitol was summarized based on the crystal unit cell parameters with the help of X-ray powder diffraction. Moreover, the crystal growth mechanism of mannitol polymorphs was summarized. Considering the lack of kinetic data for themetastable form especially, a reportedmethod was attempted to apply to δ mannitol in an aqueous cooling crystallization process based on the induction time previouslymeasured, and itwas identified that the growth of the δ form follows the two-dimensional (2D) nucleationmediated mechanism. The results also indicate that themethod based on induction timeand supersaturation should have the potential to be expanded to the metastable polymorphs for the growth property study in a bulk system.

Key words: Crystallization, Pharmaceuticals, Polymorphism, D-mannitol, Crystal growth

摘要： The polymorphismof D-Mannitol (mannitol) is reviewed in this paper. It was found that the structure of the stable form is consistent in most literatures, but different authors have given different information about the twometastable forms. Therefore the commonly used nomenclature of mannitol was summarized based on the crystal unit cell parameters with the help of X-ray powder diffraction. Moreover, the crystal growth mechanism of mannitol polymorphs was summarized. Considering the lack of kinetic data for themetastable form especially, a reportedmethod was attempted to apply to δ mannitol in an aqueous cooling crystallization process based on the induction time previouslymeasured, and itwas identified that the growth of the δ form follows the two-dimensional (2D) nucleationmediated mechanism. The results also indicate that themethod based on induction timeand supersaturation should have the potential to be expanded to the metastable polymorphs for the growth property study in a bulk system.

关键词: Crystallization, Pharmaceuticals, Polymorphism, D-mannitol, Crystal growth

Weiyi Su, Na Jia, Hongshi Li, Hongxun Hao, Chunli Li. Polymorphism of D-mannitol: Crystal structure and the crystal growth mechanism[J]. , 2017, 25(3): 358-362.

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