Chinese Journal of Chemical Engineering ›› 2019, Vol. 27 ›› Issue (12): 2948-2952.doi: 10.1016/j.cjche.2019.03.015

• Catalysis, kinetics and reaction engineering • Previous Articles     Next Articles

Aminolysis of ethyl acetate in continuous flow and its reaction kinetics

Tao Shen1, Bo Ouyang1,2, Chao Qian1,3, Xinzhi Chen1   

  1. 1 Zhejiang Provincial Key Laboratory of Advanced Chemical Engineering Manufacture Technology, College of Chemical and Biological Engineering, Zhejiang University, Hangzhou 310027, China;
    2 Zhejiang Garden Biochemical High-Tech Co., LTD, Dongyan 322121, China;
    3 Research Institute of Zhejiang University-Quzhou, Quzhou 324000, China
  • Received:2019-01-04 Revised:2019-03-18 Online:2019-12-28 Published:2020-03-17
  • Contact: Chao Qian
  • Supported by:
    The authors are grateful for the financial support from the National Natural Science Foundation of China (21476194) and the National Key Research and Development Program of China (2016YFB0301800).

Abstract: The aminolysis of ethyl acetate was promoted significantly via continuous reaction in a tubular reactor. N-propylacetamide was thus synthesized without presence of solvent and catalyst. The optimum conditions were obtained as follows:the reaction temperature is 218℃, the reaction pressure is 3.5 MPa, the molar ratio (ethyl acetate:N-propylamine) is 1:1, and the residence time is 350 min. Accordingly, the conversion of ethyl acetate is up to 94.8%. Furthermore, the kinetics of the rapid reaction stage (when the conversion of ethyl acetate is 20%-80%) can be expressed as lnk--4629:44 1/T + 2:1366, and the apparent activation energy is Ea=38489 J·mol-1.

Key words: Tubular reactor, Reaction kinetics, Ethyl acetate, Aminolysis