Interaction of cetyltrimethylammonium bromide with cefixime trihydrate drug at different temperatures and compositions: Effect of different electrolytes

doi:10.1016/j.cjche.2018.10.022

Abstract

Abstract: Herein, conductivity measurements have been carried out to explore the interaction between cetyltrimethylammonium bromide (CTAB, a cationic surfactant) and antibiotic drug (cefixime trihydrate (CMT)) in water and also in occurrence of inorganic salts (NaCl, Na₂SO₄ and Na₃PO₄) over the temperature range of 303.15-323.15 K with an interval of 5 K. In all cases, two critical micelle concentrations (c^*) were achieved for the CMT-surfactant system. Addition of CMT drug to CTAB solution decreases the values of c^* which indicates the interaction between CMT and CTAB. Both values of c^* for CMT-CTAB mixture in the presence of salts are lower in magnitude compared to the aqueous medium which indicates that micellization of the CMT-CTAB mixed system is favorable in salt solution. The values of △G_m⁰ were obtained to be negative indicating the spontaneity of the micellization process and the extent of spontaneity further increases by means of rising temperature. The obtained outcomes from the △H_m⁰ and △S_m⁰ values disclose that the interactions between CMT and CTAB are mostly electrostatic along with hydrophobic in nature. The thermodynamic parameters of transfer and enthalpy-entropy compensation phenomenon were also determined and discussed in detail.

Key words: Cefixime trihydrate, CTAB, Critical micelle concentration, Compensation temperature, Free energy of transfer

摘要： Herein, conductivity measurements have been carried out to explore the interaction between cetyltrimethylammonium bromide (CTAB, a cationic surfactant) and antibiotic drug (cefixime trihydrate (CMT)) in water and also in occurrence of inorganic salts (NaCl, Na₂SO₄ and Na₃PO₄) over the temperature range of 303.15-323.15 K with an interval of 5 K. In all cases, two critical micelle concentrations (c^*) were achieved for the CMT-surfactant system. Addition of CMT drug to CTAB solution decreases the values of c^* which indicates the interaction between CMT and CTAB. Both values of c^* for CMT-CTAB mixture in the presence of salts are lower in magnitude compared to the aqueous medium which indicates that micellization of the CMT-CTAB mixed system is favorable in salt solution. The values of △G_m⁰ were obtained to be negative indicating the spontaneity of the micellization process and the extent of spontaneity further increases by means of rising temperature. The obtained outcomes from the △H_m⁰ and △S_m⁰ values disclose that the interactions between CMT and CTAB are mostly electrostatic along with hydrophobic in nature. The thermodynamic parameters of transfer and enthalpy-entropy compensation phenomenon were also determined and discussed in detail.

关键词: Cefixime trihydrate, CTAB, Critical micelle concentration, Compensation temperature, Free energy of transfer

Marzia Rahman, Md. Anamul Hoque, Malik Abdul Rub, Mohammed Abdullah Khan. Interaction of cetyltrimethylammonium bromide with cefixime trihydrate drug at different temperatures and compositions: Effect of different electrolytes[J]. Chinese Journal of Chemical Engineering, 2019, 27(8): 1895-1903.

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