Comprehensive Alcohol-/Ion-Responsive Properties of Poly(N-Isopropylacrylamide-co-Benzo-18-Crown-6-Acrylamide) Copolymers

doi:10.1016/j.cjche.2014.06.021

›› 2014, Vol. 22 ›› Issue (9): 1038-1045.DOI: 10.1016/j.cjche.2014.06.021

Comprehensive Alcohol-/Ion-Responsive Properties of Poly(N-Isopropylacrylamide-co-Benzo-18-Crown-6-Acrylamide) Copolymers

Xiaojie Ju¹, Shuowei Pi¹, Rui Xie¹, Xiaojing Guo², Jieyi Liu¹, Yalan Yu¹, Lu Jiang³, Xiaohua Lu², Qianming Chen³, Liangyin Chu¹

1 School of Chemical Engineering, Sichuan University, Chengdu 610065, China;
2 State Key Laboratory of Materials-Oriented Chemical Engineering, College of Chemistry and Chemical Engineering, Nanjing University of Technology, Nanjing 210009, China;
3 State Key Laboratory of Oral Diseases, Sichuan University, Chengdu 610065, China

收稿日期:2012-11-12 修回日期:2013-04-24 出版日期:2014-09-28 发布日期:2014-11-04
通讯作者: Liangyin Chu
基金资助:
Supported by the National Natural Science Foundation of China (21136006), the Foundation for the Author of National Excellent Doctoral Dissertation of PR China (201163), and the National High Technology Research and Development Program (2012AA021403).

Comprehensive Alcohol-/Ion-Responsive Properties of Poly(N-Isopropylacrylamide-co-Benzo-18-Crown-6-Acrylamide) Copolymers

Xiaojie Ju¹, Shuowei Pi¹, Rui Xie¹, Xiaojing Guo², Jieyi Liu¹, Yalan Yu¹, Lu Jiang³, Xiaohua Lu², Qianming Chen³, Liangyin Chu¹

1 School of Chemical Engineering, Sichuan University, Chengdu 610065, China;
2 State Key Laboratory of Materials-Oriented Chemical Engineering, College of Chemistry and Chemical Engineering, Nanjing University of Technology, Nanjing 210009, China;
3 State Key Laboratory of Oral Diseases, Sichuan University, Chengdu 610065, China

Received:2012-11-12 Revised:2013-04-24 Online:2014-09-28 Published:2014-11-04
Supported by:
Supported by the National Natural Science Foundation of China (21136006), the Foundation for the Author of National Excellent Doctoral Dissertation of PR China (201163), and the National High Technology Research and Development Program (2012AA021403).

摘要/Abstract

摘要： In this paper, we report on the comprehensive alcohol-/ion-responsive properties of a smart copolymer poly(Nisopropylacrylamide-co-benzo-18-crown-6-acrylamide) (P(NIPAM-co-BCAm)). The orthogonal design method is adopted for experimental design. The experimental results show that alcohol can trigger the shrinking and Ba²⁺ can induce the swelling of the P(NIPAM-co-BCAm) copolymer. According to the phase transition temperature (LCST) change results of the copolymer, the influence of variables on the LCST changes weakens in the following order: alcohol concentration N alcohol species N metal ion species N BCAm concentration N ion concentration. The larger the alcohol concentration and the larger the molecular size of alcohols, the lower the LCST value; on the contrary, the more the BCAm content in the copolymer or the larger the BCAm/ion complex stability constant (lgK) or the larger the ion concentration is, the higher the LCST value. For a P(NIPAM-co-BCAm) copolymerwith a fixed BCAmcontent, a binary function of ion concentration and lgK of BCAm/ion is developed to precisely predict the LCST values of the copolymer in different metal ion solutions. The results provide valuable information for fabricating artificial biomimetic G-protein-gated inwardly rectifying potassium (GIRK) channels that are activated by alcohol and inhibited by Ba²⁺.

关键词: Stimuli-responsive material, Phase transition behavior, Alcohol-responsive property, Ion-responsive property

Abstract: In this paper, we report on the comprehensive alcohol-/ion-responsive properties of a smart copolymer poly(Nisopropylacrylamide-co-benzo-18-crown-6-acrylamide) (P(NIPAM-co-BCAm)). The orthogonal design method is adopted for experimental design. The experimental results show that alcohol can trigger the shrinking and Ba²⁺ can induce the swelling of the P(NIPAM-co-BCAm) copolymer. According to the phase transition temperature (LCST) change results of the copolymer, the influence of variables on the LCST changes weakens in the following order: alcohol concentration N alcohol species N metal ion species N BCAm concentration N ion concentration. The larger the alcohol concentration and the larger the molecular size of alcohols, the lower the LCST value; on the contrary, the more the BCAm content in the copolymer or the larger the BCAm/ion complex stability constant (lgK) or the larger the ion concentration is, the higher the LCST value. For a P(NIPAM-co-BCAm) copolymerwith a fixed BCAmcontent, a binary function of ion concentration and lgK of BCAm/ion is developed to precisely predict the LCST values of the copolymer in different metal ion solutions. The results provide valuable information for fabricating artificial biomimetic G-protein-gated inwardly rectifying potassium (GIRK) channels that are activated by alcohol and inhibited by Ba²⁺.

Key words: Stimuli-responsive material, Phase transition behavior, Alcohol-responsive property, Ion-responsive property

Xiaojie Ju, Shuowei Pi, Rui Xie, Xiaojing Guo, Jieyi Liu, Yalan Yu, Lu Jiang, Xiaohua Lu, Qianming Chen, Liangyin Chu. Comprehensive Alcohol-/Ion-Responsive Properties of Poly(N-Isopropylacrylamide-co-Benzo-18-Crown-6-Acrylamide) Copolymers[J]. , 2014, 22(9): 1038-1045.

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Comprehensive Alcohol-/Ion-Responsive Properties of Poly(N-Isopropylacrylamide-co-Benzo-18-Crown-6-Acrylamide) Copolymers

Comprehensive Alcohol-/Ion-Responsive Properties of Poly(N-Isopropylacrylamide-co-Benzo-18-Crown-6-Acrylamide) Copolymers

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