Modeling of degradation kinetics of Salvianolic acid B at different temperatures and pH values

doi:10.1016/j.cjche.2016.06.005

›› 2017, Vol. 25 ›› Issue (1): 68-73.DOI: 10.1016/j.cjche.2016.06.005

• Catalysis, Kinetics and Reaction Engineering • 上一篇下一篇

Modeling of degradation kinetics of Salvianolic acid B at different temperatures and pH values

Xingchu Gong, Shichao Huang, Jianyang Pan, Haibin Qu

Pharmaceutical Informatics Institute, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, China

收稿日期:2016-03-01 修回日期:2016-06-08 出版日期:2017-01-28 发布日期:2017-02-15
通讯作者: Haibin Qu,E-mail address:quhb@zju.edu.cn
基金资助:
Supported by the National Natural Science Foundation of China (No.81273992) and the Public Service Technology Research and Social Development Project of Science Technology Department of Zhejiang Province of China (2015C33128).

Modeling of degradation kinetics of Salvianolic acid B at different temperatures and pH values

Xingchu Gong, Shichao Huang, Jianyang Pan, Haibin Qu

Pharmaceutical Informatics Institute, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, China

Received:2016-03-01 Revised:2016-06-08 Online:2017-01-28 Published:2017-02-15
Supported by:
Supported by the National Natural Science Foundation of China (No.81273992) and the Public Service Technology Research and Social Development Project of Science Technology Department of Zhejiang Province of China (2015C33128).

摘要/Abstract

摘要： In this work, the effects of degradation time, temperature, and pH value on the degradation of Salvianolic acid B in aqueous solution were determined. Higher pH values, higher extraction temperature, and longer extraction time led to more degradation of Salvianolic acid B. Danshensu concentration increased as Salvianolic acid B degraded. A mechanism model was developed considering the degradation of Salvianolic acid E and lithospermic acid, which were two degradation products of Salvianolic acid B. The reverse reactions of Salvianolic acid B degradation were also considered. Degradation kinetic constants were calibrated. The degradation kinetics of Salvianolic acid B, lithospermic acid, and Danshensu in a Salvia miltiorrhiza extract aqueous solution were predicted using the mechanism model. The predicted concentrations agreed well with the experimental results. This model was developed using degradation data obtained from simple composition systems, but it can be applied in a complex botanical mixture with high prediction accuracy.

关键词: Danshen, Modeling, Hydrolysis, Salvianolic acid B

Abstract: In this work, the effects of degradation time, temperature, and pH value on the degradation of Salvianolic acid B in aqueous solution were determined. Higher pH values, higher extraction temperature, and longer extraction time led to more degradation of Salvianolic acid B. Danshensu concentration increased as Salvianolic acid B degraded. A mechanism model was developed considering the degradation of Salvianolic acid E and lithospermic acid, which were two degradation products of Salvianolic acid B. The reverse reactions of Salvianolic acid B degradation were also considered. Degradation kinetic constants were calibrated. The degradation kinetics of Salvianolic acid B, lithospermic acid, and Danshensu in a Salvia miltiorrhiza extract aqueous solution were predicted using the mechanism model. The predicted concentrations agreed well with the experimental results. This model was developed using degradation data obtained from simple composition systems, but it can be applied in a complex botanical mixture with high prediction accuracy.

Key words: Danshen, Modeling, Hydrolysis, Salvianolic acid B

Xingchu Gong, Shichao Huang, Jianyang Pan, Haibin Qu. Modeling of degradation kinetics of Salvianolic acid B at different temperatures and pH values[J]. , 2017, 25(1): 68-73.

