Microbial production of L-malate from renewable non-food feedstocks

doi:10.1016/j.cjche.2020.10.017

中国化学工程学报 ›› 2021, Vol. 29 ›› Issue (2): 105-111.DOI: 10.1016/j.cjche.2020.10.017

• Synthetic Biotechnology and Metabolic Engineering • 上一篇下一篇

Microbial production of L-malate from renewable non-food feedstocks

Youming Jiang, Xiaohan Ye, Tianwen Zheng, Weiliang Dong, Fengxue Xin, Jiangfeng Ma, Min Jiang

State Key Laboratory of Materials-Oriented Chemical Engineering, College of Biotechnology and Pharmaceutical Engineering, Nanjing Tech University, Nanjing 211800, China

收稿日期:2020-09-10 修回日期:2020-10-20 出版日期:2021-02-28 发布日期:2021-05-15
通讯作者: Jiangfeng Ma
基金资助:
This work was supported by the National Key R&D Program of China (2018YFA0901500), the National Natural Science Foundation of China (21706124, 21727818), the Key Science and Technology Project of Jiangsu Province (BE2016389), and the Jiangsu Synergetic Innovation Center for Advanced Bio-Manufacture of China.

Microbial production of L-malate from renewable non-food feedstocks

Youming Jiang, Xiaohan Ye, Tianwen Zheng, Weiliang Dong, Fengxue Xin, Jiangfeng Ma, Min Jiang

State Key Laboratory of Materials-Oriented Chemical Engineering, College of Biotechnology and Pharmaceutical Engineering, Nanjing Tech University, Nanjing 211800, China

Received:2020-09-10 Revised:2020-10-20 Online:2021-02-28 Published:2021-05-15
Contact: Jiangfeng Ma
Supported by:
This work was supported by the National Key R&D Program of China (2018YFA0901500), the National Natural Science Foundation of China (21706124, 21727818), the Key Science and Technology Project of Jiangsu Province (BE2016389), and the Jiangsu Synergetic Innovation Center for Advanced Bio-Manufacture of China.

摘要/Abstract

摘要： L-malate is an intermediate of the tricarboxylic acid cycle which is naturally occurred in various microorganisms, and it has been widely applied in polymer, beverage and food, textile, agricultural and pharmaceutical industries. Driven by the pursuit of a sustainable economy, microbial production of L-malate has received much attention in last decades. In this review, we focus on the utilization of wastes and/or byproducts as feedstocks for the microbial production of L-malate. Firstly, we present the recent developments on the natural or engineered metabolic pathways that dedicate to the biosynthesis of L-malate, and also provide a comprehensive discussions on developing high-efficient producers. Then, the recent achievements in microbial production of L-malate from various carbon sources were concluded and discussed. Furthermore, some abundant non-food feedstocks which have been used for microbial production of other chemicals were reviewed, as they may be potential candidate feedstock for L-malate production in future. Finally, we outlined the major challenges and proposed further improvements for the production of L-malate.

关键词: L-malate, Renewable feedstock, Microbial fermentation, Bioeconomy, C4 dicarboxylic acid

Abstract: L-malate is an intermediate of the tricarboxylic acid cycle which is naturally occurred in various microorganisms, and it has been widely applied in polymer, beverage and food, textile, agricultural and pharmaceutical industries. Driven by the pursuit of a sustainable economy, microbial production of L-malate has received much attention in last decades. In this review, we focus on the utilization of wastes and/or byproducts as feedstocks for the microbial production of L-malate. Firstly, we present the recent developments on the natural or engineered metabolic pathways that dedicate to the biosynthesis of L-malate, and also provide a comprehensive discussions on developing high-efficient producers. Then, the recent achievements in microbial production of L-malate from various carbon sources were concluded and discussed. Furthermore, some abundant non-food feedstocks which have been used for microbial production of other chemicals were reviewed, as they may be potential candidate feedstock for L-malate production in future. Finally, we outlined the major challenges and proposed further improvements for the production of L-malate.

Key words: L-malate, Renewable feedstock, Microbial fermentation, Bioeconomy, C4 dicarboxylic acid

Youming Jiang, Xiaohan Ye, Tianwen Zheng, Weiliang Dong, Fengxue Xin, Jiangfeng Ma, Min Jiang. Microbial production of L-malate from renewable non-food feedstocks[J]. 中国化学工程学报, 2021, 29(2): 105-111.

Youming Jiang, Xiaohan Ye, Tianwen Zheng, Weiliang Dong, Fengxue Xin, Jiangfeng Ma, Min Jiang. Microbial production of L-malate from renewable non-food feedstocks[J]. Chinese Journal of Chemical Engineering, 2021, 29(2): 105-111.

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Microbial production of L-malate from renewable non-food feedstocks

Microbial production of L-malate from renewable non-food feedstocks

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