SCI和EI收录∣中国化工学会会刊

Chinese Journal of Chemical Engineering ›› 2013, Vol. 21 ›› Issue (9): 937-952.DOI: 10.1016/S1004-9541(13)60560-1

• 综述 •    下一篇

Recent Advances in Separation of Bioactive Natural Products

任其龙, 邢华斌, 鲍宗必, 苏宝根, 杨启炜, 杨亦文, 张治国   

  1. Key Laboratory of Biomass Chemical Engineering of Ministry of Education, Department of Chemical and Biological Engineering, Zhejiang University, Hangzhou 310027, China
  • 收稿日期:2013-03-17 修回日期:2013-05-20 出版日期:2013-09-28 发布日期:2013-10-01
  • 通讯作者: REN Qilong
  • 基金资助:

    Supported by the National Natural Science Foundation of China (20936005, 21076175 and 21076178), the National High Technology Research and Development Program of China (2012AA040211), and the Program for Zhejiang Leading Team of S&T Innovation (2011R50002)

Recent Advances in Separation of Bioactive Natural Products

REN Qilong, XING Huabin, BAO Zongbi, SU Baogen, YANG Qiwei, YANG Yiwen, ZHANG Zhiguo   

  1. Key Laboratory of Biomass Chemical Engineering of Ministry of Education, Department of Chemical and Biological Engineering, Zhejiang University, Hangzhou 310027, China
  • Received:2013-03-17 Revised:2013-05-20 Online:2013-09-28 Published:2013-10-01
  • Contact: REN Qilong
  • Supported by:

    Supported by the National Natural Science Foundation of China (20936005, 21076175 and 21076178), the National High Technology Research and Development Program of China (2012AA040211), and the Program for Zhejiang Leading Team of S&T Innovation (2011R50002)

摘要: Bioactive natural products are a main source of new drugs, functional foods and food additives. The separation of bioactive natural products plays an important role in transformation and use of biomass. The isolation and purification of bioactive principle from a complex matrix is often inherent bottleneck for the utilization of natural products, so a series of extraction and separation techniques have been developed. This review covers recent advances in the separation of bioactive natural products with an emphasis on their solubility and diffusion coefficients, recent extraction techniques and isolation techniques. This overview of recent technological advances, discussion of pertinent problems and prospect of current methodologies in the separation of bioactive natural products may provide a driving force for development of novel separation techniques.

关键词: biomass, chromatography, extraction, isolation, natural products

Abstract: Bioactive natural products are a main source of new drugs, functional foods and food additives. The separation of bioactive natural products plays an important role in transformation and use of biomass. The isolation and purification of bioactive principle from a complex matrix is often inherent bottleneck for the utilization of natural products, so a series of extraction and separation techniques have been developed. This review covers recent advances in the separation of bioactive natural products with an emphasis on their solubility and diffusion coefficients, recent extraction techniques and isolation techniques. This overview of recent technological advances, discussion of pertinent problems and prospect of current methodologies in the separation of bioactive natural products may provide a driving force for development of novel separation techniques.

Key words: biomass, chromatography, extraction, isolation, natural products