Isolation and structural identification of two bioactive phenazines from Streptomyces griseoluteus P510

doi:10.1016/j.cjche.2015.01.001

Chinese Journal of Chemical Engineering ›› 2015, Vol. 23 ›› Issue (4): 699-703.DOI: 10.1016/j.cjche.2015.01.001

Isolation and structural identification of two bioactive phenazines from Streptomyces griseoluteus P510

Qin Luo, Hongbo Hu, Huasong Peng, Xuehong Zhang, Wei Wang

State Key Laboratory of Microbial Metabolism, School of Life Science and Biotechnology, Shanghai Jiao Tong University, Shanghai 200240, China

收稿日期:2013-03-25 修回日期:2013-12-02 出版日期:2015-04-28 发布日期:2015-05-13
通讯作者: Wei Wang
基金资助:
Supported by the National High Technology Research and Development Program of China (2012AA022107),the National Basic Research Program of China (2012CB722105),the National Natural Science Foundation of China (20706037) and the Ph.D.Programs Foundation of Ministry of Education of China (20090073110052).

Isolation and structural identification of two bioactive phenazines from Streptomyces griseoluteus P510

Qin Luo, Hongbo Hu, Huasong Peng, Xuehong Zhang, Wei Wang

State Key Laboratory of Microbial Metabolism, School of Life Science and Biotechnology, Shanghai Jiao Tong University, Shanghai 200240, China

Received:2013-03-25 Revised:2013-12-02 Online:2015-04-28 Published:2015-05-13
Contact: Wei Wang
Supported by:
Supported by the National High Technology Research and Development Program of China (2012AA022107),the National Basic Research Program of China (2012CB722105),the National Natural Science Foundation of China (20706037) and the Ph.D.Programs Foundation of Ministry of Education of China (20090073110052).

摘要/Abstract

摘要： Phenazine antibiotics phenazine-1-carboxylic acid (PCA) and 1-hydroxyphenazine (1-OH-PHZ) were purified from culture broth and mycelia of Streptomyces griseoluteus P510. Both PCA and 1-OH-PHZ exhibit strong antifun-gal activity against six plant pathogens, especially Fusarium oxysporium, with minimal inhibition concentrations less than 1 and 2 μg·ml^-1 for PCA and 1-OH-PHZ, respectively. The presence of PCA and 1-OH-PHZ indicates that S. griseoluteus P510 can be used as a potential source of pesticides.

关键词: Streptomyces griseoluteus P510, Phenazine antibiotic, Phenazine-1-carboxylic acid, 1-Hydroxyphenazine

Abstract: Phenazine antibiotics phenazine-1-carboxylic acid (PCA) and 1-hydroxyphenazine (1-OH-PHZ) were purified from culture broth and mycelia of Streptomyces griseoluteus P510. Both PCA and 1-OH-PHZ exhibit strong antifun-gal activity against six plant pathogens, especially Fusarium oxysporium, with minimal inhibition concentrations less than 1 and 2 μg·ml^-1 for PCA and 1-OH-PHZ, respectively. The presence of PCA and 1-OH-PHZ indicates that S. griseoluteus P510 can be used as a potential source of pesticides.

Key words: Streptomyces griseoluteus P510, Phenazine antibiotic, Phenazine-1-carboxylic acid, 1-Hydroxyphenazine

Qin Luo, Hongbo Hu, Huasong Peng, Xuehong Zhang, Wei Wang. Isolation and structural identification of two bioactive phenazines from Streptomyces griseoluteus P510[J]. Chinese Journal of Chemical Engineering, 2015, 23(4): 699-703.

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Isolation and structural identification of two bioactive phenazines from Streptomyces griseoluteus P510

Isolation and structural identification of two bioactive phenazines from Streptomyces griseoluteus P510

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