中国化学工程学报 ›› 2021, Vol. 37 ›› Issue (9): 12-29.DOI: 10.1016/j.cjche.2020.11.025
Hang Yao1,2, Yuwei He2,3, Jinrong Ma2, Lang Jiang1, Jingan Li4, Jin Wang1, Nan Huang1
收稿日期:2020-07-06
修回日期:2020-10-15
出版日期:2021-09-28
发布日期:2021-11-02
通讯作者:
Jin Wang
基金资助:Hang Yao1,2, Yuwei He2,3, Jinrong Ma2, Lang Jiang1, Jingan Li4, Jin Wang1, Nan Huang1
Received:2020-07-06
Revised:2020-10-15
Online:2021-09-28
Published:2021-11-02
Contact:
Jin Wang
Supported by:摘要： Treatments of atherogenesis, one of the most common cardiovascular diseases (CVD), are continuously being made thanks to innovation and an increasingly in-depth knowledge of percutaneous transluminal coronary angioplasty (PTCA), the most revolutionary medical procedure used for vascular restoration. Combined with an expanding balloon, vascular stents used at stricture sites enable the long-time restoration of vascular permeability. However, complication after stenting, in-stent restenosis (ISR), hinders the advancement of vascular stents and are associated with high medical costs for patients for decades years. Thus, the development of a high biocompatibility stent with improved safety and efficiency is urgently needed. This review provides an overview of current advances and potential technologies for the modification of stents for better treatment and prevention of ISR. In particular, the mechanisms of in-stent restenosis are investigated and summarized with the aim to comprehensively understanding the pathogenesis of stent complications. Then, according to different therapeutic functions, the current stent modification strategies are reviewed, including polymeric drug eluting stents, biological friendly stents, prohealing stents, and gene stents. Finally, the review provides an outlook of the challenges in the design of stents with optimal properties. Therefore, this review is a valuable and practical guideline for the development of cardiovascular stents.
Hang Yao, Yuwei He, Jinrong Ma, Lang Jiang, Jingan Li, Jin Wang, Nan Huang. Recent advances in cardiovascular stent for treatment of in-stent restenosis: Mechanisms and strategies[J]. 中国化学工程学报, 2021, 37(9): 12-29.
Hang Yao, Yuwei He, Jinrong Ma, Lang Jiang, Jingan Li, Jin Wang, Nan Huang. Recent advances in cardiovascular stent for treatment of in-stent restenosis: Mechanisms and strategies[J]. Chinese Journal of Chemical Engineering, 2021, 37(9): 12-29.
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