SCI和EI收录∣中国化工学会会刊

Chinese Journal of Chemical Engineering ›› 2023, Vol. 58 ›› Issue (6): 170-178.DOI: 10.1016/j.cjche.2022.10.009

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Methanolysis of amides under high-temperature and high-pressure conditions with a continuous tubular reactor

Pengcheng Zou, Kai Wang   

  1. The State Key Lab of Chemical Engineering, Department of Chemical Engineering, Tsinghua University, Beijing 100084, China
  • Received:2022-09-04 Revised:2022-10-18 Online:2023-08-31 Published:2023-06-28
  • Contact: Kai Wang,E-mail:kaiwang@tsinghua.edu.cn
  • Supported by:
    We gratefully acknowledge the financial support from the National Natural Science Foundation of China (21991104) and the Shandong Province Major Science and Technology Innovation Project (2019JZZY020401).

Methanolysis of amides under high-temperature and high-pressure conditions with a continuous tubular reactor

Pengcheng Zou, Kai Wang   

  1. The State Key Lab of Chemical Engineering, Department of Chemical Engineering, Tsinghua University, Beijing 100084, China
  • 通讯作者: Kai Wang,E-mail:kaiwang@tsinghua.edu.cn
  • 基金资助:
    We gratefully acknowledge the financial support from the National Natural Science Foundation of China (21991104) and the Shandong Province Major Science and Technology Innovation Project (2019JZZY020401).

Abstract: The methanolysis of amides, which is widely employed in the synthetic organic chemistry, hardly occurs under mild conditions. To safely and controllably intensify the methanolysis reaction with high-temperature and high-pressure environment, a continuous tubular reaction technology is developed, whose space-time yield is over twice of that of the conventional batch reaction. The methanolysis of acetanilide is selected as the representative reaction, and the influences of temperature, pressure, reactant and catalyst concentration, and residence time on the reaction performances are systematically investigated. Taking the advantages of precise temperature and reaction time control by the tubular reactor, the kinetics of acetanilide methanolysis are determined and compared to the kinetics of acetanilide hydrolysis reaction. The tubular reaction method is also employed to test a variety of other amides to show the effects of substituents, steric hindrance, and alkalinity on the reaction rate of methanolysis.

Key words: Amide methanolysis reaction, Flow chemistry, Continuous reaction, Process intensification

摘要: The methanolysis of amides, which is widely employed in the synthetic organic chemistry, hardly occurs under mild conditions. To safely and controllably intensify the methanolysis reaction with high-temperature and high-pressure environment, a continuous tubular reaction technology is developed, whose space-time yield is over twice of that of the conventional batch reaction. The methanolysis of acetanilide is selected as the representative reaction, and the influences of temperature, pressure, reactant and catalyst concentration, and residence time on the reaction performances are systematically investigated. Taking the advantages of precise temperature and reaction time control by the tubular reactor, the kinetics of acetanilide methanolysis are determined and compared to the kinetics of acetanilide hydrolysis reaction. The tubular reaction method is also employed to test a variety of other amides to show the effects of substituents, steric hindrance, and alkalinity on the reaction rate of methanolysis.

关键词: Amide methanolysis reaction, Flow chemistry, Continuous reaction, Process intensification