Halloysite Nanotube Composited Thermo-responsive Hydrogel System for Controlled-release

doi:10.1016/S1004-9541(13)60572-8

Chinese Journal of Chemical Engineering ›› 2013, Vol. 21 ›› Issue (9): 991-998.DOI: 10.1016/S1004-9541(13)60572-8

• 催化、动力学与反应工程 • 上一篇下一篇

Halloysite Nanotube Composited Thermo-responsive Hydrogel System for Controlled-release

林茜, 巨晓洁, 谢锐, 江明月, 魏竭, 褚良银

School of Chemical Engineering, Sichuan University, Chengdu 610065, China

收稿日期:2012-01-27 修回日期:2012-07-11 出版日期:2013-09-28 发布日期:2013-10-01
通讯作者: CHU Liangyin
基金资助:
Supported by the National Natural Science Foundation of China (20906064), the National Basic Research Program of China (2009CB623407), the Program for Changjiang Scholars and Innovative Research Team in University (IRT1163), and the Foundation for the Author of National Excellent Doctoral Dissertation of China (201163)

Halloysite Nanotube Composited Thermo-responsive Hydrogel System for Controlled-release

LIN Xi, JU Xiaojie, XIE Rui, JIANG Mingyue, WEI Jie, CHU Liangyin

School of Chemical Engineering, Sichuan University, Chengdu 610065, China

Received:2012-01-27 Revised:2012-07-11 Online:2013-09-28 Published:2013-10-01
Contact: CHU Liangyin, JU Xiaojie
Supported by:
Supported by the National Natural Science Foundation of China (20906064), the National Basic Research Program of China (2009CB623407), the Program for Changjiang Scholars and Innovative Research Team in University (IRT1163), and the Foundation for the Author of National Excellent Doctoral Dissertation of China (201163)

摘要/Abstract

摘要： Halloysite nanotube-composited thermo-responsive hydrogel system has been successfully developed for controlled drug release by copolymerization of N-isopropylacrylamide (NIPAM) with silane-modified halloysite nanotubes (HNT) through thermally initiated free-radical polymerization. With methylene blue as a model drug, thermo-responsive drug release results demonstrate that the drug release from the nanotubes in the composited hydrogel can be well controlled by manipulating the environmental temperature. When the hydrogel network is swollen at temperature below the lower critical solution temperature (LCST), drug releases steadily from lumens of the embedded nanotubes, whereas the drug release stops when hydrogel shrinks at temperature above the LCST. The release of model drug from the HNT-composited hydrogel matches well with its thermo-responsive volume phase transition, and shows characteristics of well controlled release. The design strategy and release results of the proposed novel HNT-composited thermo-responsive hydrogel system provide valuable guidance for designing responsive nanocomposites for controlled-release of active agents.

关键词: halloysite nanotube, composite hydrogel, controlled release, thermo-responsive carrier, poly(N-isopropylacrylamide)

Abstract: Halloysite nanotube-composited thermo-responsive hydrogel system has been successfully developed for controlled drug release by copolymerization of N-isopropylacrylamide (NIPAM) with silane-modified halloysite nanotubes (HNT) through thermally initiated free-radical polymerization. With methylene blue as a model drug, thermo-responsive drug release results demonstrate that the drug release from the nanotubes in the composited hydrogel can be well controlled by manipulating the environmental temperature. When the hydrogel network is swollen at temperature below the lower critical solution temperature (LCST), drug releases steadily from lumens of the embedded nanotubes, whereas the drug release stops when hydrogel shrinks at temperature above the LCST. The release of model drug from the HNT-composited hydrogel matches well with its thermo-responsive volume phase transition, and shows characteristics of well controlled release. The design strategy and release results of the proposed novel HNT-composited thermo-responsive hydrogel system provide valuable guidance for designing responsive nanocomposites for controlled-release of active agents.

Key words: halloysite nanotube, composite hydrogel, controlled release, thermo-responsive carrier, poly(N-isopropylacrylamide)

林茜, 巨晓洁, 谢锐, 江明月, 魏竭, 褚良银. Halloysite Nanotube Composited Thermo-responsive Hydrogel System for Controlled-release[J]. Chinese Journal of Chemical Engineering, 2013, 21(9): 991-998.

LIN Xi, JU Xiaojie, XIE Rui, JIANG Mingyue, WEI Jie, CHU Liangyin. Halloysite Nanotube Composited Thermo-responsive Hydrogel System for Controlled-release[J]. Chin.J.Chem.Eng., 2013, 21(9): 991-998.

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Halloysite Nanotube Composited Thermo-responsive Hydrogel System for Controlled-release

Halloysite Nanotube Composited Thermo-responsive Hydrogel System for Controlled-release

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