参考文献

[1] Y.A. Zhang, X. Li, Z.Z. Wang, Antioxidant activities of leaf extract of Salvia miltiorrhiza Bunge and related phenolic constituents, Food Chem. Toxicol. 48(2010) 2656-2662.
[2] T.O. Cheng, Cardiovascular effects of Danshen, Int. J. Cardiol. 121(2007) 9-22.
[3] F. Duval, J.E. Moreno-Cuevas, M.T. Gonzalez-Garza, C. Rodriguez-Montalvo, D.E. Cruz-Vega, Protective mechanisms of medicinal plants targeting hepatic stellate cell activation and extracellular matrix deposition in liver fibrosis, Chin. Med. 9(2014) 11.
[4] C.S. Liu, N.H. Chen, J.T. Zhang, Protection of PC12 cells from hydrogen peroxideinduced cytotoxicity by salvianolic acid B, a new compound isolated from Radix Salviae miltiorrhizae, Phytomedicine 14(2007) 492-497.
[5] I.S. Abd-Elazem, H.S. Chen, R.B. Bates, R.C.C. Huang, Isolation of two highly potent and non-toxic inhibitors of human immunodeficiency virus type 1(HIV-1) integrase from Salvia miltiorrhiza, Antivir. Res. 55(2002) 91-106.
[6] J.Y. Pan, X.C. Gong, H.B. Qu, Quantitative H-1 NMR method for hydrolytic kinetic investigation of salvianolic acid B, J. Pharm. Biomed. Anal. 85(2013) 28-32.
[7] X. Zheng, H. Qu, Characterisation of the degradation of salvianolic acid B using an on-line spectroscopic analysis system and multivariate curve resolution, Phytochem. Anal. 23(2012) 103-109.
[8] H.J. Lee, J.Y. Cho, J.H. Moon, Chemical conversions of salvianolic acid B by decoction in aqueous solution, Fitoterapia 83(2012) 1196-1204.
[9] Y.X. Guo, Z.L. Xiu, D.J. Zhang, H. Wang, L.X. Wang, H.B. Xiao, Kinetics and mechanism of degradation of lithospermic acid B in aqueous solution, J. Pharm. Biomed. Anal. 43(2007) 1249-1255.
[10] L.N. Zhou, X. Zhang, W.Z. Xu, X.N. Ma, Z. Jia, Y.M. Zheng, S. You, Studies on the stability of salvianolic acid B as potential drug material, Phytochem. Anal. 22(2011) 378-384.
[11] Y. Wang, J. Zhu, S. Fu, L. Zhu, Y. Zhang, Study on chemical changes of salvianolic acid B and lithospermic acid aqueous under conditions of high temperature and high pressure, China J. Chin. Mater. Med. 36(2011) 434-438.
[12] S.S. Liu, F. Han, H. Xu, K. Liu, Isolation and identification of chemical constituents from thermal decomposition extract of salvianolic acid B, Chin. Tradit. Herb. Drugs 42(2011) 247-250.
[13] X. Zheng, X. Gong, Q. Li, H. Qu, Application of multivariate curve resolution method in the quantitative monitoring transformation of salvianolic acid A using online UV spectroscopy and mass spectroscopy, Ind. Eng. Chem. Res. 51(2012) 3238-3245.
[14] Q. Lin, L. Huang, X.L. Xiao, W. Chen, C.Y. Li, Kinetic study on the degradation of Salvianolic acid B in extract of Salvia miltiorrhiza Bge, Mod. Chin. Med. 10(8) (2008) 29-31.
[15] M. Xu, J. Han, H. Li, L. Fan, A. Liu, D. Guo, Analysis on the stability of total phenolic acids and salvianolic acid B from Salvia miltiorrhiza by HPLC and HPLC-MS (n), Nat. Prod. Commun. 3(2008) 669-676.
[16] L.X. Yu, Pharmaceutical quality by design:Product and process development, understanding, and control, Pharm. Res.-Dordr. 25(2008) 781-791.
[17] L.X. Yu, G. Amidon, M.A. Khan, S.W. Hoag, J. Polli, G.K. Raju, J. Woodcock, Understanding pharmaceutical quality by design, AAPS J. 16(2014) 771-783.
[18] K. Li, D.W. Li, Y.G. Xi, D.B. Yin, Model predictive control with feedforward strategy for gas collectors of coke ovens, Chin. J. Chem. Eng. 22(2014) 769-773.
[19] Y.X. Guo, D.J. Zhang, H. Wang, Z.L. Xiu, L.X. Wang, H.B. Xiao, Hydrolytic kinetics of lithospermic acid B extracted from roots of Salvia miltiorrhiza, J. Pharm. Biomed. Anal. 43(2007) 435-439.
[20] S. Huang, Study on the Effect of Sodium Salt of Danshensu and Protocatechuic Aldehyde on the Degradation of Salvianolic Acid B(Bachelor thesis) Zhejiang University, 2013.

Modeling of degradation kinetics of Salvianolic acid B at different temperatures and pH values

Modeling of degradation kinetics of Salvianolic acid B at different temperatures and pH values

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