Production of Submicroparticles of β-Sitosterol Using an Aerosol Solvent Extraction System

›› 2008, Vol. 16 ›› Issue (6): 956-960.

Production of Submicroparticles of β-Sitosterol Using an Aerosol Solvent Extraction System

于文利¹, 夏菲¹, 金鹤阳¹, 林长春¹, 赵亚平¹, 蒋思源¹, 何琳²

1. School of Chemistry and Chemical Technology, Shanghai Jiao Tong University, Shanghai 200240, China;
2. Instrumental Analysis Center, Shanghai Jiao Tong University, Shanghai 200240, China

收稿日期:2008-03-06 修回日期:2008-07-24 出版日期:2008-12-28 发布日期:2008-12-28
通讯作者: ZHAO Yaping,E-mail:ypzhao@sjtu.edu.cn
基金资助:
Supported by Shanghai Special Foundation on Nanomaterials (0243nm305) and the National High Technology Research and Development Program of China (2007AA10Z350)

Production of Submicroparticles of β-Sitosterol Using an Aerosol Solvent Extraction System

YU Wenli¹, XIA Fei¹, JIN Heyang¹, LIN Changchun¹, ZHAO Yaping¹, JIANG Siyuan¹, HE Lin²

1. School of Chemistry and Chemical Technology, Shanghai Jiao Tong University, Shanghai 200240, China;
2. Instrumental Analysis Center, Shanghai Jiao Tong University, Shanghai 200240, China

Received:2008-03-06 Revised:2008-07-24 Online:2008-12-28 Published:2008-12-28
Supported by:
Supported by Shanghai Special Foundation on Nanomaterials (0243nm305) and the National High Technology Research and Development Program of China (2007AA10Z350)

摘要/Abstract

摘要： The submicroparticles of β-sitosterol were produced by using an aerosol solvent extraction system (ASES) and characterized by scanning electronic microscope(SEM),X-ray diffraction(XRD),and Fourier transform infrared(FT-IR) analysis.The effects of operational parameters including pressure,temperature,solution concentration,and ratio of flow rate(CO₂/solution,r) on particle size(PS),yield,and morphology were investigated. The results showed that microparticles of β-sitosterol(less than 1000 nm size and larger than 70% yield) could be obtained at 10-15 MPa,35-50℃,15 mg·ml^-1,10/1(r);β-sitosterol particles were found to occur as three mophologies:flakes,rods,and spheres by varying ratio of flow rate or solution concentration.In contrast,the crystallinity of β-sitosterol decreased,whereas its molecular structure remained almost unchanged after being ASES-treated. Therefore,ASES was an effective method to produce submicroparticles of β-sitosterol.

关键词: β-sitosterol, submicroparticle, aerosol solvent extraction system, supercritical CO₂, micronization

Abstract: The submicroparticles of β-sitosterol were produced by using an aerosol solvent extraction system (ASES) and characterized by scanning electronic microscope(SEM),X-ray diffraction(XRD),and Fourier transform infrared(FT-IR) analysis.The effects of operational parameters including pressure,temperature,solution concentration,and ratio of flow rate(CO₂/solution,r) on particle size(PS),yield,and morphology were investigated. The results showed that microparticles of β-sitosterol(less than₁₀₀₀nm size and larger than 70% yield) could be obtained at 10-15 MPa,35-50℃,15 mg·ml^-1,10/1(r);β-sitosterol particles were found to occur as three mophologies:flakes,rods,and spheres by varying ratio of flow rate or solution concentration.In contrast,the crystallinity of β-sitosterol decreased,whereas its molecular structure remained almost unchanged after being ASES-treated. Therefore,ASES was an effective method to produce submicroparticles of β-sitosterol.

Key words: β-sitosterol, submicroparticle, aerosol solvent extraction system, supercritical CO₂, micronization

于文利, 夏菲, 金鹤阳, 林长春, 赵亚平, 蒋思源, 何琳. Production of Submicroparticles of β-Sitosterol Using an Aerosol Solvent Extraction System[J]. , 2008, 16(6): 956-960.

YU Wenli, XIA Fei, JIN Heyang, LIN Changchun, ZHAO Yaping, JIANG Siyuan, HE Lin. Production of Submicroparticles of β-Sitosterol Using an Aerosol Solvent Extraction System[J]. , 2008, 16(6): 956-960.

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Production of Submicroparticles of β-Sitosterol Using an Aerosol Solvent Extraction System

Production of Submicroparticles of β-Sitosterol Using an Aerosol Solvent Extraction System

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