Pressured Microwave-assisted Hydrolysis of Crude Glycyrrhizic Acid for Preparation of Glycyrrhetinic Acid

Chinese Journal of Chemical Engineering ›› 2012, Vol. 20 ›› Issue (1): 152-157.

Pressured Microwave-assisted Hydrolysis of Crude Glycyrrhizic Acid for Preparation of Glycyrrhetinic Acid

王仁敏, 林婵, 刘晶靓, 余方, 高建培, 潘学军

Faculty of Environmental Science and Engineering, Kunming University of Science and Technology, Kunming 650093, China

收稿日期:2011-05-20 修回日期:2011-07-05 出版日期:2012-02-28 发布日期:2012-05-03
通讯作者: PAN Xuejun,xjpan@kmust.edu.cn
基金资助:
Supported by the Yunnan Provincial Department of Education Key Foundation (07Z10311)

Pressured Microwave-assisted Hydrolysis of Crude Glycyrrhizic Acid for Preparation of Glycyrrhetinic Acid

WANG Renmin, LIN Chan, LIU Jingliang, YU Fang, GAO Jianpei, PAN Xuejun

Faculty of Environmental Science and Engineering, Kunming University of Science and Technology, Kunming 650093, China

Received:2011-05-20 Revised:2011-07-05 Online:2012-02-28 Published:2012-05-03
Supported by:
Supported by the Yunnan Provincial Department of Education Key Foundation (07Z10311)

摘要/Abstract

摘要： A pressured microwave-assisted hydrolysis(PMAH) technique has been developed for hydrolyzing the crude glycyrrhizic acid(GA) extracted from licorice root to prepare glycyrrhetinic acid(GRA).In order to optimize the efficiency of PMAH,several experimental parameters were investigated,including liquid-solid ratio,hydrolysis time,sulfuric acid concentration and hydrolysis temperature.The optimized hydrolysis conditions were as follows:pressured microwave-assisted hydrolysis of crude GA for 21 min(taking 15 min to reach 150℃,and holding it for 6 min) at 150℃(at a radiation power of 450 W) in 3%-5% sulfuric acid solution with the liquid-solid(ml·g^-1 crude GA) ratio of 25:1.As a result of the considerable saving in time and higher product yields(up to 90%),PMAH was proved more effective than conventional methods.

关键词: glycyrrhetinic acid, glycyrrhizic acid, licorice root, pressured microwave-assisted hydrolysis, high performance liquid chromatography

Abstract: A pressured microwave-assisted hydrolysis(PMAH) technique has been developed for hydrolyzing the crude glycyrrhizic acid(GA) extracted from licorice root to prepare glycyrrhetinic acid(GRA).In order to optimize the efficiency of PMAH,several experimental parameters were investigated,including liquid-solid ratio,hydrolysis time,sulfuric acid concentration and hydrolysis temperature.The optimized hydrolysis conditions were as follows:pressured microwave-assisted hydrolysis of crude GA for 21 min(taking 15 min to reach 150℃,and holding it for 6 min) at 150℃(at a radiation power of 450 W) in 3%-5% sulfuric acid solution with the liquid-solid(ml·g^-1 crude GA) ratio of 25:1.As a result of the considerable saving in time and higher product yields(up to 90%),PMAH was proved more effective than conventional methods.

Key words: glycyrrhetinic acid, glycyrrhizic acid, licorice root, pressured microwave-assisted hydrolysis, high performance liquid chromatography

中图分类号:

TQ464

王仁敏, 林婵, 刘晶靓, 余方, 高建培, 潘学军. Pressured Microwave-assisted Hydrolysis of Crude Glycyrrhizic Acid for Preparation of Glycyrrhetinic Acid[J]. Chinese Journal of Chemical Engineering, 2012, 20(1): 152-157.

WANG Renmin, LIN Chan, LIU Jingliang, YU Fang, GAO Jianpei, PAN Xuejun. Pressured Microwave-assisted Hydrolysis of Crude Glycyrrhizic Acid for Preparation of Glycyrrhetinic Acid[J]. Chin.J.Chem.Eng., 2012, 20(1): 152-157.

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Pressured Microwave-assisted Hydrolysis of Crude Glycyrrhizic Acid for Preparation of Glycyrrhetinic Acid

Pressured Microwave-assisted Hydrolysis of Crude Glycyrrhizic Acid for Preparation of Glycyrrhetinic Acid

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