SCI和EI收录∣中国化工学会会刊

›› 2008, Vol. 16 ›› Issue (6): 956-960.

• • 上一篇    下一篇

Production of Submicroparticles of β-Sitosterol Using an Aerosol Solvent Extraction System

于文利1, 夏菲1, 金鹤阳1, 林长春1, 赵亚平1, 蒋思源1, 何琳2   

  1. 1. School of Chemistry and Chemical Technology, Shanghai Jiao Tong University, Shanghai 200240, China;
    2. Instrumental Analysis Center, Shanghai Jiao Tong University, Shanghai 200240, China
  • 收稿日期:2008-03-06 修回日期:2008-07-24 出版日期:2008-12-28 发布日期:2008-12-28
  • 通讯作者: ZHAO Yaping,E-mail:ypzhao@sjtu.edu.cn
  • 基金资助:
    Supported by Shanghai Special Foundation on Nanomaterials (0243nm305) and the National High Technology Research and Development Program of China (2007AA10Z350)

Production of Submicroparticles of β-Sitosterol Using an Aerosol Solvent Extraction System

YU Wenli1, XIA Fei1, JIN Heyang1, LIN Changchun1, ZHAO Yaping1, JIANG Siyuan1, HE Lin2   

  1. 1. School of Chemistry and Chemical Technology, Shanghai Jiao Tong University, Shanghai 200240, China;
    2. Instrumental Analysis Center, Shanghai Jiao Tong University, Shanghai 200240, China
  • Received:2008-03-06 Revised:2008-07-24 Online:2008-12-28 Published:2008-12-28
  • Supported by:
    Supported by Shanghai Special Foundation on Nanomaterials (0243nm305) and the National High Technology Research and Development Program of China (2007AA10Z350)

摘要: The submicroparticles of β-sitosterol were produced by using an aerosol solvent extraction system (ASES) and characterized by scanning electronic microscope(SEM),X-ray diffraction(XRD),and Fourier transform infrared(FT-IR) analysis.The effects of operational parameters including pressure,temperature,solution concentration,and ratio of flow rate(CO2/solution,r) on particle size(PS),yield,and morphology were investigated. The results showed that microparticles of β-sitosterol(less than 1000 nm size and larger than 70% yield) could be obtained at 10-15 MPa,35-50℃,15 mg·ml-1,10/1(r);β-sitosterol particles were found to occur as three mophologies:flakes,rods,and spheres by varying ratio of flow rate or solution concentration.In contrast,the crystallinity of β-sitosterol decreased,whereas its molecular structure remained almost unchanged after being ASES-treated. Therefore,ASES was an effective method to produce submicroparticles of β-sitosterol.

关键词: β-sitosterol, submicroparticle, aerosol solvent extraction system, supercritical CO2, micronization

Abstract: The submicroparticles of β-sitosterol were produced by using an aerosol solvent extraction system (ASES) and characterized by scanning electronic microscope(SEM),X-ray diffraction(XRD),and Fourier transform infrared(FT-IR) analysis.The effects of operational parameters including pressure,temperature,solution concentration,and ratio of flow rate(CO2/solution,r) on particle size(PS),yield,and morphology were investigated. The results showed that microparticles of β-sitosterol(less than1000nm size and larger than 70% yield) could be obtained at 10-15 MPa,35-50℃,15 mg·ml-1,10/1(r);β-sitosterol particles were found to occur as three mophologies:flakes,rods,and spheres by varying ratio of flow rate or solution concentration.In contrast,the crystallinity of β-sitosterol decreased,whereas its molecular structure remained almost unchanged after being ASES-treated. Therefore,ASES was an effective method to produce submicroparticles of β-sitosterol.

Key words: β-sitosterol, submicroparticle, aerosol solvent extraction system, supercritical CO2, micronization