SCI和EI收录∣中国化工学会会刊

›› 2017, Vol. 25 ›› Issue (1): 68-73.DOI: 10.1016/j.cjche.2016.06.005

• Catalysis, Kinetics and Reaction Engineering • 上一篇    下一篇

Modeling of degradation kinetics of Salvianolic acid B at different temperatures and pH values

Xingchu Gong, Shichao Huang, Jianyang Pan, Haibin Qu   

  1. Pharmaceutical Informatics Institute, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, China
  • 收稿日期:2016-03-01 修回日期:2016-06-08 出版日期:2017-01-28 发布日期:2017-02-15
  • 通讯作者: Haibin Qu,E-mail address:quhb@zju.edu.cn
  • 基金资助:
    Supported by the National Natural Science Foundation of China (No.81273992) and the Public Service Technology Research and Social Development Project of Science Technology Department of Zhejiang Province of China (2015C33128).

Modeling of degradation kinetics of Salvianolic acid B at different temperatures and pH values

Xingchu Gong, Shichao Huang, Jianyang Pan, Haibin Qu   

  1. Pharmaceutical Informatics Institute, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, China
  • Received:2016-03-01 Revised:2016-06-08 Online:2017-01-28 Published:2017-02-15
  • Supported by:
    Supported by the National Natural Science Foundation of China (No.81273992) and the Public Service Technology Research and Social Development Project of Science Technology Department of Zhejiang Province of China (2015C33128).

摘要: In this work, the effects of degradation time, temperature, and pH value on the degradation of Salvianolic acid B in aqueous solution were determined. Higher pH values, higher extraction temperature, and longer extraction time led to more degradation of Salvianolic acid B. Danshensu concentration increased as Salvianolic acid B degraded. A mechanism model was developed considering the degradation of Salvianolic acid E and lithospermic acid, which were two degradation products of Salvianolic acid B. The reverse reactions of Salvianolic acid B degradation were also considered. Degradation kinetic constants were calibrated. The degradation kinetics of Salvianolic acid B, lithospermic acid, and Danshensu in a Salvia miltiorrhiza extract aqueous solution were predicted using the mechanism model. The predicted concentrations agreed well with the experimental results. This model was developed using degradation data obtained from simple composition systems, but it can be applied in a complex botanical mixture with high prediction accuracy.

关键词: Danshen, Modeling, Hydrolysis, Salvianolic acid B

Abstract: In this work, the effects of degradation time, temperature, and pH value on the degradation of Salvianolic acid B in aqueous solution were determined. Higher pH values, higher extraction temperature, and longer extraction time led to more degradation of Salvianolic acid B. Danshensu concentration increased as Salvianolic acid B degraded. A mechanism model was developed considering the degradation of Salvianolic acid E and lithospermic acid, which were two degradation products of Salvianolic acid B. The reverse reactions of Salvianolic acid B degradation were also considered. Degradation kinetic constants were calibrated. The degradation kinetics of Salvianolic acid B, lithospermic acid, and Danshensu in a Salvia miltiorrhiza extract aqueous solution were predicted using the mechanism model. The predicted concentrations agreed well with the experimental results. This model was developed using degradation data obtained from simple composition systems, but it can be applied in a complex botanical mixture with high prediction accuracy.

Key words: Danshen, Modeling, Hydrolysis, Salvianolic acid B