SCI和EI收录∣中国化工学会会刊

中国化学工程学报 ›› 2021, Vol. 38 ›› Issue (10): 221-228.DOI: 10.1016/j.cjche.2021.03.011

• Biotechnology and Bioengineering • 上一篇    下一篇

Hollow mesoporous polyaniline nanoparticles with high drug payload and robust photothermal capability for cancer combination therapy

Yinfeng Zhang1, Fang Fang2, Yongjie Chen3, Min Li2, Li Li1, Wenyue Li4, Jinfeng Zhang2   

  1. 1. International Medical Center, Beijing Friendship Hospital, Capital Medical University, Beijing, 100050, China;
    2. Key Laboratory of Molecular Medicine and Biotherapy, School of Life Sciences, Beijing Institute of Technology, Beijing 100081, China;
    3. College of Pharmacy, Chongqing Medical University, Chongqing 400016, China;
    4. School of Electrical, Computer and Energy Engineering, Arizona State University, Tempe, Arizona, USA
  • 收稿日期:2020-12-23 修回日期:2021-03-19 出版日期:2021-10-28 发布日期:2021-12-02
  • 通讯作者: Wenyue Li, Jinfeng Zhang
  • 基金资助:
    We would like to acknowledge financial support by the National Natural Science Foundation of China (32001010 and 21701018), Beijing Natural Science Foundation (2214078), Beijing Institute of Technology Research Fund Program for Young Scholars, and The Young Elite Scientist Sponsorship Program of Beijing Association for Science and Technology (2021-2023). J. Zhang would also like to thank Biological & Medical Engineering Core Facilities (Beijing Institute of Technology) for providing advanced equipment.

Hollow mesoporous polyaniline nanoparticles with high drug payload and robust photothermal capability for cancer combination therapy

Yinfeng Zhang1, Fang Fang2, Yongjie Chen3, Min Li2, Li Li1, Wenyue Li4, Jinfeng Zhang2   

  1. 1. International Medical Center, Beijing Friendship Hospital, Capital Medical University, Beijing, 100050, China;
    2. Key Laboratory of Molecular Medicine and Biotherapy, School of Life Sciences, Beijing Institute of Technology, Beijing 100081, China;
    3. College of Pharmacy, Chongqing Medical University, Chongqing 400016, China;
    4. School of Electrical, Computer and Energy Engineering, Arizona State University, Tempe, Arizona, USA
  • Received:2020-12-23 Revised:2021-03-19 Online:2021-10-28 Published:2021-12-02
  • Contact: Wenyue Li, Jinfeng Zhang
  • Supported by:
    We would like to acknowledge financial support by the National Natural Science Foundation of China (32001010 and 21701018), Beijing Natural Science Foundation (2214078), Beijing Institute of Technology Research Fund Program for Young Scholars, and The Young Elite Scientist Sponsorship Program of Beijing Association for Science and Technology (2021-2023). J. Zhang would also like to thank Biological & Medical Engineering Core Facilities (Beijing Institute of Technology) for providing advanced equipment.

摘要: In recent years, synergistic chemo-photothermal therapy has revealed promising potential in treatments against various kinds of cancer. However, the development of superb photothermal agents with high drug loading capacity is still highly required. In this work, a hollow mesoporous polyaniline nanoparticle (HPANI NP) has been developed for encapsulating chemotherapeutic drug doxorubicin (DOX) with an remarkable drug loading content as high as 37.5%. Additional PEG modification endowed the drug-loaded HPANI NPs with improved water-dispersibility and bioavailability. Such PEG-HPANI-DOX NPs exhibited strong NIR absorbance and robust photothermal conversion capacity, exhibiting highly efficient synergistic cancer treatment. More interestingly, the responsively released DOX molecules could emit strong red fluorescence, which could be employed to monitor the cellular endocytosis and drug release profile of PEG-HPANI-DOX NPs. Finally, the as-fabricated NPs showed good biocompatibility and low toxicity, serving as a promising nanoagent for highly efficient drug delivery and cancer combination therapy.

关键词: Hollow mesoporous polyaniline nanoparticles, Drug delivery, Nanocarriers, Chemo-photothermal therapy, Cancer combination therapy

Abstract: In recent years, synergistic chemo-photothermal therapy has revealed promising potential in treatments against various kinds of cancer. However, the development of superb photothermal agents with high drug loading capacity is still highly required. In this work, a hollow mesoporous polyaniline nanoparticle (HPANI NP) has been developed for encapsulating chemotherapeutic drug doxorubicin (DOX) with an remarkable drug loading content as high as 37.5%. Additional PEG modification endowed the drug-loaded HPANI NPs with improved water-dispersibility and bioavailability. Such PEG-HPANI-DOX NPs exhibited strong NIR absorbance and robust photothermal conversion capacity, exhibiting highly efficient synergistic cancer treatment. More interestingly, the responsively released DOX molecules could emit strong red fluorescence, which could be employed to monitor the cellular endocytosis and drug release profile of PEG-HPANI-DOX NPs. Finally, the as-fabricated NPs showed good biocompatibility and low toxicity, serving as a promising nanoagent for highly efficient drug delivery and cancer combination therapy.

Key words: Hollow mesoporous polyaniline nanoparticles, Drug delivery, Nanocarriers, Chemo-photothermal therapy, Cancer combination therapy