SCI和EI收录∣中国化工学会会刊

›› 2017, Vol. 25 ›› Issue (3): 313-318.DOI: 10.1016/j.cjche.2016.05.046

• Chemical Engineering Thermodynamics • 上一篇    下一篇

Determination of metastable zone and induction time of analgin for cooling crystallization

Ling Zhou1, Zhao Wang1,2, Meijing Zhang1,2, Mingxia Guo1, Shijie Xu1, Qiuxiang Yin1,2   

  1. 1 School of Chemical Engineering and Technology, State Key Laboratory of Chemical Engineering, Tianjin University, Tianjin 300072, China;
    2 Collaborative Innovation Center of Chemical Science and Chemical Engineering, Tianjin 300072, China
  • 收稿日期:2016-04-15 修回日期:2016-05-30 出版日期:2017-03-28 发布日期:2017-04-15
  • 通讯作者: Qiuxiang Yin
  • 基金资助:
    Supported by theNational Natural Science Foundation of China (21206109) and China Ministry of Science and Major National Scientific Instrument Development Project (21527812).

Determination of metastable zone and induction time of analgin for cooling crystallization

Ling Zhou1, ZhaoWang1,2, Meijing Zhang1,2, Mingxia Guo1, Shijie Xu1, Qiuxiang Yin1,2   

  1. 1 School of Chemical Engineering and Technology, State Key Laboratory of Chemical Engineering, Tianjin University, Tianjin 300072, China;
    2 Collaborative Innovation Center of Chemical Science and Chemical Engineering, Tianjin 300072, China
  • Received:2016-04-15 Revised:2016-05-30 Online:2017-03-28 Published:2017-04-15
  • Supported by:
    Supported by theNational Natural Science Foundation of China (21206109) and China Ministry of Science and Major National Scientific Instrument Development Project (21527812).

摘要: The solubility, metastable zone width, and induction time of analgin for unseeded batch cooling crystallization in ethanol-aqueous system were experimentally determined. The solubility data could be well described by the van't Hoff equation model. The metastable zone width at various cooling rates was measured, and some parameters of nucleation kinetic were calculated using the Ny'vlt theory. Furthermore, the induction period of various temperatures and supersaturation ratios was also measured. According to classical nucleation theory, some nucleation parameters and interfacial energy was calculated through the induction time (tind) data. Homogeneous nucleation tended to occurwhen the supersaturation is high, whereas heterogeneous nucleationwasmore likely to occur when the supersaturation is low.

关键词: Analgin, Cooling crystallization, Primary nucleation, Metastable zone, Induction time

Abstract: The solubility, metastable zone width, and induction time of analgin for unseeded batch cooling crystallization in ethanol-aqueous system were experimentally determined. The solubility data could be well described by the van't Hoff equation model. The metastable zone width at various cooling rates was measured, and some parameters of nucleation kinetic were calculated using the Ny'vlt theory. Furthermore, the induction period of various temperatures and supersaturation ratios was also measured. According to classical nucleation theory, some nucleation parameters and interfacial energy was calculated through the induction time (tind) data. Homogeneous nucleation tended to occurwhen the supersaturation is high, whereas heterogeneous nucleationwasmore likely to occur when the supersaturation is low.

Key words: Analgin, Cooling crystallization, Primary nucleation, Metastable zone, Induction time