SCI和EI收录∣中国化工学会会刊

中国化学工程学报 ›› 2020, Vol. 28 ›› Issue (10): 2658-2667.DOI: 10.1016/j.cjche.2020.05.033

• Energy, Resources and Environmental Technology • 上一篇    下一篇

Degradation of methotrexate by UV/peroxymonosulfate: Kinetics, effect of operational parameters and mechanism

Muhammad Imran Kanjal1,2, Majid Muneer2, Amal Abdelhaleem1, Wei Chu1   

  1. 1 Department of Civil and Environmental Engineering, The Hong Kong Polytechnic University, Hung Hom, Kowloon 999077, Hong Kong, China;
    2 Department of Chemistry, Government College University, Faisalabad 38000, Pakistan
  • 收稿日期:2019-09-25 修回日期:2019-11-14 出版日期:2020-10-28 发布日期:2020-12-03
  • 通讯作者: Majid Muneer, Wei Chu

Degradation of methotrexate by UV/peroxymonosulfate: Kinetics, effect of operational parameters and mechanism

Muhammad Imran Kanjal1,2, Majid Muneer2, Amal Abdelhaleem1, Wei Chu1   

  1. 1 Department of Civil and Environmental Engineering, The Hong Kong Polytechnic University, Hung Hom, Kowloon 999077, Hong Kong, China;
    2 Department of Chemistry, Government College University, Faisalabad 38000, Pakistan
  • Received:2019-09-25 Revised:2019-11-14 Online:2020-10-28 Published:2020-12-03
  • Contact: Majid Muneer, Wei Chu

摘要: Methotrexate (MTX) is one of the most consumed anti-cancer drugs in the pharmaceutical market around the world. The widespread occurrence of MTX in aquatic environment through hospital effluent has attracted increasing concern due to its potential to induce water pollution. In the present study, the degradation of MTX in aqueous medium was investigated by UV-activated peroxymonosulfate (PMS). A significant improvement in degradation rate by increasing UV intensity and PMS concentration while the decrease in degradation efficiency with the increase of solution pH and initial concentration of MTX was observed. The proposed UV/PMS process could achieve more than 90% MTX degradation in 30 min with a good mineralization degree (65%). A pseudofirst order kinetic model was employed and successfully predicted the degradation of MTX. The effect of other operational parameters such as the initial concentration of the targeted compound, dosage of oxidant (PMS), solution pH and UV intensity on the degradation rate were investigated. At the last, the main transform intermediates were identified using LC-MS and possible degradation pathways were proposed. The results show that UV/ PMS can be used as an efficient technology to treat pharmaceuticals such as methotrexate containing water and wastewater.

关键词: Peroxymonosulfate, UV radiation, Advanced oxidation process, Methotrexate

Abstract: Methotrexate (MTX) is one of the most consumed anti-cancer drugs in the pharmaceutical market around the world. The widespread occurrence of MTX in aquatic environment through hospital effluent has attracted increasing concern due to its potential to induce water pollution. In the present study, the degradation of MTX in aqueous medium was investigated by UV-activated peroxymonosulfate (PMS). A significant improvement in degradation rate by increasing UV intensity and PMS concentration while the decrease in degradation efficiency with the increase of solution pH and initial concentration of MTX was observed. The proposed UV/PMS process could achieve more than 90% MTX degradation in 30 min with a good mineralization degree (65%). A pseudofirst order kinetic model was employed and successfully predicted the degradation of MTX. The effect of other operational parameters such as the initial concentration of the targeted compound, dosage of oxidant (PMS), solution pH and UV intensity on the degradation rate were investigated. At the last, the main transform intermediates were identified using LC-MS and possible degradation pathways were proposed. The results show that UV/ PMS can be used as an efficient technology to treat pharmaceuticals such as methotrexate containing water and wastewater.

Key words: Peroxymonosulfate, UV radiation, Advanced oxidation process, Methotrexate