Foaming biocompatible and biodegradable PBAT/PLGA as fallopian tube stent using supercritical carbon dioxide

doi:10.1016/j.cjche.2021.04.028

Chinese Journal of Chemical Engineering ›› 2022, Vol. 47 ›› Issue (7): 245-253.DOI: 10.1016/j.cjche.2021.04.028

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Foaming biocompatible and biodegradable PBAT/PLGA as fallopian tube stent using supercritical carbon dioxide

Yue Wang^1,2, Luyao Huan^1,2, Haiyan Liang¹, Xuejia Ding², Jianguo Mi²

1. Department of Obstetrics and Gynecology, China-Japan Friendship Hospital, No. 2, Yinghuayuandong Road, Beijing 100029, China;
2. State Key Laboratory of Organic-Inorganic Composites, Beijing University of Chemical Technology, No. 15, Beisanhuandong Road, Beijing 100029, China

Received:2021-01-12 Revised:2021-04-19 Online:2022-08-19 Published:2022-07-28
Contact: Haiyan Liang,E-mail:hyliang1976@139.com;Jianguo Mi,E-mail:mijg@mail.buct.edu.cn
Supported by:
This work was supported by Ministry of Education of the People's Republic of China-Joint Foundation of China-Japan Friendship Hospital & Beijing University of Chemical Technology (XK2020-12).

Foaming biocompatible and biodegradable PBAT/PLGA as fallopian tube stent using supercritical carbon dioxide

Yue Wang^1,2, Luyao Huan^1,2, Haiyan Liang¹, Xuejia Ding², Jianguo Mi²

1. Department of Obstetrics and Gynecology, China-Japan Friendship Hospital, No. 2, Yinghuayuandong Road, Beijing 100029, China;
2. State Key Laboratory of Organic-Inorganic Composites, Beijing University of Chemical Technology, No. 15, Beisanhuandong Road, Beijing 100029, China

通讯作者: Haiyan Liang,E-mail:hyliang1976@139.com;Jianguo Mi,E-mail:mijg@mail.buct.edu.cn
基金资助:
This work was supported by Ministry of Education of the People's Republic of China-Joint Foundation of China-Japan Friendship Hospital & Beijing University of Chemical Technology (XK2020-12).

Abstract

Abstract: Tubal pregnancy is a common abnormal pregnancy manifestation, and the ordinary conservative treatment of tubal adhesion usually leads to the rupture of fallopian tube, which increases the risk of a second ectopic pregnancy. To avoid this symptom, it is suitable to implant a stent to separate the adhesion. Here we prepared the PBAT/PLGA foam as the stent material using supercritical CO₂ foaming technology. With uniform macroporous structure and thin-wall feature, the foam possessed low compressive modulus in prevention of the possible second injury to the fallopian tube. The introduction of PLGA 50/50 improved the biodegradable capability of the foam, with a mass loss about 20% after a 12-week hydrolysis. After implanted into the ruptured fallopian tube of the rabbit model, the foam displayed excellent biocompatibility, and provided a good support to prevent tubal adhesion. As such, this work provides the foam material as a promising candidate for fallopian tube stent to remedy the tubal adhesion.

Key words: Bio-foam, Tissue engineering, Low compressive modulus, Rapid hydrolysis

摘要： Tubal pregnancy is a common abnormal pregnancy manifestation, and the ordinary conservative treatment of tubal adhesion usually leads to the rupture of fallopian tube, which increases the risk of a second ectopic pregnancy. To avoid this symptom, it is suitable to implant a stent to separate the adhesion. Here we prepared the PBAT/PLGA foam as the stent material using supercritical CO₂ foaming technology. With uniform macroporous structure and thin-wall feature, the foam possessed low compressive modulus in prevention of the possible second injury to the fallopian tube. The introduction of PLGA 50/50 improved the biodegradable capability of the foam, with a mass loss about 20% after a 12-week hydrolysis. After implanted into the ruptured fallopian tube of the rabbit model, the foam displayed excellent biocompatibility, and provided a good support to prevent tubal adhesion. As such, this work provides the foam material as a promising candidate for fallopian tube stent to remedy the tubal adhesion.

关键词: Bio-foam, Tissue engineering, Low compressive modulus, Rapid hydrolysis

Yue Wang, Luyao Huan, Haiyan Liang, Xuejia Ding, Jianguo Mi. Foaming biocompatible and biodegradable PBAT/PLGA as fallopian tube stent using supercritical carbon dioxide[J]. Chinese Journal of Chemical Engineering, 2022, 47(7): 245-253.

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Foaming biocompatible and biodegradable PBAT/PLGA as fallopian tube stent using supercritical carbon dioxide

Foaming biocompatible and biodegradable PBAT/PLGA as fallopian tube stent using supercritical carbon dioxide

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